COVID‐19‐induced toxic epidermal necrolysis

Narang, Isha; Panthagani, Anusha P; Lewis, Marissa; Chohan, Bhavna; Ferguson, Amanda; Nambi, Rabi

doi:10.1111/ced.14574

Cited by 15 publications

(14 citation statements)

References 6 publications

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“…4 There were case reports of TEN/SJS associated with COVID-19 infection in adults with probable association with drugs such as hydroxychloroquine, 5 Allopurinol/ Septrin/ Lenalidomide, 6 Lamotrigine, 7 one case with no history of drug exposure. 8 A report of more than 5000 pediatrics patients with COVID-19 infection reported skin manifestations in 0.25% of the cases. Only one patient had SJS with pulmonary involvement and patient deceased.…”

Section: Discussionmentioning

confidence: 99%

Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report

Jouhar

Yahya

Elsiddiq

2022

Clinical Case Reports

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Toxic Epidermal Necrolysis/Steven–Johnson Syndrome (TEN/SJS) is one of the most serious dermatological adverse reactions triggered mainly by drugs and less likely by infections. COVID‐19 disease is caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) with a wide range of clinical manifestations. Skin involvement is common in COVID‐19 patients including urticaria, purpura, and vasculitis. There were reported cases of TEN/SJS in adults with COVID‐19 infections and only two reported cases in pediatric patients. The causality relationship between COVID‐19 infection and TEN/SJS was not established in most cases due to history of drug usage that could be the trigger. In this study, we are reporting a case of previously healthy child apart from COVID‐19 infection who was admitted to the intensive care unit with TEN involving more than 30% of body surface area confirmed by skin biopsy. The child was treated with intravenous immunoglobulins, steroids, and cyclosporin with a very good outcome.

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Section: Discussionmentioning

confidence: 99%

Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report

Jouhar

Yahya

Elsiddiq

2022

Clinical Case Reports

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“…Narang et al reported a case of TEN associated with COVID-19 in a 53-year-old woman with metastatic breast carcinoma. [10] She developed a maculopapular rash, 5 days after receiving a diagnosis of COVID-19, which progressed to TEN after 10 days. The only medication she was receiving at the time of rash was dexamethasone for brain metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike the previous patients who received systemic corticosteroids (the patient with metastatic breast carcinoma was receiving dexamethasone for her brain metastasis) with or without immunoglobulin G, our patient was treated with cyclosporine. [10,11] Guisado-Vasco et al in a retrospective, single-center, observational study in 607 patients, concluded that among the different treatments adopted for COVID-19 (tocilizumab, glucocorticoids, lopinavir/ritonavir, hydroxychloroquine, and cyclosporine), a significant decrease in mortality was associated with cyclosporine alone. [16] They reported that the hyperinflammatory phase in COVID-19 could be reduced by the inhibition of calcineurin inflammatory pathway.…”

Section: Discussionmentioning

confidence: 99%

Toxic epidermal necrolysis and coronavirus disease 2019: A rare association

Pudukadan

John

2021

JSSTD

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Cutaneous manifestations of Coronavirus disease 2019 (COVID-19) are variable. We report a 57-year-old woman who developed toxic epidermal necrolysis (TEN) in association with COVID-19. The patient had not received any drugs prior to the onset of TEN. She responded to treatment with cylosporine. Previous authors have suggested a better prognosis for TEN associated with COVID-19 in comparison to drug-induced TEN.

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“…The present study is a case report of a 77-year-old male with a metabolic, cardiologic and neurological history diagnosed with SARS CoV-2 infection associated with SJS. Few cases have been reported concerning this association, which raises the question of whether, in the case of our patient, SJS appeared independently from COVID-19 or was the primary manifestation of the disease (17)(18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 85%

Concomitance or consequence? Stevens‑Johnson syndrome in COVID‑19: A case report

Manciuc

Lacatusu²,

Vâţă

et al. 2022

Exp Ther Med

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The novel coronavirus infection has been, and still is, a pressing medical problem with a catastrophic effect, not only from a medical point of view, but also from an economic and social one. The cutaneous manifestations of the disease have a diverse morphology and can signal the presence of the infection. The present article reports the case of a 77-year-old male patient admitted at The Sf. Parascheva Clinical Hospital of Infectious Diseases in Iasi (Romania) after testing positive for SARS CoV-2 infection. Initially, the patient presented a pruriginous generalized maculopapular-erythematous eruption with a tendency towards confluence, peri-oro-nasal meliceric crusts and desquamation of the skin on the third anterosuperior and posterior thorax, scalp and forehead, which was accompanied by low back pain, headache and orbital pain. The suspicion of Stevens-Johnson syndrome (SJS) was raised, and treatment was given according to the recommendation of the hospital dermatologist. This association raises multiple questions regarding whether SJS is a cutaneous manifestation of COVID-19 or if there was a concomitance between the viral infection and the immune reaction. The combination of SJS and COVID-19 can have a fatal outcome if not recognized and promptly treated. To our knowledge, this is the first case of SJS in a patient diagnosed with SARS CoV-2 infection in Romania.

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COVID‐19‐induced toxic epidermal necrolysis

Cited by 15 publications

References 6 publications

Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report

Toxic Epidermal Necrolysis associated with COVID‐19 infection: A case report

Toxic epidermal necrolysis and coronavirus disease 2019: A rare association

Concomitance or consequence? Stevens‑Johnson syndrome in COVID‑19: A case report

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