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Winters, Carmen; Machan, Mac; Liu, Deede; Fraga, Garth

doi:10.1111/cup.12080

Cited by 11 publications

(3 citation statements)

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“…More recently, multinucleated keratinocytes with up to 16 nuclei per cell were noted in a biopsy of a patient with factitial disorder. 7 …”

Section: Discussionmentioning

confidence: 99%

“… 3 Other authors have suggested that these results are from cell–cell fusion of adjacent keratinocytes rather than mitotic malfunction, as evidenced by a relative lack of expression in Ki-67, a marker of cell activity. 7 …”

Section: Discussionmentioning

confidence: 99%

“… 6 – 8 Mitotic rate can be increased in multinucleated and mononuclear epithelial cells but not as significantly as seen in neoplastic processes. 6 , 7 We propose the name “grape cells” for multinucleated keratinocytes because of their distinct histology that reminds us of a cluster of grapes. It is important to note that although this finding is indicative of external manipulation, any underlying inflammatory, infectious, or neoplastic processes should be excluded.…”

Section: Discussionmentioning

confidence: 99%

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Grape Cells (Multinucleated Keratinocytes) in Noninfectious Dermatoses

Sweeney

Sulit

Adams

et al. 2015

The American Journal of Dermatopathology

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Abstract:Multinucleated keratinocytes (also known as multinucleated epidermal giant cells) are a frequently overlooked histological finding in noninfectious inflammatory dermatoses. They are sometimes found in conditions characterized by chronic rubbing and pruritus, such as lichen simplex chronicus or prurigo nodularis, and may be a helpful clue in making the clinical diagnosis. This finding must be differentiated from other conditions characterized by multinucleated keratinocytes on histopathology, specifically herpes simplex, varicella zoster, or measles viral infections. The authors present a case series of 2 patients with unique clinical noninfectious diagnoses but similar histopathologic findings on biopsy. The histopathologic findings on both cases demonstrated multinucleated keratinocytes, which were related to manipulation of the epidermis.

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“…More recently, multinucleated keratinocytes with up to 16 nuclei per cell were noted in a biopsy of a patient with factitial disorder. 7 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%