COVID-19 infection: epidemiological, clinical, and radiological expression among adult population

Ragab, Eman; Mahrous, Asrar Helal; Sheikh, Ghadeer Maher El

doi:10.1186/s43055-020-00341-9

Cited by 6 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified that patients in the severe group had significantly higher levels of laboratory biomarkers (CRP, serum ferritin, and D-dimer) compared to patients in the moderate group. This finding is consistent with that reported in other studies [ 19 , 20 ]. Given that, elevated biomarkers can predict respiratory deterioration; they are currently considered markers of poor outcome for COVID-19 patients and caused by associated systemic hyperinflammatory reactions [ 21 ].…”

Section: Discussionsupporting

confidence: 94%

Association between single nucleotide polymorphism of human angiotensin-converting enzyme 2 gene locus and clinical severity of COVID-19

Elbadri

Abdallah

El-Shokry

et al. 2022

Egypt J Med Hum Genet

View full text Add to dashboard Cite

Background Coronavirus disease 2019 (COVID-19) is a devastating pandemic-causing disease with a variable severity among populations. Genetic studies have pinpointed angiotensin-converting enzyme 2 (ACE2), a key enzyme for viral entry, for its possible linkage to the disease progression. The present study aimed to investigate the potential association between single nucleotide polymorphisms (SNPs) of human ACE2 gene with the severity and outcomes of COVID-19 for better patient management. Methods In this observational cross-sectional study, COVID-19 confirmed patients were classified into moderate and severe cases according to the “Ain Shams University Hospitals Pocket Guide for COVID-19 Diagnosis.” Genetic analysis of ACE2 SNP rs2048683 was carried out using a TaqMan assay with the real-time polymerase chain reaction (PCR) technique. Results Among 90 confirmed COVID-19 patients, 78.9% (71/90) were classified as severe, and 21.1% (19/90) were classified as moderate. Laboratory biomarkers were significantly (P = 0.000) higher in the severe group than in the moderate group. Similarly, associated comorbidities such as hypertension were significant (P = 0.000) in the severe group, whereas asthma and deep venous thrombosis were significant in the moderate group (P = 0.007 and 0.006, respectively). Elevated serum ferritin level (odds ratio (OR) 162.589, 95% confidence interval (CI) 8.108–3260.293) and ACE2 rs2048683 genotype GG/G (OR 5.852, 95% CI 1.586–21.591) were both considered independent risk factors for severe disease. Conclusion The findings of the present study provide preliminary evidence of an association between ACE2 rs2048683 SNPs and COVID-19 severity in the Egyptian population, which may inform the need for targeted management.

show abstract

Section: Discussionsupporting

confidence: 94%

Association between single nucleotide polymorphism of human angiotensin-converting enzyme 2 gene locus and clinical severity of COVID-19

Elbadri

Abdallah

El-Shokry

et al. 2022

Egypt J Med Hum Genet

View full text Add to dashboard Cite

show abstract

“…In contrary to our results, Ragab et al[20] reported that crazy paving, septal lines, and lymphadenopathy were more presented in the non-severe cases (87.1%, 81.8 %, 61.1%, respectively). Multivariate regression analysis of the most relevant radiological finding for severity among patients with COVID-19 revealed that GGO with consolidation (OR: 3.52; 95% CI: 1.58-9.63; P = 0.02) and septal thickening (OR: 4.88; 95% CI: (2.13-8.22); P = 0.001) are the most significant finding.…”

contrasting

confidence: 99%

“…At autopsy, it was discovered that the basement membrane of the lung is thicker in diabetic individuals, which may impact pulmonary diffusion function [19]. Furthermore, hypertension patients were more frequently associated with severe COVID-19 pneumonia; it is well recognized that ACE2 is an important regulator of heart activities, which could explain this finding [20]. In this study, significantly low SPO2 and significantly high WBCs, CRP, and ferritin were observed in the severe group.…”

Section: Introductionmentioning

confidence: 51%

Chest Computed Tomographic Imaging Findings and Clinical Criteria of COVID-19 in Zagazig University Hospitals, Egypt

