COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality

Sharma, Prateek; Behl, Tapan; Sharma, Neelam; Singh, Sukhbir; Grewal, Ajmer Singh; Albarrati, Ali; Albratty, Mohammed; Meraya, Abdulkarim M.; Bungău, Simona

doi:10.1016/j.biopha.2022.113089

Cited by 65 publications

(51 citation statements)

References 108 publications

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“…Clinically, COVID-19 is manifested by a diversity of symptoms, the most frequent being fever and respiratory symptoms (14). Cardiovascular, hematological, central nervous, gastrointestinal (GI), hepatobiliary, and renal systems are all affected by COVID-19, due to the presence of angiotensin-converting enzyme 2 (ACE2) receptors in all these organs (15)(16)(17)(18). Approximately one-third of all cases are clinically asymptomatic (19), but the rest are classified as mild, moderate, severe, and critical.…”

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confidence: 99%

Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

Sava

Bodog

Niulas

et al. 2022

In Vivo

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Background/Aim: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for generating a global pandemic with deadly consequences and life changes worldwide. With the appearance of the new variants of the virus, clinical manifestations have been reported in the pediatric population, some with severe evolution. The aim of this study was to identify the laboratory parameters necessary to establish an effective therapy. Patients and Methods: In the period from August 2020 to September 2021, 234 pediatric patients met the inclusion criteria and were selected for the study. After confirming the COVID-19 diagnosis, laboratory parameters were analyzed and compared to the severity of the illness. Results: Thrombocytopenia (p<0.001), leukocytosis (p<0.001), and lymphopenia (p<0.001) correlated with the severity of the disease. Also, D-dimer values were closely monitored due to the high association of this parameter with an unsatisfactory prognosis and a severe form of the disease. Conclusion: The D-dimer values and complete blood count are useful parameters in COVID-19 evaluation in children.

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mentioning

confidence: 99%

Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

Sava

Bodog

Niulas

et al. 2022

In Vivo

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“…De Almeida-Pititto [ 46 ] concluded the association of diabetes with COVID-19 results in a 2.5-fold increase in mortality and a 2.3-fold increase in severity. Another important finding raised by Rathmann and colleagues [ 47 ] suggested the increased incidence of type 2 diabetes in patients with COVID-19 after recovery from infection, which could be explained by the association of COVID-19 infection with insulin resistance and new-onset hyperglycemia in patients without previous diabetes [ 48 ]. Furthermore, Sharma and colleagues [ 48 ] attributed the new-onset diabetes to direct pancreatic cell damage induced by the COVID-19 infection and aggravating the hyperglycemic status, causing new-onset diabetes.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Case Management Outcomes Amongst Diabetes and Hypertensive Patients in the United Arab Emirates: A Prospective Study

Alkhemeiri

Zaabi

Lakshmanan

et al. 2022

IJERPH

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The global pandemic of the novel Coronavirus infection 2019 (COVID-19) challenged the care of comorbid patients. The risk imposed by COVID-19 on diabetes patients is multisystemic, exponential, and involves glucose dysregulation. The increased burden for diabetes patients infected with COVID-19 is substantial in countries with a high prevalence of diabetics, such as the United Arab Emirates (UAE). This study aims to explore the prevalence of diabetes, clinical characteristic, and outcomes of patients admitted for COVID-19 treatment with or without a concurrent preadmission diagnosis of diabetes. A prospective study was performed on 1199 adults admitted with confirmed COVID-19 from December 2020 to April 2021 to a single hospital in the UAE. The study compared the demographics, clinical characteristics, and outcomes in COVID-19-infected patients with diabetes to patients without diabetes. The study endpoints include the development of new-onset diabetes, admission to ICU, trends in the blood glucose levels, and death. A total of 1199 patients (390 with diabetes) were included in the study. A diabetes prevalence was detected among 9.8% of the study population. Among the diabetes group, 10.8% were morbidly obese, 65.4% had associated hypertension, and 18.9% had coronary artery disease. Diabetes patients showed higher rates of ICU admission (11.1% vs. 7.1%), NIV requirement (9.6% vs. 6.4%), and intubation (5.45% vs. 2%) compared to the non-diabetes group. Advanced age was a predictor of a worsening COVID-19 course, while diabetes (p < 0.050) and hypertension (p < 0.025) were significant predictors of death from COVID-19. Nearly three-fourths (284 (73.4%)) of the diabetic patients developed worsened hyperglycemia as compared to one-fifth (171 (20.9%)) of the nondiabetic patients. New-onset diabetes was detected in 9.8% of COVID-19 patients. COVID-19 severity is higher in the presence of diabetes and is associated with worsening hyperglycemia and poor clinical outcomes. Preexisting hypertension is a predictor of COVID-19 severity and death.

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“…However, evidence suggests that the SARS-CoV-2 genome lacks the HE gene [2] , [3] , [4] , [5] , [6] . In addition, the authors did not presented envelope protein in structure of SARS-CoV-2 in [1] .…”

mentioning

confidence: 96%

“…Sharma et al presented hemagglutinin esterase as a structural protein on the SARS-CoV-2 surface in a recent review article in Biomedicine & Pharmacotherapy [1] . However, evidence suggests that the SARS-CoV-2 genome lacks the HE gene [2] , [3] , [4] , [5] , [6] .…”

mentioning

confidence: 99%

“…COVID-19 is caused by SARS-CoV-2, a beta-coronavirus of lineage B. It encodes four structural proteins: [1] the spike-surface glycoprotein [2] , the small envelope protein [3] , the membrane glycoprotein, and [4] the nucleocapsid protein, as well as several nonstructural proteins; however, HE is encoded by other betacoronaviruses in lineage A, including HCoV-OC43, HCoV-HKU1, BCoV, and MHV [2] , [8] .…”

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confidence: 99%

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Comment on “COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality.”

Adli

Rahimi

2022

Biomedicine & Pharmacotherapy

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COVID-19 and diabetes: Association intensify risk factors for morbidity and mortality

Cited by 65 publications

References 108 publications

Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

COVID-19 Case Management Outcomes Amongst Diabetes and Hypertensive Patients in the United Arab Emirates: A Prospective Study

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