Cover Feature: Comparison of Bioorthogonal β‐Lactone Activity‐Based Probes for Selective Labeling of Penicillin‐Binding Proteins (ChemBioChem 1/2021)

Abstract

Decision tree: The cover feature depicts the decision making process for designing bioorthogonal probes for activity‐based protein profiling. Each “branch” presents its own complexities and considerations to produce a probe most appropriate for the given application. The development of selective, bioorthogonal activity‐based probes for penicillin‐binding proteins in Streptococcus pneumoniae highlights these concerns, with emphasis on linker length and environment in which the bioorthogonal reaction is applied. More information can be found in the full paper by E. E. Carlson et al.. Image created with Biorender.