COVID-19 encephalopathy: detection of antibodies against SARS-CoV-2 in CSF

Andriuta, Daniela; Roger, Pierre-Alexandre; Thibault, William C.; Toublanc, B.; Sauzay, Chloé; Castelain, Sandrine; Godefroy, Olivier; Brochot, Étienne

doi:10.1007/s00415-020-09975-1

Cited by 52 publications

(90 citation statements)

References 2 publications

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“… Brun G et al [ 187 ] reported a 54 Y/O F with Multiple supra-tentorial punctiform and tumefactive lesions involving the white matter bilaterally. Demirci Otluoglu G et al [ 196 ] reported a 48 Y/O M with Acute encephalomyelitis and positive CSF for SARS-CoV2 Impaired consciousness, encephalopathy and encephalitis 11 Decreased level of consciousness And Encephalopathy 22 Articles [ 39 ], [ 40 ], [ 57 ], [ 58 ] [ 60 ], [ 62 ] [ 88 ], [ 96 ], [ 98 ], [ 100 ], [ 101 ], [ 133 ], [ 135 ], [ 136 ] [ 137 ], [ 138 ], [ 139 ] [ 140 ], [ 141 ] [ 178 ] [ 184 ] [ 189 ] [ 195 ] [ 197 ] 4,54 NR in all articles. Yin R et al [ 133 ] reported a 64 Y/O M with altered consciousness and Psychiatric symptoms, his brain CT scan was Normal.…”

Section: Resultsmentioning

confidence: 99%

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

186

182

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Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. However, there is growing evidence indicating neurological manifestations occur in patients with COVID-19. Similarly, the other coronaviruses (CoV) epidemics; severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) have been associated with neurological complications. Methods: This systematic review serves to summarize available information regarding the potential effects of different types of CoV on the nervous system and describes the range of clinical neurological complications that have been reported thus far in COVID-19. Results: Two hundred and twenty-five studies on CoV infections associated neurological manifestations in human were reviewed. Of those, 208 articles were pertinent to COVID-19. The most common neurological complaints in COVID-19 were anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported. Conclusion: There are several similarities between neurological complications after SARS-CoV-1, MERS-CoV and COVID-19, however, the scope of the epidemics and number of patients are very different. Reports on the neurological complications after and during COVID-19 are growing on a daily basis. Accordingly, comprehensive knowledge of these complications will help health care providers to be attentive to these complications and diagnose and treat them timely.

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Section: Resultsmentioning

confidence: 99%

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

186

182

View full text Add to dashboard Cite

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“…Several case studies have reported negative tests for viral RNA detection in CSF; however, others have detected SARS-CoV-2 nucleic acid in cerebrospinal fluid of COVID-19 patients who presented with neurological symptoms. 5 – 9 Andrius et al 10 identified the antibodies against protein S1, protein S2, and SARS-CoV-2 nucleoprotein in the CSF of encephalopathy patients. CSF testing for CMV, herpes, and respiratory syncytial virus were negative in our case.…”

Section: Discussionmentioning

confidence: 99%

Encephalopathy as the Presenting Symptom of COVID-19

Hayat¹,

Ahmed²,

Hussain³

et al. 2020

kjm

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“…71 Moreover, infectious toxic encephalopathy is a type of reversible brain dysfunction syndrome that may occur because of SARS-CoV-2 infection, yet further investigations are required. 71,72 Surprisingly, a rare form of encephalopathy called acute hemorrhagic necrotizing encephalopathy has been reported. 73 Peripheral nervous system.…”

Section: Digestive System Manifestationsmentioning

confidence: 99%

Extrapulmonary Clinical Manifestations in COVID-19 Patients

Sarkesh

Sorkhabi

Baghi

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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COVID-19 manifestations in symptomatic patients can be in the form of pneumonia, acute respiratory syndrome, and multiple organ dysfunction as well. Renal complications, gastrointestinal dysfunctions, endocrine system disorders, myocardial dysfunction and arrhythmia, neurological dysfunctions, dermatological symptoms, hematological manifestations, and thromboinflammation are among the reported extrapulmonary complications. Moreover, the presence of coagulopathy, excessive and dysregulated immune responses, and autoimmunity by COVID-19 patients is considerable. The pathogenesis of infection entails the entry of the virus via receptors on cells, principally angiotensin-converting enzyme 2 receptors. Direct virus damage coupled with indirect effects of viral infection including thromboinflammation, dysfunction of the immune system, and dysregulation of the renin-angiotensin system leads to multiple organ failure. This review outlines the extrapulmonary organ-specific complications and their pathophysiology and epidemiology.

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COVID-19 encephalopathy: detection of antibodies against SARS-CoV-2 in CSF

Cited by 52 publications

References 2 publications

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Encephalopathy as the Presenting Symptom of COVID-19

Extrapulmonary Clinical Manifestations in COVID-19 Patients

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