Course of Recovery of Cognitive Impairment in Patients with Schizophrenia: A Randomised Double-blind Study Comparing Sertindole and Haloperidol

Abstract

The study demonstrated two distinct processes of action on cognition between sertindole and haloperidol and the marked beneficial effects of sertindole, particularly in parameters that are regarded as schizophrenia-related cognitive disturbances.

Reversal of Subchronic PCP-Induced Deficits in Attentional Set Shifting in Rats by Sertindole and a 5-HT6 Receptor Antagonist: Comparison Among Antipsychotics

“…Thus, we cannot be certain that repeated dosing of other agents, such as clozapine or M100907, would have no effect. Last, results of the current investigation support and extend findings from a recent clinical trial (Gallhofer et al, 2007). Recently, it has been noted that meaningful cognitive enhancement for individuals with schizophrenia will not likely come from traditional medications (Green, 2007) and even instances where positive effects are reported may be due to practice effects (Goldberg et al, 2007).…”

“…In a small clinical trial, sertindole has shown superiority to haloperidol on executive function performance (Gallhofer et al, 2007). Findings of the current investigation extend these results from clinical trials (Gallhofer et al, 2007) by using a task that is sensitive for the evaluation of executive function in rodents and permits comparisons of several selective pharmacological treatments that are not feasible in clinical trials.…”

“…Risperidone has been shown either to be not effective (Bellack et al, 2004;Remillard et al, 2005;Lee et al, 2007) or slightly effective, as measured by Wisconsin Card Sorting Test (Meltzer and McGurk, 1999;Harvey et al, 2005), and olanzapine produces effects in the same range as risperidone (Meltzer and McGurk, 1999;Bilder et al, 2002;Keefe et al, 2007). In a small clinical trial, sertindole has shown superiority to haloperidol on executive function performance (Gallhofer et al, 2007). Findings of the current investigation extend these results from clinical trials (Gallhofer et al, 2007) by using a task that is sensitive for the evaluation of executive function in rodents and permits comparisons of several selective pharmacological treatments that are not feasible in clinical trials.…”

“…Depending on the type of cognitive domain measured, second-generation antipsychotics have been reported to produce improvement (Mortimer 1997;Meltzer and McGurk, 1999;Keefe et al, 2007), no effect (Hoff et al, 1996;Meltzer and McGurk, 1999), and impairment (Goldberg et al, 1993). The effect of sertindole on cognitive function has not been investigated extensively; however, a small clinical trial indicates a beneficial effect on some cognitive substrates, including executive function, in individuals diagnosed with schizophrenia (Gallhofer et al, 2007). When these data are considered together, second-generation antipsychotics seem superior to typical neuroleptics with regard to cognitive function; however, the selectivity and magnitude of attenuation of cognitive deficits has been variable.…”

Successful treatment of stress-induced cognitive impairment with haloperidol; evaluation also warranted in hematopoietic stem cell transplantation

“…In humans the effect of haloperidol on cognitive impairment has not been studied in relation to cancer therapy, but has been reported in a psychiatric disorder [18][19][20].…”