COVID‐19 infection and nocardiosis causing the death of an adolescent with cystic fibrosis

Driscoll, S; Carroll, Will; Nichani, Sanjiv; Fishwick, R; Bakewell, K.; Gilchrist, Francis J

doi:10.1002/ppul.25954

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…The fourth and last case was the fatal case of a 16 years old patient with cystic fibrosis and necrotizing pneumonia due to Nocardia farcinia diagnosed a few days after hospitalization for COVID-19. The patient was treated with antibiotherapy and dexamethasone [ 5 ] .…”

Section: Discussionmentioning

confidence: 99%

“…Occurrence of secondary bacterial pneumonia infections in COVID-19 has been estimated to be around 16% with gram-negative bacteria ( Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Stenotrophomonas maltophilia among others) or with gram-positive bacteria (mainly Staphylococcus aureus ), less frequently (6%) with fungi ( Aspergillus spp or Fusarium spp), and rarely with other opportunistic pathogens such as Pneumocystis jirovecii [ 1 ] . Despite extensive use of steroids and other immunosuppressive drugs in COVID-19 treatment, four cases of nocardiosis during COVID-19 have been reported [ 2 – 5 ] , of which two cases were suspected to be present before COVID-19 infection. We describe a case of pulmonary nocardiosis following critical COVID-19 pneumonia in an 83-year-old male suffering from COVID-19.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary Nocardiosis as an Opportunistic Infection in COVID-19

Laplace

Flamand

Ion

et al. 2022

European Journal of Case Reports in Internal Medicine

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Secondary bacterial pneumonia infection is frequent in COVID-19 patients. Nocardia are responsible for opportunistic pulmonary infections especially after steroid treatment. We describe a case of pulmonary nocardiosis following critical COVID-19 pneumonia in an 83-year-old male. Two weeks after initiation of dexamethasone 6 mg/L, the patient developed a new episode of acute dyspnea. The sputum cultures identified Nocardia cyriacigeorgica. In spite of intravenous imipenem and cotrimoxazole treatment the patient died. Physicians should be aware of the possibility of nocardiosis in case of deterioration of respiratory status of severe COVID-19 inpatients and perform Nocardia evaluation. This evaluation requires prolonged culture.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary Nocardiosis as an Opportunistic Infection in COVID-19

Laplace

Flamand

Ion

et al. 2022

European Journal of Case Reports in Internal Medicine

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“…An English literature review showed only other five reports of these associations. Data regarding these cases are shown [6][7][8][9][10].…”

mentioning

confidence: 99%

Pulmonary nocardiosis after covid-19 infection: case report and literature review

Ortiz¹,

Jover²,

Tabla³

et al. 2023

Rev Esp Quimioter

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hyperinflammation and cytokine storm syndrome in COVID-19 patients. In fact, a recent meta-analysis confirmed that systemic corticosteroids were associated with lower 28-day all-cause mortality compared with usual care or placebo in COVID-19 patients who received oxygen or invasive mechanical ventilation [4].Other conditions that have been associated with nocardiosis include diabetes mellitus, alcoholism, chronic granulomatous disease, alveolar proteinosis, structural lung disease, tumor necrosis factor-alpha inhibitor (e.g., infliximab) therapy, inflammatory bowel disease, chronic obstructive pulmonary disease, and tuberculosis.

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