COVID-19 and Fatal Sepsis Caused by Hypervirulent <i>Klebsiella pneumoniae</i>, Japan, 2020

Hosoda, Tomohiro; Harada, Sohei; Okamoto, Koh; Ishino, Sumire; Kaneko, Makoto; Suzuki, Masahiro; Ito, Ryo; Mizoguchi, Miyuki

doi:10.3201/eid2702.204662

Cited by 39 publications

(37 citation statements)

References 15 publications

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“…Therefore, K. pneumoniae infections, especially due to hypervirulent strains, may have the potential to complicate the course of COVID-19. Colonization by this pathogen is an established risk factor for invasive disease ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Coinfections with Other Respiratory Pathogens among Patients with COVID-19

et al. 2021

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Coinfections in COVID-19 patients may worsen disease outcomes and need further investigation. We found that a higher proportion of patients with COVID-19 were coinfected with one or more additional pathogens. A better understanding of the prevalence of coinfection with other respiratory pathogens in COVID-19 patients and the profile of pathogens can contribute to effective patient management and antibiotic stewardship during the current pandemic.

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Section: Discussionmentioning

confidence: 99%

Coinfections with Other Respiratory Pathogens among Patients with COVID-19

et al. 2021

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“…Since the beginning of the pandemic, several authors have reported the association between COVID-19 and carbapenemase-secreting Klebsiella , stressing that these infections may have the potential for seriously complicating the course of COVID-19 [ 16 ]. In a study published by Montrucchio et al, the presence of a carbapenemase-producing coinfection with Klebsiella pneumoniae was correlated with the presence of comorbidities such as hypertension, asthma, smoking and obesity and the administration of corticosteroids and tocilizumab, as well as a previous administration of broad-spectrum antibiotics [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Carbapenem-Resistant Klebsiella pneumoniae Associated with COVID-19

Dumitru

Dumitrașcu²,

Vlad

et al. 2021

Antibiotics

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Infections with carbapenem-resistant Enterobacteriaceae are emerging as an important challenge in healthcare settings. Currently, carbapenem-resistant Klebsiella pneumoniae (CRKP) are the species of CRE most commonly encountered in hospitals. CRKP is resistant to almost all available antimicrobial agents, and infections with CRKP have been associated with high rates of morbidity and mortality, particularly among persons with prolonged hospitalization exposed to invasive devices. We report nine patients hospitalized in an intensive care unit (ICU) with severe coronavirus disease 2019 (COVID-19) who developed invasive infections due to carbapenemase-producing Klebsiella pneumoniae (CP-Kp), KPC and OXA-48, strains that have not been previously identified in our hospital. Despite ceftazidime/avibactam therapy, five patients died. Coinfections can contribute to a poor prognosis for patients with COVID-19, especially for high-risk populations such as elderly patients. Therefore, it is crucial to establish a rigorous program of antibiotic administration in intensive care units.

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“…However, cases of CoNS bloodstream infections (BSI) and catheter-related bloodstream infections (CRBSI) have been reported among patients with COVID-19 [13]. At the same time, Klebsiella pneumoniae has been associated with several nosocomial outbreaks and occurs in patients alongside new coronavirus infection [18,29,42,43].…”

Section: Discussionmentioning

confidence: 99%

Contamination of Hospital Surfaces with Bacterial Pathogens under the Current COVID-19 Outbreak

Pochtovyi

Vasina

Kustova

et al. 2021

IJERPH

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The SARS-CoV-2 pandemic remains a global health issue for several reasons, such as the low vaccination rates and a lack of developed herd immunity to the evolution of SARS-CoV-2, as well as its potential inclination to elude neutralizing antibodies. It should be noted that the severity of the COVID-19 disease is significantly affected by the presence of co-infections. Comorbid conditions are caused not only by pathogenic and opportunistic microorganisms but also by some representatives of the environmental microbiome. The presence of patients with moderate and severe forms of the disease in hospitals indicates the need for epidemiological monitoring of (1) bacterial pathogens circulating in hospitals, especially the ESKAPE group pathogens, and (2) the microbiome of various surfaces in hospitals. In our study, we used combined methods based on PCR and NGS sequencing, which are widely used for epidemiological monitoring. Through this approach, we identified the DNA of pathogenic bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, CoNS, and Achromobacter spp.) on various surfaces. We also estimated the microbiome diversity of surfaces and identified the potential reservoirs of infections using 16S rRNA profiling. Although we did not assess the viability of identified microorganisms, our results indicate the possible risks of insufficient regular disinfection of surfaces, regardless of department, at the Infectious Diseases Hospital. Controlling the transmission of nosocomial diseases is critical to the successful treatment of COVID-19 patients, the rational use of antimicrobial drugs, and timely decontamination measures.

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COVID-19 and Fatal Sepsis Caused by Hypervirulent Klebsiella pneumoniae, Japan, 2020

Cited by 39 publications

References 15 publications

Coinfections with Other Respiratory Pathogens among Patients with COVID-19

Coinfections with Other Respiratory Pathogens among Patients with COVID-19

Carbapenem-Resistant Klebsiella pneumoniae Associated with COVID-19

Contamination of Hospital Surfaces with Bacterial Pathogens under the Current COVID-19 Outbreak

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