COVID-19, acute respiratory distress syndrome (ARDS), and hyperbaric oxygen therapy (HBOT): what is the link?

Maio, Antonio De; Hightower, Lawrence E.

doi:10.1007/s12192-020-01121-0

Cited by 33 publications

(37 citation statements)

References 32 publications

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“…HBO 2 allows the delivery of oxygen at high partial pressure reaching tissues rapidly at elevated concentrations, which could reverse the hypoxic condition and preserve cellular metabolism [22] . Indeed, HBO 2 has been shown to preserve mitochondrial activity [23] .…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?

Kjellberg¹,

Maio²,

Lindholm³

2020

Medical Hypotheses

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Introduction SARS-CoV-2 affects part of the innate immune response and activates an inflammatory cascade stimulating the release of cytokines and chemokines, particularly within the lung. Indeed, the inflammatory response during COVID-19 is likely the cause for the development of acute respiratory distress syndrome (ARDS). Patients with mild symptoms also show significant changes on pulmonary CT-scan suggestive of severe inflammatory involvement. Hypothesis The overall hypothesis is that HBO 2 is safe and reduces the inflammatory response in COVID-19 pneumonitis by attenuation of the innate immune system, increase hypoxia tolerance and thereby prevent organ failure and reduce mortality. Evaluation of the hypothesis HBO 2 is used in clinical practice to treat inflammatory conditions but has not been scientifically evaluated for COVID-19. Experimental and empirical data suggests that HBO 2 may reduce inflammatory response in COVID-19. However, there are concerns regarding pulmonary safety in patients with pre-existing viral pneumonitis. Empirical data Anecdotes from “compassionate use” and two published case reports show promising results. Consequences of the hypothesis and discussion Small prospective clinical trials are on the way and we are conducting a randomized clinical trial.

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Section: Evaluation Of the Hypothesismentioning

confidence: 99%

Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?

Kjellberg¹,

Maio²,

Lindholm³

2020

Medical Hypotheses

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“…Decreased hypoxiainducible factor 1α (HIF-1α) could hamper SARS-COV-2 viral replication due to early and proper oxygen therapy [38]. Delivery of 100% oxygen under increased atmospheric pressure up to 2.4 atm through hyperbaric oxygen therapy (HBOT) could improve the patients' outcome if administered at the earliest stages of the COVID-19 infection when arterial oxygen concentration has just been noticed reducing [39].…”

Section: Discussionmentioning

confidence: 99%

RT-PCR Mediated Identification of SARS-CoV-2 Patients from Particular Regions of Bangladesh and the Multi-factorial Analysis Considering Their Pre and Post Infection Health Conditions

Akter

Tushi

Mily

et al. 2020

BJI

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Background: SARS-CoV-2 is a type of coronavirus shows bizarre features with fatality rates at 34.4%. The clinical and non-clinical features of COVID-19 might be causative factors for more rapid community spreading compared to MERS and SARS-CoV-1. Objectives: To study the efficacy of RT-PCR based detection of SARS-CoV-2 patients. Besides, the patients' pre and post-infection health conditions depending on selective clinical and nonclinical parameters were analyzed. Materials and Methods: Clinical and non- clinical data were collected from 205 randomly selected COVID-19 patients, identified through RT-PCR from different areas of Bangladesh. The data were analyzed using statistical and analytical tools to illustrate the impact of the pandemic situation on the sufferers. Results: Molecular identification of the patients through RT-PCR has been observed as the most efficient option for detecting SARS-CoV-2 patients. Patients with the smoking habit have been reported to be more prone to the COVID-19 infection; surprisingly the non-smoker female was the worse suffers. The patients aged 60-69 years were the worst sufferers with every adverse health conditions mentioned. Professionally, 28% self-employed male and 8.19% female were infected. The most infected individuals were house wife (32.029%), as next to the health care workers (22.1%). With the increased age group, a decreased number of smokers were found. Nebulization of 5% home and 12% hospital treated patients were provided, with Oxygen for 26% of hospitalized patients. After recovery, combined physical and psychological complications were observed in 19% of male and 11% female. The socioeconomic, environmental and geographical annotations exposed a clear relationship with the rate of infection as revealed from the nonclinical data analysis. Conclusion: RT-PCR proved its specialty in COVID-19 detection. In addition, impacts of different clinical and nonclinical factors on the physical conditions of the nCoV patients were found significant in the research.

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“…Therefore, early therapeutic interventions could be critical to ameliorating the outcome from COVID-19. A potential intervention, particularly in conditions of low oxygen saturation levels, is hyperbaric oxygen treatment, consisting of systemic exposure to 100% oxygen under increased atmospheric pressure (De Maio and Hightower 2020 ; Kjellberg et al 2020 ), which appears to be successful in limited clinical trials (Gorenstein et al 2020 ; Thibodeaux et al 2020 ).…”

Section: Organismal and Intercellular Level Stress Responsesmentioning

confidence: 99%

First Virtual International Congress on Cellular and Organismal Stress Responses, November 5–6, 2020

Oosten-Hawle

Bergink

Blagg

et al. 2021

Cell Stress and Chaperones

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Members of the Cell Stress Society International (CSSI), Patricija van Oosten-Hawle (University of Leeds, UK), Mehdi Mollapour (SUNY Upstate Medical University, USA), Andrew Truman (University of North Carolina at Charlotte, USA) organized a new virtual meeting format which took place on November 5–6, 2020. The goal of this congress was to provide an international platform for scientists to exchange data and ideas among the Cell Stress and Chaperones community during the Covid-19 pandemic. Here we will highlight the summary of the meeting and acknowledge those who were honored by the CSSI.

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COVID-19, acute respiratory distress syndrome (ARDS), and hyperbaric oxygen therapy (HBOT): what is the link?

Cited by 33 publications

References 32 publications

Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?

Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?

RT-PCR Mediated Identification of SARS-CoV-2 Patients from Particular Regions of Bangladesh and the Multi-factorial Analysis Considering Their Pre and Post Infection Health Conditions

First Virtual International Congress on Cellular and Organismal Stress Responses, November 5–6, 2020

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