COVID-19 infection during pregnancy: a systematic review to summarize possible symptoms, treatments, and pregnancy outcomes

Abstract

Background: With the exponential increase in coronavirus disease 2019 worldwide, an increasing proportion of pregnant women are now infected during their pregnancy. The aims of this systematic review were to summarize the possible symptoms, treatments, and pregnancy outcomes of women infected with COVID-19 during their pregnancy.outcomes. The selected articles' results were summarized employing a narrative synthesis approach.Results: A total of nine studies were selected for this study, comprising 101 infected pregnant women. Other than the infected general population, infected pregnant women reported different symptoms; however, fever (66.7%), cough (39.4%), fatigue (15.2%), and breathing difficulties (14.1%) were common. Infected pregnant women were given different treatments than the general infected population. The C-section was a common (83.9%) mode of delivery among infected pregnant women, and a higher proportion of births were preterm births (30.4%) and low birth weight (17.9%).

COVID‐19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes

“…[9][10][11][12] Using four databases (Medline, Web of Science, Scopus, The maternal adverse pregnancy outcomes reported in these studies included spontaneous abortion, 10,11 premature rupture of membranes, 10,12 preterm labor, [9][10][11][12] fetal distress, 12 and cesarean section. [9][10][11][12] Among the neonates of COVID-19 mothers, preterm birth, [9][10][11][12] neonatal asphyxia, 10,12 pneumonia, 9,12 low birth weight, 9,12 stillbirth, and neonatal death 12 have been reported. These adverse pregnancy outcomes can be attributed to the progression of the disease toward the severe stage (ARDS, septic shock, and multiple organ failure) or are linked to the challenge of treating pregnant women considering the effects of certain therapeutic protocols on the fetus.…”

Convalescent plasma therapy in a pregnant COVID-19 patient with a dramatic clinical and imaging response: A case report

“…However, evidence from similar viral infections from the Coronaviridae family such as Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome has indicated more maternal and fetal complications, such as spontaneous miscarriage, intrauterine growth retardation, preterm parturition, maternal renal failure, sepsis, DIC, and even death[ 1 - 3 , 5 ]. Therefore, to reduce probable complications, pregnant women should be monitored for early diagnosis and given appropriate and immediate treatment[ 6 ].…”

COVID‐19 and maternal pre‐eclampsia: A synopsis

“…1 Khan et al, 2020, in their systemic review about positive COVID-19 pregnant women, showed a rate of 29.1% preterm birth and 16.4% low birth weight among their babies. 2 This increases the interest that hyper-inflammatory state in COVID-19 may be associated with hypoxic injury in the placenta and developing pre-eclamptic state.…”