“…Chemotherapeutics that are commonly used include doxorubicin (DOX), camptothecin (CPT), 5-FU, and curcumin (Cur), which are employed in the treatment of many cancers, including CRC [ 217 ]. However, chemotherapeutics have a number of limitations in their use, including rapid clearance after administration, non-specific distribution, and non-discriminatory damage to normal tissues [ 218 ]. As a result, scientists have been working for a long time to develop a drug carrier that can precisely control the on-demand release of chemotherapeutics in order to increase targeting to tumor tissues and improve therapeutic efficacy.…”