2020
DOI: 10.1007/978-3-030-45385-5_7
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Coupled Electro-mechanical Behavior of Microtubules

Abstract: In this contribution, the coupled electro-mechanical behavior of the microtubules has been systematically investigated utilizing a continuum-based finite element framework. A three-dimensional computational model of a microtubule has been developed for predicting the electro-elastic response of the microtubule subjected to external forces. The effects of the magnitude and direction of the applied forces on the mechanics of microtubule have been evaluated. In addition, the effects of variation of microtubule le… Show more

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Cited by 6 publications
(4 citation statements)
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“…Future studies are required to address these limitations to provide further improve the predicted temperature distribution and ablation volume during cardiac ablation. The extension of these models in terms of multiscale coupling at the tissue-cellular scale can be found in [62][63][64][65]. Despite these limitations, we were able to highlight the importance of considering the phase lags in the computational modeling of cardiac ablation for predicting accurate treatment outcomes.…”
Section: Resultsmentioning
confidence: 99%
“…Future studies are required to address these limitations to provide further improve the predicted temperature distribution and ablation volume during cardiac ablation. The extension of these models in terms of multiscale coupling at the tissue-cellular scale can be found in [62][63][64][65]. Despite these limitations, we were able to highlight the importance of considering the phase lags in the computational modeling of cardiac ablation for predicting accurate treatment outcomes.…”
Section: Resultsmentioning
confidence: 99%
“…On the other hand, three different types of spreading patterns exist for the secondary Given that tau is an MT-building protein, its more refined description can be achieved by including corresponding microtubules into consideration. Earlier developed models for the analysis of the microtubules [54][55][56] can prove to be useful for further refinement of the models presented here. Further, it is now known that AD may affect not only the brain but the entire body, including the cardiovascular system 57 .…”
Section: Discussionmentioning
confidence: 98%
“…2b, further analysis has been carried out. By using a coupled model, the electro-mechanical behavior of microtubules has recently been systematically investigated based on a continuum-based finite element framework [21]. The results suggest that the electro-elastic response of microtubules is significantly dependent on both the magnitude and direction of the applied forces, whereas the output potential is linearly proportional to the predicted displacement and the electric potential within the microtubule.…”
Section: Role Of Microtubules and Other Anchoring Organelles Of The Cellmentioning
confidence: 99%