Alsadik

Gad

Abdul-Saboor

et al. 2021

Zagazig University Medical Journal

View full text Add to dashboard Cite

Background: COVID-19 pneumonia patients have variant prognosis and mortality. A great concern should be given to the clinical and imaging characteristics of those patients, As a result, the aim of current research was to identify clinical, laboratory, and chest computed tomography results in confirmed COVID -19 patients, as well as to compare severe patients to non-severe groups. Methods: In a retrospective cross-sectional analysis, 169 confirmed COVID-19 individuals were enrolled. Computerized medical reports and images were used. Results: The enrolled individuals were classified into asymptomatic: 2 patients (1.2%), mild: 33 patients (19.5%), moderate: 103 patients (60.9%) and severe: 31 patients (18.3%). Fever, cough, shortness of breath were significantly more frequent symptoms in severely infected COVID patients (p=0.001). Moreover, a highly significant decrease in SPO2(p=0.00), a remarkable increase in WBCs (p=0.002), and a significant increase in CRP and Ferritin were detected in that group (p=0.00). The chest "high resolution computed tomography findings were associated with multiple lesions in both lungs and more GGO with consolidation (p<0.05). Crazy pavement, septal thickening, and subpleural thickening were also significantly presented in severe COVID pneumonia rather than other groups (p<0.05). Conclusion: Occurrence of clinical factors including aging, cough, fever, dyspnea, comorbidities, hypoxemia, increased WBCs, increased CRP, and ferritin were more prevalent in severe COVID-19 pneumonia. GGO with consolidation and Septal thickening were independent predictors of COVID pneumonia severity findings in HRCT.The use of computed tomography in the diagnosis and assessment of illness severity is crucial.

show abstract

“…The main limitation of this study is the retrospective collection of our data which prevented us from further examining the implication of smoking habits (mild/heavy consumption, current/former) and comorbidities on the detected results. Although we cannot ignore a potential cofounding effect for these variables, many cohorts that accounted for comorbidities in their analysis were still able to declare smoking as an independent risk factor that is not affected by specific characteristics of the patients [ 3 , 30 , 31 ]. Taking into consideration these newly emerging reports and our relatively large size cohort, we anticipate that our results will not be highly affected once adjusted for other comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Questioning the sex-specific differences in the association of smoking on the survival rate of hospitalized COVID-19 patients

et al. 2021

View full text Add to dashboard Cite

Introduction In the absence of a universally accepted association between smoking and COVID-19 health outcomes, we investigated this relationship in a representative cohort from one of the world’s highest tobacco consuming regions. This is the first report from the Middle East and North Africa that tackles specifically the association of smoking and COVID-19 mortality while demonstrating a novel sex-discrepancy in the survival rates among patients. Methods Clinical data for 743 hospitalized COVID-19 patients was retrospectively collected from the leading centre for COVID-19 testing and treatment in Lebanon. Logistic regression, Kaplan-Meier survival curves and Cox proportional hazards model adjusted for age and stratified by sex were used to assess the association between the current cigarette smoking status of patients and COVID-19 outcomes. Results In addition to the high smoking prevalence among our hospitalized COVID-19 patients (42.3%), enrolled smokers tended to have higher reported ICU admissions (28.3% vs 16.6%, p<0.001), longer length of stay in the hospital (12.0 ± 7.8 vs 10.8 days, p<0.001) and higher death incidences as compared to non-smokers (60.5% vs 39.5%, p<0.001). Smokers had an elevated odds ratio for death (OR = 2.3, p<0.001) and for ICU admission (OR = 2.0, p<0.001) which remained significant in a multivariate regression model. Once adjusted for age and stratified by sex, our data revealed that current smoking status reduces survival rate in male patients ([HR] = 1.9 [95% (CI), 1.029–3.616]; p = 0.041) but it does not affect survival outcomes among hospitalized female patients([HR] = 0.79 [95% CI = 0.374–1.689]; p = 0.551). Conclusion A high smoking prevalence was detected in our hospitalized COVID-19 cohort combined with worse prognosis and higher mortality rate in smoking patients. Our study was the first to highlight potential sex-specific consequences for smoking on COVID-19 outcomes that might further explain the higher vulnerability to death from this disease among men.

show abstract

COVID-19 infection: epidemiological, clinical, and radiological expression among adult population

Cited by 6 publications

References 28 publications

Association between single nucleotide polymorphism of human angiotensin-converting enzyme 2 gene locus and clinical severity of COVID-19

Association between single nucleotide polymorphism of human angiotensin-converting enzyme 2 gene locus and clinical severity of COVID-19

Chest Computed Tomographic Imaging Findings and Clinical Criteria of COVID-19 in Zagazig University Hospitals, Egypt

Questioning the sex-specific differences in the association of smoking on the survival rate of hospitalized COVID-19 patients

Contact Info

Product

Resources

About