COVID-19 in a tertiary hospital from Romania: Epidemiology, preparedness and clinical challenges

Popescu, Corneliu Petru; Marin, Alexandru Cosmin; Melinte, Violeta; Gherlan, George Sebastian; Banicioiu, Filofteia Cojanu; Dogaru, Adelina; Smadu, Sebastian; Veja, Ana Maria; Nedu, Elena; Stanciu, Delia; Voinescu, Bianca; Simion, Valentina; Toderan, Andreea; Dascălu, Amalia; Oprişan, C; Țârdei, Grațiela; Nica, Maria; Ceauşu, Emanoil; Ruță, Simona; Florescu, Simin Aysel

doi:10.1016/j.tmaid.2020.101662

Cited by 10 publications

(12 citation statements)

References 4 publications

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“…Additionally, the rapid spread of SARS-CoV-2 is closely linked to travel. Therefore, policymakers should monitor incoming travelers and mandate quarantines [ 47 , 51 ]. Our data were not sufficient to recommend medication for RD patients, but we recommended following the guidelines issued by the European League Against Rheumatism (EULAR), which suggested that patients should continue immunosuppressive therapy and immediately seek further healthcare advice of an expert as COVID-19 symptoms worsened [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Risk and clinical outcomes of COVID-19 in patients with rheumatic diseases compared with the general population: a systematic review and meta-analysis

Wang

Shao

et al. 2021

Rheumatol Int

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Patients with rheumatic diseases are often more susceptible to different bacteria and viruses because of immune impairment, but it is not clear whether there is a higher risk of infection and a more serious course of disease for novel coronavirus (SARS-CoV-2). We performed this systematic review and meta analysis to assess the risk and clinical outcomes of COVID-19 in patients with rheumatic diseases compared with the general population. We searched PubMed, EMBASE, Scopus and Web of Science databases from January 1, 2020 to October 20, 2020 to determine epidemiological information related to patients with rheumatic diseases and COVID-19, including clear risk estimate or data that could be converted and extracted. We included 26 observational studies, totaling about 2000 patients with rheumatic diseases of whom were infected with COVID-19. Meta-analysis showed that the risk of COVID-19 infection in rheumatic patients was significantly higher than that in the general population (OR = 1.53, 95% CI 1.24–1.88, P = 0.000). In terms of hospitalization and severe clinical outcomes associated with COVID-19, we found that rheumatic patients showed similar results to the reference population (hospitalization OR = 1.36, 95% CI 0.81–2.29, P = 0.247; admitted to ICU OR = 1.94, 95% CI 0.88–4.27, P = 0.098; death OR = 1.29, 95% CI 0.84–1.97, P = 0.248). The presence of comorbidities, hypertension, lung diseases were significantly associated with the increased risk of COVID-19-related hospitalization in rheumatic patients and anti-TNF drugs were associated with lower hospitalization risk. Older age was related to severe COVID-19. Our meta-analysis indicated that rheumatic patients were at a higher risk of COVID-19 infection but might not lead to a more serious disease process. Supplementary Information The online version contains supplementary material available at 10.1007/s00296-021-04803-9.

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Section: Discussionmentioning

confidence: 99%

Risk and clinical outcomes of COVID-19 in patients with rheumatic diseases compared with the general population: a systematic review and meta-analysis

Wang

Shao

et al. 2021

Rheumatol Int

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“…In less than a year since the identification of the new, highly pathogenic coronavirus SARS-CoV-2, several specific vaccines became available and were deployed to a large part of the population worldwide—an important step toward the end of the pandemic. In Romania, the first case was identified on the 26 February 2020 [ 2 ], and by 21 July there were 1,081,773 confirmed cases, 34,258 deaths, and 1,046,881 recoveries. According to the National Surveillance and Control Centre for Transmissible Diseases, 14,379 cases were registered among healthcare workers (1.3% of the total number of confirmed cases) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Romanian Medical Students’ Attitude towards and Perceived Knowledge on COVID-19 Vaccination

