COVID-19 aus der Sicht der Gastroenterologie

Abstract

COVID 19, caused by SARS-CoV2, a new variant of coronaviruses, typically presents with respiratory symptoms. However, in a significat number of patients different organs are involved in the disease, often including gastrointestinal symptoms. These could include loss of appetite, vomiting, abdominal pain and diarrhea, with diarrhea being associated with a more severe course of COVID-19. Because viral RNA can be detected in fecal samples, some implications for clinical routine in diagnostic and therapeutic procedures are grown. Until yet, no clear evidence is given regarding fecal-oral transmission of SARS-CoV2.

COVID in children and the digestive system: clinical and pathogenetic correlation

“…Отмечались и тяжелые желудочно-кишечные поражения, такие как перфорация прямой кишки [55], острый панкреатит [56], кровотечение [57], колит [58]. Диарея часто указывала на тяжелый тип воспаления, поэтому она важна для прогноза течения и исхода заболевания [59].…”

“…У пациентов в критическом состоянии воспаление, вызванное вирусной инфекцией, было тяжелым, поражение кишечника усугублялось, а частота острых желудочнокишечных повреждений достигала 86,7%, что часто указывало на более высокий уровень смертности [62]. Это предполагает наличие порочного круга между повреждением кишечника, вызванным SARS-CoV-2, и вызванной им воспалительной реакцией [63,64].…”

Pathogenesis and Mechanism of Gastrointestinal Infection With COVID-19

“…Diarrhea often indicated a severe type of inflammation, so it was more important for the prognosis of patients (67,116,127). Xi's case-control study pointed out that patients with gastrointestinal symptoms had a significantly higher chance of developing critical cases than patients without gastrointestinal symptoms (128), and they were more likely to develop critical diseases such as ARDS, liver injury, and shock (129).…”