Misinformation that accompanied the current SARS-CoV-2 pandemic led to an impaired risk perception, resulting in the refusal of personal protection measures, as well as a reduced willingness to receive a vaccination. In order to identify factors that might influence people’s attitudes towards COVID-19 policies and engagement in mitigation measures, we carried out a cross-sectional study in Germany. Altogether, n = 808 participants completed our questionnaire concerning items on demographics, media consumption, risk perception, and trust in health authorities, as well as willingness to receive a vaccination. An overwhelming majority of our participants perceived SARS-CoV-2 as a health threat (85.7%), and almost two thirds (63.5%) mentioned they would get vaccinated against SARS-CoV-2 when a vaccination was available. A greater likelihood of vaccination intention was associated with being male (71.5% male vs. 60% female, p < 0.05), left-wing voting, trusting health authorities, using public media as an information source about COVID-19, and, in particular, perceiving COVID-19 as a health threat. A better understanding of factors that contribute to vaccine hesitancy is indispensable in order to eliminate doubts, increase vaccination rates, and create herd immunity, to stop further virus transmission.