Covalent functionalization of Ti3C2T MXene flakes with Gd-DTPA complex for stable and biocompatible MRI contrast agent

Neubertova, Viktoria; Guselnikova, Olga; Yamauchi, Yusuke; Olshtrem, Anastasiia; Rimpelová, Silvie; Čižmár, E.; Orendáč, M.; Duchoň, Jan; Volfová, Lenka; Lančok, J.; Herynek, Vı́t; Fitl, Přemysl; Ulbrich, Pavel; Jelínek, Luděk; Schneider, Patrik; Košek, Juraj; Postnikov, Pavel; Kolská, Zdeňka; Švorčı́k, Václav; Chertopalov, Sergej; Lyutakov, Olekisy

doi:10.1016/j.cej.2022.136939

Cited by 27 publications

(13 citation statements)

References 59 publications

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“…43 The vibrations from phenyl CQC bonds appear at 853 and 1161 cm À1 , suggesting the successful grafting of 4-benzaldehyde groups onto MXene. 24,54 The band representing Ti-OH, Ti-O, and Ti-C bonds exhibits a shift towards a higher wavenumber, attributed to the change in chemical composition on the surface of nanosheets. Notably, the characteristic N 2 + vibration of 4-benzaldehyde diazonium is centered at 2298 cm À1 (Fig.…”

Section: Characterizationmentioning

confidence: 99%

Covalent chemical functionalization of Ti₃C₂T_x MXene nanosheets with fullerenes C₆₀ and C₇₀ for enhanced nonlinear optical limiting

et al. 2023

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Section: Characterizationmentioning

confidence: 99%

Covalent chemical functionalization of Ti₃C₂T_x MXene nanosheets with fullerenes C₆₀ and C₇₀ for enhanced nonlinear optical limiting

et al. 2023

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“…For example, Lyutakov et al loaded the MR contrast agent (Gd-chelate diethylenetriaminepentaacetic acid) onto the Ti 3 C 2 T flakes via the covalent interaction with the surface groups of MXene and demonstrated that the obtained imaging nanosystem (MXene-Gd) not only reserved the good biocompatibility of naked MXene but also exhibited enhanced blood stability (Figure 10A). [125] Thus, MXene-Gd is very promising in the application of tumor theranostics when combined with the PTT effect of MXene.…”

Section: Mxenes Loaded With Imaging Componentsmentioning

confidence: 99%

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confidence: 99%

MXene‐Based Functional Platforms for Tumor Therapy

et al. 2023

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Recently, 2D transition metal carbide, nitride, and carbonitrides (MXenes) materials stand out in the field of tumor therapy, particularly in the construction of functional platforms for optimal antitumor therapy due to their high specific surface area, tunable performance, strong absorption of near‐infrared light as well as preferable surface plasmon resonance effect. In this review, we summarize the progress of MXene‐mediated antitumor therapy after appropriate modifications or integration procedures. We discuss in detail the enhanced antitumor treatments directly performed by MXenes, the significant improving effect of MXenes on different antitumor therapies, as well as the MXene‐mediated imaging‐guided antitumor strategies. Moreover, the existing challenges and future development directions of MXenes in tumor therapy are presented.This article is protected by copyright. All rights reserved

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“…Paramagnetic cations, such as manganese [ 96 , 97 ] and gadolinium [ 98 , 99 ], and gadolinium chelates such as Gd(DTPA) [ 82 , 100 ] have been used as T 1 contrast agents, and the contrast in T 2 signals has been enhanced by superparamagnetic iron oxide [ 101 , 102 ].…”

Section: Design Of Functional Ldh Nanohybrids For Imagingmentioning

confidence: 99%

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

Choi

2023

Nanomaterials

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Two-dimensional nanomaterials, particularly layered double hydroxides (LDHs), have been widely applied in the biomedical field owing to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. Since the first study analyzing intercalative LDHs in 1999, numerous studies have investigated their biomedical applications, including drug delivery and imaging; recent research has focused on the design and development of multifunctional LDHs. This review summarizes the synthetic strategies and in-vivo and in-vitro therapeutic actions and targeting properties of single-function LDH-based nanohybrids and recently reported (from 2019 to 2023) multifunctional systems developed for drug delivery and/or bio-imaging.

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Covalent functionalization of Ti3C2T MXene flakes with Gd-DTPA complex for stable and biocompatible MRI contrast agent

Cited by 27 publications

References 59 publications

Covalent chemical functionalization of Ti₃C₂T_x MXene nanosheets with fullerenes C₆₀ and C₇₀ for enhanced nonlinear optical limiting

Covalent chemical functionalization of Ti₃C₂T_x MXene nanosheets with fullerenes C₆₀ and C₇₀ for enhanced nonlinear optical limiting

MXene‐Based Functional Platforms for Tumor Therapy

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

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Covalent functionalization of Ti3C2T MXene flakes with Gd-DTPA complex for stable and biocompatible MRI contrast agent

Cited by 27 publications

References 59 publications

Covalent chemical functionalization of Ti3C2Tx MXene nanosheets with fullerenes C60 and C70 for enhanced nonlinear optical limiting

Covalent chemical functionalization of Ti3C2Tx MXene nanosheets with fullerenes C60 and C70 for enhanced nonlinear optical limiting

MXene‐Based Functional Platforms for Tumor Therapy

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

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Product

Resources

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Covalent chemical functionalization of Ti₃C₂T_x MXene nanosheets with fullerenes C₆₀ and C₇₀ for enhanced nonlinear optical limiting

Covalent chemical functionalization of Ti₃C₂T_x MXene nanosheets with fullerenes C₆₀ and C₇₀ for enhanced nonlinear optical limiting