Coupled benefits of nanotopography and titania surface chemistry in fostering endothelialization and reducing in-stent restenosis in coronary stents

Cherian, Aleena Mary; Joseph, John; Nair, Manitha B.; Nair, Shantikumar V.; Vijayakumar, M.; Menon, Deepthy

doi:10.1016/j.bioadv.2022.213149

Cited by 10 publications

(6 citation statements)

References 56 publications

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“…The 3D scaffolds were produced using the tube-in-the-tube method and had, therefore, a very smooth luminal surface, as shown in Figure 7. This type of surface may prevent stable cell attachment even during magnetic seeding, or-as observed in the case of rotational seeding-result in cell detachment after 7 days [42,43]. Therefore, if this potentially promising material should be used in the future for vascular tissue engineering, it would be necessary to develop an improved production method for 3D scaffolds to provide the cells with a suitable surface nano-/microstructure [44].…”

Section: Discussionmentioning

confidence: 99%

Endothelialization of Whey Protein Isolate-Based Scaffolds for Tissue Regeneration

Genç,

Friedrich,

Alexiou

et al. 2023

Molecules

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Background: Whey protein isolate (WPI) is a by-product from the dairy industry, whose main component is β-lactoglobulin. Upon heating, WPI forms a hydrogel which can both support controlled drug delivery and enhance the proliferation and osteogenic differentiation of bone-forming cells. This study makes a novel contribution by evaluating the ability of WPI hydrogels to support the growth of endothelial cells, which are essential for vascularization, which in turn is a pre-requisite for bone regeneration. Methods: In this study, the proliferation and antioxidant levels in human umbilical vascular endothelial cells (HUVECs) cultured with WPI supplementation were evaluated using real-time cell analysis and flow cytometry. Further, the attachment and growth of HUVECs seeded on WPI-based hydrogels with different concentrations of WPI (15%, 20%, 30%, 40%) were investigated. Results: Supplementation with WPI did not affect the viability or proliferation of HUVECs monitored with real-time cell analysis. At the highest used concentration of WPI (500 µg/mL), a slight induction of ROS production in HUVECs was detected as compared with control samples, but it was not accompanied by alterations in cellular thiol levels. Regarding WPI-based hydrogels, HUVEC adhered and spread on all samples, showing good metabolic activity. Notably, cell number was highest on samples containing 20% and 30% WPI. Conclusions: The demonstration of the good compatibility of WPI hydrogels with endothelial cells in these experiments is an important step towards promoting the vascularization of hydrogels upon implantation in vivo, which is expected to improve implant outcomes in the future.

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Section: Discussionmentioning

confidence: 99%

Endothelialization of Whey Protein Isolate-Based Scaffolds for Tissue Regeneration

Genç,

Friedrich,

Alexiou

et al. 2023

Molecules

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“…FT-IR was used to analyze the adsorption mechanism of the M-T-LIS before and after pickling. The movement of the characteristic peaks [49][50][51][52] of Ti2p 1/2 (0.43 eV), Ti2p 3/2 (0.38 eV), Mn2p 1/2 (0.75 eV), and Mn2p 3/2 (0.55 eV) in Figure 9b,c, the disappearance of the characteristic peak [52] of lithium (Figure 9d), and infrared spectrum (Figure 9e), the vibration peak [53,54] of O-H appears at 3500-3400 cm −1 indicate that Li + in the M-T-LIS is replaced by H + . The chemical environment of Mn and Ti changes from Mn-O-Li, Ti-O-Li, and Mn-Ti-O-Li to Mn-O-H, Ti-O-H, and Mn-Ti-O-H, respectively.…”

Section: Adsorption Mechanismmentioning

confidence: 99%

Manganese-Titanium Mixed Ion Sieves for the Selective Adsorption of Lithium Ions from an Artificial Salt Lake Brine

Ding

Nhung

et al. 2023

Materials

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Lithium recovery is imperative to accommodate the increase in lithium demand. Salt lake brine contains a large amount of lithium and is one of the most important sources of lithium metal. In this study, Li2CO3, MnO2, and TiO2 particles were mixed, and the precursor of a manganese–titanium mixed ion sieve (M-T-LIS) was prepared by a high-temperature solid-phase method. M-T-LISs were obtained by DL-malic acid pickling. The adsorption experiment results noted single-layer chemical adsorption and maximum lithium adsorption of 32.32 mg/g. From the Brunauer–Emmett–Teller and scanning electron microscopy results, the M-T-LIS provided adsorption sites after DL-malic acid pickling. In addition, X-ray photoelectron spectroscopy and Fourier transform infrared results showed the ion exchange mechanism of the M-T-LIS adsorption. From the results of the Li+ desorption experiment and recoverability experiment, DL-malic acid was used to desorb Li+ from the M-T-LIS with a desorption rate of more than 90%. During the fifth cycle, the Li+ adsorption capacity of the M-T-LIS was more than 20 mg/g (25.90 mg/g), and the recovery efficiency was higher than 80% (81.42%). According to the selectivity experiment, the M-T-LIS had good selectivity for Li+ (adsorption capacity of 25.85 mg/g in the artificial salt lake brine), which indicates its good application potential.

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“…Nanostructures mimic the natural extracellular matrix, providing cues that guide cellular behavior and tissue formation. Furthermore, functional groups' immobilization, such as the introduction of peptide sequences or growth factors onto implant surfaces, can modulate cellular responses and facilitate specific tissue integration [119,124].…”

Section: Biomedical and Healthcare Sectormentioning

confidence: 99%

Surface Engineering of Metals: Techniques, Characterizations and Applications

Ramezani

Ripin

Pasang

et al. 2023

Metals

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This paper presents a comprehensive review of recent advancements in surface engineering of metals, encompassing techniques, characterization methods and applications. The study emphasizes the significance of surface engineering in enhancing the performance and functionality of metallic materials in various industries. The paper discusses the different techniques employed in surface engineering, including physical techniques such as thermal spray coatings and chemical techniques such as electroplating. It also explores characterization methods used to assess the microstructural, topographical, and mechanical properties of engineered surfaces. Furthermore, the paper highlights recent advancements in the field, focusing on nanostructured coatings, surface modification for corrosion protection, biomedical applications, and energy-related surface functionalization. It discusses the improved mechanical and tribological properties of nanostructured coatings, as well as the development of corrosion-resistant coatings and bioactive surface treatments for medical implants. The applications of surface engineering in industries such as aerospace, automotive, electronics, and healthcare are presented, showcasing the use of surface engineering techniques to enhance components, provide wear resistance, and improve corrosion protection. The paper concludes by discussing the challenges and future directions in surface engineering, highlighting the need for further research and development to address limitations and exploit emerging trends. The findings of this review contribute to advancing the understanding of surface engineering and its applications in various sectors, paving the way for future innovations and advancements.

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Coupled benefits of nanotopography and titania surface chemistry in fostering endothelialization and reducing in-stent restenosis in coronary stents

Cited by 10 publications

References 56 publications

Endothelialization of Whey Protein Isolate-Based Scaffolds for Tissue Regeneration

Endothelialization of Whey Protein Isolate-Based Scaffolds for Tissue Regeneration

Manganese-Titanium Mixed Ion Sieves for the Selective Adsorption of Lithium Ions from an Artificial Salt Lake Brine

Surface Engineering of Metals: Techniques, Characterizations and Applications

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