Cover Image: Naevus sebaceus affected by overgrowth of <i>Malassezia globosa</i>

Pradhan, Sushmita; Ran, Xin; Zhang, C.; Li, X.; Ran, Yuping

doi:10.1111/bjd.17155

Cited by 3 publications

(2 citation statements)

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“…have also been tied to atopic dermatitis, and recent studies have shed light on how orchestration of anti-fungal immunity may go awry to promote IL-17 and IL-23-dependent inflammation under conditions of barrier impairment (Sparber et al, 2019). Furthermore, unchecked colonization by M. globosa and M. restricta can result in pityriasis, skin that is considered to be infected and characterized by rash and inflammatory signals, such as skin redness and thickening (Pradhan et al, 2018). Finally, M. furfur is an emerging culprit in invasive fungal infections in infants (Chen et al, 2020).…”

Section: Staphylococcus Epidermidis: a Model Commensal To Probe Homeomentioning

confidence: 99%

The Skin Microbiota: Balancing Risk and Reward

Flowers

Grice

2020

Cell Host & Microbe

155

110

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The skin microbiome is an ecosystem comprised of a multitude of microbial species interacting with their surroundings, including other microbes and host epithelial and immune cells. These interactions are the basis of important roles within the skin microbiome that provide benefit to the host, boosting multiple aspects of barrier function, a critical function of this essential organ. However, with reward always comes risk; resident skin microbes function in a context-dependent manner, set on the backdrop of a dynamic host and microbial milieu. Here, we discuss the reward of hosting a microbial ecosystem on the skin, including protection from pathogens and tuning of the skin microenvironment. We also give consideration to how these skin residents, often termed ''commensals'' can cause disorder, damage, and promote skin disease.

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Section: Staphylococcus Epidermidis: a Model Commensal To Probe Homeomentioning

confidence: 99%

The Skin Microbiota: Balancing Risk and Reward

Flowers

Grice

2020

Cell Host & Microbe

155

110

View full text Add to dashboard Cite

show abstract

“…For example, Malassezia is the predominant skin fungus in humans and is commonly observed on the skin of the face, scalp, and outer ears, which is rich in sebaceous glands ( 50 ). Despite having a clear correlation to skin diseases such as dandruff ( 51 , 52 ), atopic dermatitis ( 53 ), and pityriasis ( 54 ), Malassezia species can also promote skin health like other skin-resident microbes by competing with the pathogen Staphylococcus aureus , secreting proinflammatory cytokines ( 55 , 56 ), dissociating biofilms ( 57 ), and so on ( 58 ). Alternaria and Cladosporium were the dominant fungal genera in the skin samples.…”

Section: Discussionmentioning

confidence: 99%