Course of Schizophrenia: What Has Been Learned from Longitudinal Studies?

Bota, Robert G.; Munro, Stuart; Nguyen, Charles; Preda, Adrian

doi:10.1007/978-94-007-0831-0_11

Cited by 4 publications

(4 citation statements)

References 120 publications

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“…As reported above, a number of specific factors in the two areas of impairments that characterize ASD (social communication and repetitive behaviors domains) are likely to hinder positive responses to intervention; however, other factors that are not specific to ASD (e.g., attention span, memory) might also play an important role in predicting outcomes. For example, IQ and language abilities are associated with outcomes across a number of conditions [e.g., schizophrenia ( 114 ), depression ( 115 ), conduct disorder ( 116 )] that are not related to ASD. Indeed, these factors might predict outcomes above and beyond receiving early intervention per se [see Ref.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Outcomes in Autism Early Intervention: Why Donâ€™t We Know More?

et al. 2014

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Response to early intervention programs in autism is variable. However, the factors associated with positive versus poor treatment outcomes remain unknown. Hence the issue of which intervention/s should be chosen for an individual child remains a common dilemma. We argue that lack of knowledge on “what works for whom and why” in autism reflects a number of issues in current approaches to outcomes research, and we provide recommendations to address these limitations. These include: a theory-driven selection of putative predictors; the inclusion of proximal measures that are directly relevant to the learning mechanisms demanded by the specific educational strategies; the consideration of family characteristics. Moreover, all data on associations between predictor and outcome variables should be reported in treatment studies.

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Section: Discussionmentioning

confidence: 99%

Predictors of Outcomes in Autism Early Intervention: Why Donâ€™t We Know More?

et al. 2014

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“…Alterations in global activity can shape the processing of stimulus-induced activity and may provide the basis for the reported changes in cognitive, affective and social functions ( Northoff and Duncan 2016 ). Ultimately, these alterations may underlie the unstable symptoms and symptom severity characteristic of the disorder ( Bota et al. 2011 ; Habtewold et al.…”

Section: Introductionmentioning

confidence: 99%

Phase-Amplitude Markers of Synchrony and Noise: A Resting-State and TMS-EEG Study of Schizophrenia

Freche

Naim-Feil

Hess

et al. 2020

Cerebral Cortex Communications

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The electroencephalogram (EEG) of schizophrenia patients is known to exhibit a reduction of signal-to-noise ratio and of phase locking, as well as a facilitation of excitability, in response to a variety of external stimuli. Here we demonstrate these effects in transcranial magnetic stimulation (TMS)-evoked potentials and in the resting-state EEG. To ensure veracity we used three weekly sessions and analyzed both resting state and TMS-EEG data. For the TMS responses our analysis verifies known results. For the resting state we introduce the methodology of mean-normalized variation to the EEG analysis (quartile-based coefficient of variation), which allows for a comparison of narrow-band EEG amplitude fluctuations to narrow-band Gaussian noise. This reveals that amplitude fluctuations in the delta, alpha and beta bands of healthy controls are different from those in schizophrenia patients, on time scales of tens of seconds. We conclude that the EEG-measured cortical activity patterns of schizophrenia patients are more similar to noise, both in alpha and beta resting state and in TMS responses. Our results suggest that the ability of neuronal populations to form stable, locally and temporally correlated activity is reduced in schizophrenia, a conclusion that is in accord with previous experiments on TMS-EEG and on resting-state EEG.

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“…The classic course of schizophrenia remains chronic with multiple exacerbations and remissions. Most schizophrenia patients' life is characterized by aimlessness, inactivity, frequent hospitalizations, homelessness and poverty [6]. The prognosis is guarded and full recovery is unusual.…”

Section: Introductionmentioning

confidence: 99%

Study of various factors affecting compliance in schizophrenia: A single center experience in India

Shah¹

2019

Arch Psych Psych

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Aim of the study: Schizophrenia is a major psychiatric disorder, imparting a major burden in health care sector. Many treatments are available now a days to treat schizophrenia, although, its burden is not decreasing. The main reason behind this is noncompliance to treatment. This study aims to find out the noncompliance prevalence and to study influence of sociodemographic factors, treatment related variables, illness related variables and various subjective reasoning in patients with schizophrenia.Material and methods: Over the period of 1 year, 80 patients with schizophrenia who gave written informed consent were enrolled in the study and their sociodemographic, treatment related and illness related variables were noted. PANSS(positive and negative syndrome scale for Schizophrenia) was used to indicate the severity of illness. ROMI(Rating of Medication Influences Scale in Schizophrenia) was used to assess subjective reasons. Chi square test was used to find out statistical significance.Results: 37.5% patients were non-compliant in our study. Education, the illness severity, the type of regimen and dosages of medication have a significant influence on treatment compliance. The subjective reason "no perceived benefit" is significantly associated with treatment noncompliance.

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Course of Schizophrenia: What Has Been Learned from Longitudinal Studies?

Cited by 4 publications

References 120 publications

Predictors of Outcomes in Autism Early Intervention: Why Donâ€™t We Know More?

Predictors of Outcomes in Autism Early Intervention: Why Donâ€™t We Know More?

Phase-Amplitude Markers of Synchrony and Noise: A Resting-State and TMS-EEG Study of Schizophrenia

Study of various factors affecting compliance in schizophrenia: A single center experience in India

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