COVID-19-Auswirkungen auf die Niere

Amann, Kerstin; Wiech, Thorsten; Singh, Jeeshan; Vonbrunn, Eva; Knöll, Antje; Hermann, M.; Büttner‐Herold, Maike; Daniel, Christel; Hartmann, Arndt

doi:10.1007/s00292-020-00899-1

Cited by 10 publications

(3 citation statements)

References 38 publications

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“…In addition, in silico analysis performed on data sets of single-cell RNA sequencing revealed that RNA of genes that are considered to facilitate SARS-CoV-2 infection (i.e., RNA of ACE-2, transmembrane serine protease 2, and cathepsin L) are predominantly enriched in kidney cells. This enrichment suggested an increased susceptibility of renal cells to SARS-CoV-2 infection [ 234 , 235 ].…”

Section: Renal Implication In Covid-19 Diseasementioning

confidence: 99%

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

Stasi

Franzin

Fiorentino

et al. 2021

IJMS

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High-density lipoproteins (HDLs) are a class of blood particles, principally involved in mediating reverse cholesterol transport from peripheral tissue to liver. Omics approaches have identified crucial mediators in the HDL proteomic and lipidomic profile, which are involved in distinct pleiotropic functions. Besides their role as cholesterol transporter, HDLs display anti-inflammatory, anti-apoptotic, anti-thrombotic, and anti-infection properties. Experimental and clinical studies have unveiled significant changes in both HDL serum amount and composition that lead to dysregulated host immune response and endothelial dysfunction in the course of sepsis. Most SARS-Coronavirus-2-infected patients admitted to the intensive care unit showed common features of sepsis disease, such as the overwhelmed systemic inflammatory response and the alterations in serum lipid profile. Despite relevant advances, episodes of mild to moderate acute kidney injury (AKI), occurring during systemic inflammatory diseases, are associated with long-term complications, and high risk of mortality. The multi-faceted relationship of kidney dysfunction with dyslipidemia and inflammation encourages to deepen the clarification of the mechanisms connecting these elements. This review analyzes the multifaced roles of HDL in inflammatory diseases, the renal involvement in lipid metabolism, and the novel potential HDL-based therapies.

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Section: Renal Implication In Covid-19 Diseasementioning

confidence: 99%

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

Stasi

Franzin

Fiorentino

et al. 2021

IJMS

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“…A possible overinterpretation of postmortem clots as intravital thrombi has been discussed [38,45]. For organ-specific effects of SARS-CoV-2, the authors refer the reader to the relevant articles in this issue [2,3].…”

Section: Morphology Of Organ Damagementioning

confidence: 99%

Detection methods for SARS-CoV-2 in tissue

Stillfried

2021

Pathologe

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Several methods are available for SARS-CoV-2 detection: electron microscopy, antigen detection by immunohistochemistry and immunofluorescence, and nucleic acid detection by in-situ hybridization and reverse transcriptase polymerase chain reaction (RT-PCR). Due to various factors in the preanalytical, analytical, and postanalytical phase, virus detection in pathology material presents specific diagnostic challenge. This article gives an overview of several SARS-CoV-2 detection methods and discusses existing data on specific sources of error, validity, and robustness of these methods.

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“…A collection strategy should be developed and new specimens acquired in order to fill the gaps and to save material for future analysis. With regard to COVID 19, it became clear very rapidly that it was not just a lung disease but that other organs such as the heart [ 66 ] or kidney [ 67 ] are affected. With fast progress in medicine, reference material may be revisited some years later, as is also done currently with specimens from the collections.…”

Section: Discussionmentioning

confidence: 99%

The pathological anatomical collection of the Natural History Museum Vienna

Winter

Teschler-Nicola

Macfelda

et al. 2023

Wien Med Wochenschr

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The pathological anatomical collection Vienna ( Pathologisch-Anatomische Sammlung Wien ; PASW) is a living and still growing research collection. It was established as early as 1796 as part of the Medical University of Vienna, acquired the status of an independent federal museum in 1971, and was assigned to the Natural History Museum Vienna in 2012. It houses a wide range of human wet and dry specimens and further objects, such as moulages, medical devices, microbiological and histological specimens, and a photo archive (approximately 50,000 objects), which, as a meaningful source, may contribute to disclosing not only aspects of the medical history and the development of corresponding museums in Vienna, but is also considered a collection of cultural and current scientific relevance, quite comparable to today’s biobanks. Most of the tissue amassment represents wet organic specimens and human skeletons or skeletal elements representing, e.g., congenital and metabolic disorders, infectious diseases, injuries, neoplasms, or musculoskeletal diseases, basically collected as descriptive anatomical teaching aids. This article reviews the current medical issues on which research has been and is being conducted by including PASW specimens (hereby using the ICD-10 code), and the extent to and ethical conditions under which this important heritage could be used as a reference collection for clinical and bioanthropological (paleopathological and palaeoepidemiological) studies; finally, this article reflects on the value and future research prospects, taking into account different positions and the ongoing discussions in pathological anatomical human tissue collections.

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COVID-19-Auswirkungen auf die Niere

Cited by 10 publications

References 38 publications

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

Detection methods for SARS-CoV-2 in tissue

The pathological anatomical collection of the Natural History Museum Vienna

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