This article establishes a mechanical-electrical-hydraulic vertical torsional coupling vibration mathematical model, and investigates its vibration suppression control strategy with time varying full state constraints for the rolling mill vertical torsional coupling vibration system. Firstly, the mechanical-electrical-hydraulic vertical torsional coupling vibration nonlinear model is developed using dynamic theory, which takes into account nonlinear damping, nonlinear rolling force and the coupling relationship between the vertical vibration system and the torsional vibration system. Then, nonlinear constraint transformation functions and coordinate transformations are implemented to remove the feasibility condition in handling the full state constraints problem, and neural networks are used to approximate unknown nonlinear functions. Furthermore, the vibration suppression control algorithm of the mechanical-electrical-hydraulic vertical torsional coupling system is designed with the specific sequence backstepping method and dynamic surface control technique, which can resolve the problem of nesting in the controller design process. Finally, the effective of the proposed method on vibration suppression is verified by the simulation.