Course of renal involvement in the short term in children with coronavirus disease 2019

Martin, Sarah E.; Battaglia, Luciana Meni; Beaudoin, Maria Laura; Pérez, Mirleny; Balestracci, Alejandro

doi:10.5546/aap.2021.eng.414

Cited by 2 publications

(3 citation statements)

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“… 7 However, a recent meta-analysis found that the incidence of AKI and kidney replacement therapy was not significantly different in COVID-19 patients compared to other respiratory viruses-related critically ill patients. 5 Although children have a milder disease course, the incidence of AKI has been reported between 0% and 29% in hospitalized children 9 - 14 and as high as 44% in critically ill children. 10 Low albumin and high leukocyte counts were reported as risk factors for AKI, and AKI was associated with longer hospital stay.…”

Section: Discussionmentioning

confidence: 99%

“… 7 There are limited data on the prevalence of proteinuria and hematuria in the pediatric population. 12 , 14 Stewart et al 12 reported a prevalence of proteinuria of 10% and hematuria of 23% in hospitalized pediatric patients. In the current study, the incidence of proteinuria and hematuria was 6% and 15.8% in the whole cohort and 17.4% and 30.4% in hospitalized children, respectively.…”

Section: Discussionmentioning

confidence: 99%

“… 4 Hematuria, proteinuria, and acute kidney injury have been reported in adults with COVID-19, 5 - 8 but data are still limited in the pediatric age group. 9 - 14 The pathophysiology has been thought to be direct viral toxicity to these cells or the effects of systemic inflammation or ischemia on the kidneys. Finally, several cases of glomerulonephritis have been reported that had COVID-19.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Kidney Involvement in Pediatric COVID-19 Cases: A Single-Center Experience

Ağbaş¹,

Akkoç²,

Kizilirmak³

et al. 2022

Turk Arch Pediatrics

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Objective: The kidney is the second most commonly affected organ by severe acute respiratory syndrome coronavirus-2, characterized by hematuria, proteinuria, and acute kidney injury. There are few studies describing renal involvement in pediatric cases. Materials and Methods: This retrospective study evaluated the prevalence of hematuria, proteinuria, and acute kidney injury in severe acute respiratory syndrome coronavirus-2-positive pediatric cases (1-18 years old) who visited emergency department between March and November 2020. Patients with urinary tract infections were excluded. An age-specific upper limit of reference interval was used to define “elevated serum creatinine” (greater than upper limit of reference interval) and acute kidney injury (>1.5 times upper limit of reference interval). Results: A total of 228 patients were evaluated, median age was 12.7 years (interquartile range: 7.5; 16.1), and 51.3% were male. The prevalence of asymptomatic, mild, and moderate-to-severe disease was 12.7% (29/228), 77.2% (176/228), and 10.1% (23/228), respectively. The prevalence of hematuria, proteinuria, and elevated serum creatinine was 15.8% (36/228), 6% (14/228), and 3% (7/228), respectively. Kidney involvement (i.e., at least 1 of these findings) was 23.2% (53/228) and significantly higher in the moderate-to-severe disease (43.5%). None of the patients met the acute kidney injury criterion. In logistic regression analysis, female sex (odds ratio: 1.97, 95 CI%: 1.03; 3.70, P = .040) and fever (odds ratio: 2.28, 95% CI: 1.19; 4.36, P = .012) were independent predictors of kidney involvement. Three patients demonstrated a kidney presentation (macroscopic hematuria) on admission, and another patient was diagnosed with C3 glomerulonephritis during hospitalization. Conclusion: Kidney involvement was found about in 1 quarter of children with coronavirus disease 2019. Awareness and recognition of kidney involvement and follow-up are important in the management.

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