In this year, 2020, the Covid-19 pandemic has imposed new challenges for most human activities. Time-geography is a theoretical approach with great potential for analysing the consequences of the new disease and other disturbances, and this article aims at identifying possible developments of interest for the approach in the post-Covid era. The article addresses challenges that emerge for time-geographic research from the perspective of massive changes in human behaviour, regarding time-space activity patterns, caused by the globally diffusing disease. The implications of the pandemic are discussed with respect to four areas: (i) time-geographic techniques; (ii) activities and rhythms; (iii) activity spaces; and (iv) social issues and perceptions. The time-geographic concepts to be scrutinised are constraints, virtual time space and bundles, and stations and paths. In addition, the article introduces this Special Issue of the Moravian Geographical Reports on ‘Current issues, methods and applications in time-geography’, contributions which for evident reasons were written before the onset of the pandemic.