2021
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105915
|View full text |Cite
|
Sign up to set email alerts
|

COVID-19 Encephalitis with SARS-CoV-2 Detected in Cerebrospinal Fluid Presenting as a Stroke Mimic

Abstract: We report the case of a 35-year-old male with COVID-19 encephalitis presenting as a stroke mimic with sudden-onset expressive and receptive dysphasia, mild confusion and right arm incoordination. The patient received thrombolysis for a suspected ischaemic stroke, but later became febrile and SARS-CoV-2 was detected in cerebrospinal fluid. Electroencephalography demonstrated excess in slow waves, but neuroimaging was reported as normal. Respiratory symptoms were absent throughout and nasopharyngeal swab was neg… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
7
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(7 citation statements)
references
References 11 publications
(12 reference statements)
0
7
0
Order By: Relevance
“…All 46 records’ full-texts were obtained and screened for eligibility. Twenty-three articles were excluded for the reasons shown in Figure 1 (citation of those records and full reasoning for exclusion is provided in Table S2 in Supplementary Materials ), and the remaining 23 articles were included in our data synthesis [ 11 , 12 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…All 46 records’ full-texts were obtained and screened for eligibility. Twenty-three articles were excluded for the reasons shown in Figure 1 (citation of those records and full reasoning for exclusion is provided in Table S2 in Supplementary Materials ), and the remaining 23 articles were included in our data synthesis [ 11 , 12 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”
Section: Resultsmentioning
confidence: 99%
“…The following supporting information can be downloaded at: , Table S1: Prisma checklist, search strategy, Table S2: Excluded articles at full-text screening, Table S3: Quality assessment. References [ 11 , 12 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 45 , 48 , 55 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ] are cited in Supplementary Materials.…”
mentioning
confidence: 99%
“…Such encephalitis/encephalopathy has been documented in patients, as shown in Table 1 . 2 , 7 , 8 Language impairment is a relatively frequent symptom that mimics a stroke. The language impairment in our patient might have been elicited by symmetric subcortical lesions attached to the pyramidal tracts in addition to the left facial droop.…”
Section: Discussionmentioning
confidence: 99%
“… 1 Encephalitis/encephalopathy rarely occurs without symptomatic COVID-19. 2 , 3 Stroke incidence without cerebrovascular risk factors is increasing, with a high incidence of large artery ischemia even in young patients. 4 A postmortem examination of a patient with COVID-19 with encephalopathy during the infectious course showed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral particles in both the cytoplasm of frontal lobe neurons and brain endothelial cells.…”
Section: Introductionmentioning
confidence: 99%
“…The first penetration route to the nervous system is through blood circulation [ 25 ]. The following access channels include retrograde axonal transport [ 26 ] and sympathetic afferent neurons of the enteric nervous system (ENS) [ 27 ]. Moreover, the virus might use the synapse-connected route through peripheral nerve terminals of the respiratory network [ 28 ].…”
Section: Introductionmentioning
confidence: 99%