et al. 2021

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In Romania, the first phase of the COVID-19 vaccination campaign prioritized medical personnel, which included healthcare students. This study aimed to assess their knowledge, attitudes towards, and perception of COVID-19 vaccination. An anonymous, single-answer, 42-item online survey was conducted from 12 January until 3 March 2021, in the country’s largest University of Medicine and Pharmacy. Among the 1581 respondents (14.9% response rate), 88.5% were pro-vaccination, 7.8% were undecided, and 3.7% were vaccine resistant. The main reason for vaccine rejection was the perceived speed of vaccine development (strong agreement among the vaccine resistant, moderate agreement among the undecided, p < 0.001). Concern over long-term adverse reaction was present in only 11.5% of the respondents, significantly more frequent in the undecided and vaccine resistant. Perceived knowledge on the vaccines’ safety, efficacy, and technology correlated with a pro-vaccine attitude (p < 0.001). Most respondents had a positive stance towards vaccination in general, influencing their behaviour as future parents (99.3% of the pro-vaccination, 95.1% of the undecided, and 89.1% of the vaccine resistant will vaccinate their children, p < 0.001) and as medical professionals (99.7% of the pro-vaccination, 93.5% of those undecided, and 89.8% of the vaccine resistant would advise parents to vaccinate their children, p < 0.001). Healthcare students can thus serve as important vectors for scientifically sound information, influencing vaccine uptake in the community.

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“…Due to a lack of consensual hospitalization criteria, data about hospitalized patients are heterogeneous. To date, clinical characteristics and outcomes of patients outside China have been reported mostly in Asia, Italy and in the Unites States of America, and mostly for patients admitted to intensive care units (ICU) [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] . Descriptive data about clinical presentation, comorbidities, treatment, and outcomes of hospitalized patients in France are lacking [19] .…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 infection at Toulouse University hospital (France). Results from the Covid-clinic-Toul cohort

Jourdes

Lafaurie

Martin‐Blondel

et al. 2020

La Revue de Médecine Interne

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Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread worldwide from epicenter of Wuhan, China since December 2019. The aim of our study was to describe the clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 pneumonia at the Toulouse university hospital, France. Patients and methods We selected the patients included from March 7, 2020 to April 20, 2020 in the retrolective Covid-clinic-Toul cohort that follows all hospitalized patients with SARS-CoV-2 infection at the Toulouse Hospital. Cases were confirmed by real-time reverse transcriptase polymerase chain reaction. We report demographics, clinical, biological and radiological features, as well as unfavorable outcome at Day 14 after admission (admission in an intensive care unit, mechanical ventilation, death). Results Among 263 hospitalized patients, the median age was 65 years and 155 (58.9%) were males. Two hundred and twenty-seven patients (86.3%) had at least one comorbidity. The median time from first symptom to hospital admission was 7.0 days (interquartile range: 4–10). On day 14 after admission, 111 patients (42.2%) had been transferred to intensive care unit (ICU), including 50 (19.0%) on Day 1; 61 (23.1%) needed mechanical ventilation and 19 patients (7.2%) had died. Patients admitted to ICU at Day 1 of admission ( n = 50) were more frequently men (66.0% vs 57.3%), smokers (25.0% vs 7.1%), with obesity (42.0% vs 24.7%) and had a higher mean level of C-reactive protein (median: 110.9 mg/L vs 46.2 mg/L). Conclusion This cohort provides epidemiological data on SARS-CoV-2 in hospitalized patients in a University hospital in the South of France.

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COVID-19 in a tertiary hospital from Romania: Epidemiology, preparedness and clinical challenges

Cited by 10 publications

References 4 publications

Risk and clinical outcomes of COVID-19 in patients with rheumatic diseases compared with the general population: a systematic review and meta-analysis

Risk and clinical outcomes of COVID-19 in patients with rheumatic diseases compared with the general population: a systematic review and meta-analysis

Romanian Medical Students’ Attitude towards and Perceived Knowledge on COVID-19 Vaccination

Clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 infection at Toulouse University hospital (France). Results from the Covid-clinic-Toul cohort

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