COVID‐19‐associated coagulopathy in children: A multicenter observational cohort study

Zabeida, Alexandra; Winikoff, Rochelle; Pelland‐Marcotte, Marie‐Claude; Charlebois, Janie; Sabapathy, Christine

doi:10.1002/pbc.30079

Cited by 7 publications

(1 citation statement)

References 24 publications

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“…The reported elevation of Ddimers among infected hospitalized children has been variable ranging between 55.8% and 94.7%. 8,17 Our study has shown that patients with elevated D-dimers at presentation developed severe or critical disease and required monitoring in high dependency or intensive care unit. Patients with higher D-dimers had greater mortality as well.…”

Section: Discussionmentioning

confidence: 96%

D-dimer: a biomarker for predicting disease severity and outcome in hospitalized children with COVID-19 and post COVID multisystem inflammatory syndrome

Saqlain¹,

Bari

Aimen

et al. 2023

Int J Contemp Pediatr

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Background: COVID-19 has presented with varied signs and symptoms with raised inflammatory markers among which D-dimers have been highlighted right from the beginning. Objectives were to analyze the relationship of D-dimers with the disease severity and outcome of children with COVID-19 and MIS-C in a developing country. Methods: It was a retrospective study conducted at a pediatric tertiary care hospital from March 2020 to November 2021. Clinical and laboratory details of confirmed COVID-19 and post COVID-19 MIS-C cases were recorded. D-dimer testing was performed using Chemiluminescence technique. It’s relation with disease severity and predictive role for in-hospital mortality were established by using ROC curves and cut-off values were calculated by using SPSS-24. Results: Of 272 children, 182 were of COVID-19 and 90 were of MIS-C. The mean age for COVID-19 and MIS-C patients was 5.4±4.8 years and 6.4±3.5 years respectively. Mild disease was seen in 33% cases while 17.6% were critical and 56.2% had some under lying comorbidity at presentation. Mean D-dimers were significantly higher in children with severe disease, who required ICU admission and non-survivors as compared to those with mild or moderate disease, not requiring ICU care and survivors, both in COVID-19 and MIS-C patients. ROC curve identified D-dimer value of ≥4.58 µg/ml (AUC=0.845) for COVID-19 cases and ≥4.73 µg/ml (AUC=0.682) for MIS-C patients as predictive of mortality. Conclusions: Raised D-dimer level is a reliable predictor of disease severity and outcome in children with COVID-19 and MIS-C. The D-dimer value of 4.58 µg/ml for COVID-19 cases and 4.73µg/ml for MIS-C patients was found to be the cut-off levels for predicting mortality

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Section: Discussionmentioning

confidence: 96%

D-dimer: a biomarker for predicting disease severity and outcome in hospitalized children with COVID-19 and post COVID multisystem inflammatory syndrome

Saqlain¹,

Bari

Aimen

et al. 2023

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

COVID‐19‐associated coagulopathy in children: A multicenter observational cohort study

Zabeida

Winikoff

Pelland‐Marcotte

et al. 2022

Pediatric Blood & Cancer

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SARS-CoV-2 infection (coronavirus disease 2019 ) induces a stark procoagulant state, with many hospitalized adults developing thrombosis despite prophylactic anticoagulation. This study aimed to characterize hemostatic parameters and associated clinical outcomes of COVID-19, such as thrombosis and bleeding, in children and to assess thromboprophylaxis use. This multicenter observational cohort study included 79 patients aged up to 18 years admitted to all pediatric hospitals in Québec, Canada, with SARS-CoV-2 infection during a 5-month period. D-dimers were elevated in 18/19 patients (94.7%) and fibrinogen in 15/26 patients (60%). Eleven patients (13.9%) received anticoagulant thromboprophylaxis. One thrombotic event and one major bleed were observed.

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Coronavirus disease 2019 (COVID-19) in children: Evolving epidemiology, immunology, symptoms, diagnostics, treatment, post–COVID-19 conditions, prevention strategies, and future directions

Wurm,

Ritz,

Zimmermann

2024

Journal of Allergy and Clinical Immunology

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COVID‐19‐associated coagulopathy in children: A multicenter observational cohort study

Cited by 7 publications

References 24 publications

D-dimer: a biomarker for predicting disease severity and outcome in hospitalized children with COVID-19 and post COVID multisystem inflammatory syndrome

D-dimer: a biomarker for predicting disease severity and outcome in hospitalized children with COVID-19 and post COVID multisystem inflammatory syndrome

COVID‐19‐associated coagulopathy in children: A multicenter observational cohort study

Coronavirus disease 2019 (COVID-19) in children: Evolving epidemiology, immunology, symptoms, diagnostics, treatment, post–COVID-19 conditions, prevention strategies, and future directions

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