COVID-19 and the Kidneys: An Update

Benedetti, Claudia; Waldman, Meryl; Zaza, Gianluigi; Riella, Leonardo V.; Cravedi, Paolo

doi:10.3389/fmed.2020.00423

Cited by 107 publications

(155 citation statements)

References 126 publications

(201 reference statements)

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“…Furthermore, Coronil mediated inhibition of swim bladder collapse suggests the beneficial role of Coronil in rescue from edema. The extra pulmonary manifestations of SARS-CoV-2 infection include impairment of renal function, severe acute tubular necrosis, and inflammatory cell infiltration [41,42]. In this study, Coronil mediated recovery of SARS-CoV-2 spike protein injected in zebrafish kidneys suggests the role of Coronil in protecting against renal cell necrosis and degeneration.…”

Section: Discussionmentioning

confidence: 53%

Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation

et al. 2020

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Zebrafish has been a reliable model system for studying human viral pathologies. SARS-CoV-2 viral infection has become a global chaos, affecting millions of people. There is an urgent need to contain the pandemic and develop reliable therapies. We report the use of a humanized zebrafish model, xeno-transplanted with human lung epithelial cells, A549, for studying the protective effects of a tri-herbal medicine Coronil. At human relevant doses of 12 and 58 µg/kg, Coronil inhibited SARS-CoV-2 spike protein, induced humanized zebrafish mortality, and rescued from behavioral fever. Morphological and cellular abnormalities along with granulocyte and macrophage accumulation in the swim bladder were restored to normal. Skin hemorrhage, renal cell degeneration, and necrosis were also significantly attenuated by Coronil treatment. Ultra-high-performance liquid chromatography (UHPLC) analysis identified ursolic acid, betulinic acid, withanone, withaferine A, withanoside IV–V, cordifolioside A, magnoflorine, rosmarinic acid, and palmatine as phyto-metabolites present in Coronil. In A549 cells, Coronil attenuated the IL-1β induced IL-6 and TNF-α cytokine secretions, and decreased TNF-α induced NF-κB/AP-1 transcriptional activity. Taken together, we show the disease modifying immunomodulatory properties of Coronil, at human equivalent doses, in rescuing the pathological features induced by the SARS-CoV-2 spike protein, suggesting its potential use in SARS-CoV-2 infectivity.

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Section: Discussionmentioning

confidence: 53%

Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation

et al. 2020

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“…The signaling pathways involved in the kidney disease related to the COVID-19 is unknown, associated with several factors (Benedetti et al 2020 ). Direct cellular infection though ACE2 or cytokine storm syndrome due to virus infection is supposed as a renal involvement mechanism (Naicker et al 2020 ).…”

Section: Covid- 19 and Renal Diseasesmentioning

confidence: 99%

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

et al. 2020

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The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) pandemic. While the common cold symptoms are observed in mild cases, COVID-19 is accompanied by multiorgan failure in severe patients. The involvement of different organs in severe patients results in lengthening the hospitalization duration and increasing the mortality rate. In this review, we aimed to investigate the involvement of different organs in COVID-19 patients, particularly in severe cases. Also, we tried to define the potential underlying mechanisms of SARS-CoV2 induced multiorgan failure. The multi-organ dysfunction is characterized by acute lung failure, acute liver failure, acute kidney injury, cardiovascular disease, and as well as a wide spectrum of hematological abnormalities and neurological disorders. The most important mechanisms are related to the direct and indirect pathogenic features of SARS-CoV2. Although the presence of angiotensin-converting enzyme 2, a receptor of SARS-CoV2 in the lung, heart, kidney, testis, liver, lymphocytes, and nervous system was confirmed, there are controversial findings to about the observation of SARS-CoV2 RNA in these organs. Moreover, the organ failure may be induced by the cytokine storm, a result of increased levels of inflammatory mediators, endothelial dysfunction, coagulation abnormalities, and infiltration of inflammatory cells into the organs. Therefore, further investigations are needed to detect the exact mechanisms of pathogenesis. Since the involvement of several organs in COVID-19 patients is important for clinicians, increasing their knowledge may help to improve the outcomes and decrease the rate of mortality and morbidity.

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“…Systemic effects such as hypotension, positive luid balance and rhabdomyolysis may also lead to acute kidney injury [6]. In a study of 26 autopsies with patients with COVID-19, diffuse erythrocyte aggregation with endothelial damage and obstruction were found in the peritubular and glomerular capillaries [7]. There was also diffuse damage of the proximal tubules with loss of the brush border, vacuolar degeneration and necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…There was also diffuse damage of the proximal tubules with loss of the brush border, vacuolar degeneration and necrosis. It is also thought that kidney disease may be caused by SARS-CoV-2 entering the kidney cells via the ACE-2 receptor, and can cause damage by inducing tubular damage via deposition of MAC complexes on tubules and in iltration CD68+ macrophages in the tubuleinterstitium [7].…”

Section: Discussionmentioning

confidence: 99%

Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius® 90 technology

Rey-Vela¹,

Muñoz²,

Rico-Fontalvo³

et al. 2020

J Clini Nephrol

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Introduction: Acute kidney injury (AKI) is one of the complications associated with severe COVID-19 infection, and it can present in up to 20% to 40% of the cases; of these, approximately 20% will require renal replacement therapy (RRT). Objective: To establish clinical and laboratory characteristics in a group of patients from Colombia with COVID-19 infection and AKI that received intermittent and prolonged RRT with the GENIUS ® 90 technology in between March and July 2020. Design: Cross-sectional study. Results: 78.9% of participants were men and 21.1% were women. The main comorbidities were the following: Hypertension (65.3%), diabetes mellitus (38.9%), obesity (26.3%), cancer (5.3%), Chronic obstructive pulmonary disease (11.6%), cardiovascular disease (23.2%), active smoking (11.6%). 33.7% had chronic kidney disease (CKD) in the average serum creatinine on admission was 4.4 mg/dl. The following infl ammatory markers were elevated: C-reactive protein (CRP), d-dimer and ferritin (20.3 mg/dl, 931mcg/l and 1174 ng/ml, respectively). 63.5% of patients underwent sustained low-effi ciency dialysis (SLED) (6 to 12 hours) and the rest of the patients (36.35%) underwent conventional hemodialysis (less than 4 hours). The mortality of the total patient sample was 36.9%, lower in patients with CKD than in patients with no previous renal disease history (18.7% and 40.1%, respectively). Conclusion: Renal complications are frequent in patients with severe COVID-19. The development of AKI could be an isolated prognostic marker associated with an increase in mortality in patients with COVID-19, and one of the options is intermittent and prolonged RRT with the GENIUS ® 90 system. Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius ® 90 technology

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COVID-19 and the Kidneys: An Update

Cited by 107 publications

References 126 publications

Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation

Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius® 90 technology

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