Covalent inhibition of epidermal growth factor receptor using a long-lived iridium(III)-afatinib probe

Nao, Sang-Cuo; Kong, Lingtan; Chan, Daniel Shiu-Hin; Liu, Jianhua; Huang, Le-Sheng; Wu, Lei; Wu, Jia; Wong, Chun-Yuen; Wang, Wanhe; Leung, Chung-Hang

doi:10.1016/j.ijbiomac.2024.129211

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Cited by 3 publications

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“…27 It covalently binds to the kinase domain of EGFR and irreversibly inhibits tyrosine kinase autophosphorylation, resulting in downregulation of EGFR downstream signaling. 28…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Abd El-Lateef,

Bafail,

Alhalees

et al. 2024

RSC Adv.

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“…27 It covalently binds to the kinase domain of EGFR and irreversibly inhibits tyrosine kinase autophosphorylation, resulting in downregulation of EGFR downstream signaling. 28…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Abd El-Lateef,

Bafail,

Alhalees

et al. 2024

RSC Adv.

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Selective detection of mitochondrial Cu2+ in living cells by a near-infrared iridium(III) complex

Du,

Wu,

et al. 2025

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Development of a NIR Iridium(III) Complex-Based Probe for the Selective Detection of Iron(II) Ions

Wang,

Zhang,

Liu

et al. 2024

Biosensors

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As a commonly used metal ion, iron(II) (Fe2+) ions pose a potential threat to ecosystems and human health. Therefore, it is particularly important to develop analytical techniques for the rapid and accurate detection of Fe2+ ions. However, the development of near-infrared (NIR) luminescence probes with good photostability for Fe2+ ions remain challenging. In this work, we report a novel iridium(III) complex-based luminescence probe for the sensitive and rapid detection of Fe2+ ions in a solution based on an Fe2+-mediated reduction reaction. This probe is capable of sensitively detecting Fe2+ ions with a limit of detection (LOD) of 0.26 μM. Furthermore, this probe shows high photostability, and its luminescence remains stable under 365 nm irradiation over a time period of 30 min. To our knowledge, this is first iridium(III) complex-based NIR probe for the detection of Fe2+ ions. We believe that this work provides a new method for the detection of Fe2+ ions and has great potential for future applications in water quality testing and human monitoring.

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Covalent inhibition of epidermal growth factor receptor using a long-lived iridium(III)-afatinib probe

Cited by 3 publications

References 39 publications

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Synthesis, characterization and biological research of novel 2-(quinoline-4-carbonyl)hydrazide-acrylamide hybrids as potential anticancer agents on MCF-7 breast carcinoma cells by targeting EGFR-TK

Selective detection of mitochondrial Cu2+ in living cells by a near-infrared iridium(III) complex

Development of a NIR Iridium(III) Complex-Based Probe for the Selective Detection of Iron(II) Ions

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