Cover Picture: Bulk Electrocatalytic NADH Cofactor Regeneration with Bipolar Electrochemistry (Angew. Chem. Int. Ed. 3/2022)

Abstract

Bipolar electrochemistry , symbolized by the two electrodes at the opposite sides of the picture, can trigger the bioelectrocatalytic reduction of the important enzymatic cofactor NAD+, as reported by Lin Zhang, Alexander Kuhn et al. in their Communication (e202111804). The reaction occurs on the negatively polarized side—indicated by the δ− sign—of surface‐modified catalytically active beads—illustrated by the planets—suspended in the bulk phase of an electrolyte. This wireless electrochemical approach allows a systematic tuning of the increase in conversion efficiency.

Engineering ketoreductases for the enantioselective synthesis of chiral alcohols

“…The most widely used GDH demonstrates the highest activity (up to 550 U g −1 ) and stability, however, it generates stoichiometric amounts of the water-soluble co-product gluconic acid which can also require extra downstream treatment costs. 143 In the ongoing general trend towards the use of electrons and photons instead of reagents, in a sustainable low carbon economy, 144 electrochemical, 145 and photolytic 146 cofactor regeneration are emerging methodologies. Despite being dependent on electron mediators for effective 1,4-NAD(P)H regeneration efficiency, both types of regenerative systems are robust, easy-to-assemble components that, if they are recyclable, give them potential for large-scale integrated processes including continuous flow.…”

Water‐Degradable Oxygen‐Rich Polymers with AB/ABB Units from Fast and Selective Copolymerization

“…[33,34] Our group recently reported the copolymerization of 1,3dioxolane and cyclic anhydrides to synthesize thermal stable poly(ester-co-acetal), but with an undefined polymer structure due to the transacetalization reaction. [35] Moreover, degradation of acetal-containing polymers invariably occurs in acidic aqueous solutions that are hazardous to the environment. Overall, polymers that can be fully decomposed into value-added small molecules under environmentally benign conditions are still rare.…”

“…Hillmyer and co‐workers reported the cationic ring‐opening polymerization of cyclic hemiacetal esters to synthesize acid‐labile poly(ester‐ co ‐acetal) [33,34] . Our group recently reported the copolymerization of 1,3‐dioxolane and cyclic anhydrides to synthesize thermal stable poly(ester‐ co ‐acetal), but with an undefined polymer structure due to the transacetalization reaction [35] . Moreover, degradation of acetal‐containing polymers invariably occurs in acidic aqueous solutions that are hazardous to the environment.…”

Efficient Removal of Mercury from Polluted Aqueous Solutions Using the Wireless Bipolar Electrochemistry Technique

“…The concept of bipolar electrochemistry has been adapted for metals electrodeposition on carbon substrates, [21][22][23][24] (Bio)electroanalysis, [25] electrocatalysis, [26][27] bioelectrocatalysis, [28] and electrosynthesis of various organic, inorganic, [29] and polymeric [30] materials. So far, bipolar electrochemistry has never been adapted for mercury depollution purposes.…”