There is no comprehensive understanding of the problems that may impact the performance of the different actors that participate in the design of construction projects. In the absence of clarity about the problems and challenges that may impact the interactions, it is not possible to propose action plans to optimize the performance of the design teams. Therefore, this study proposes to identify the main problems and challenges in the interactions of design teams in building projects. A mixed review method is used to integrate bibliometric reviews, systematic reviews, and social network analysis to build a complete picture of the reviewed topic while highlighting certain key areas to ensure in-depth research. To achieve the objective of this work, the research was divided into three stages: (1) study of interactions in design teams; (2) identification of problems in design team interactions; and (3) study of problems in design team interactions. Through this study, four current major trends of research were identified: (1) Collaboration and BIM; (2) Design teams in the construction industry; (3) Design management; and (4) Collaborative design methodologies and processes. In addition, the most relevant problems or challenges within design team interactions arise in communication, collaboration, coordination, trust, and role identification.