COVID-19: Is reinfection possible?

Costa, Aratã Oliveira Cortez; Neto, Humberto de Carvalho Aragão; Nunes, Ana Paula Lopes; Almeida, Reinaldo Nóbrega de

doi:10.17179/excli2021-3383

Cited by 3 publications

(1 citation statement)

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“…The question of reinfection quickly rose with the onset of the pandemic, as it was unclear if immunity could be lost [38]. The loss of immunity or the risk of reinfection is an important question in epidemiology, such as for HIV [39].…”

Section: Dynamics Without Protection Measures: Parameters Estimation ...mentioning

confidence: 99%

On Incidence-Dependent Management Strategies against an SEIRS Epidemic: Extinction of the Epidemic Using Allee Effect

2023

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We developed a mathematical model to study the effects of non-pharmaceutical interventions (NPIs) on the dynamics of an epidemic. The level of intervention was assessed as a fraction of the population being isolated and depended on the level of incidence of the epidemic in the population. We performed a mathematical analysis of the model and showed that, depending on the choice of the prevalence-dependent isolation function, it is possible to create new endemic equilibria and to change the stability of the disease-free equilibrium for which the epidemic vanishes. The model was then applied to the case of the COVID-19 pandemic. Several NPI management strategies were considered. In the case of an NPI intensity increasing with the level of infection, it is possible to avoid the initial epidemic peak of great amplitude that would have occurred without intervention and to stabilize the epidemic at a chosen and sufficiently low endemic level. In the case of an NPI intensity decreasing with the level of infection, the epidemic can be driven to extinction by generating an “Allee” effect: when the incidence is below a given level, the epidemic goes extinct whereas, above it, the epidemic will still be able take hold at a lower endemic level. Simulations illustrate that appropriate NPIs could make the COVID-19 vanish relatively fast. We show that, in the context of the COVID-19 pandemic, most countries have not chosen to use the most efficient strategies.

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Section: Dynamics Without Protection Measures: Parameters Estimation ...mentioning

confidence: 99%