COVID-19 Outcomes of Patients With Differentiated Thyroid Cancer: A Multicenter Los Angeles Cohort Study

Kathuria‐Prakash, Nikhita; Mosaferi, Tina; Xie, Mindy; Antrim, Lauren; Angell, Trevor E.; In, Gino K; Su, Maureen A.; Lechner, Melissa G.

doi:10.1016/j.eprac.2020.12.013

Cited by 14 publications

(15 citation statements)

References 20 publications

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“… 152 However, in differentiated thyroid cancers (DTCs), only older age and comorbidities were statistically associated with COVID-19 severance and hospitalization than thyroid malignancy-related diagnosis, therapy, or disease burden. 153 Furthermore, recent multi-center research revealed that patients with metastatic malignancies had severe COVID-19 while the non-metastatic patients displayed disease events similar to that of non-cancer cases. 154 This observation is yet to be replicated in progressive/metastatic thyroid malignancies.…”

Section: Thyroid Cancer: Potential Impacts During and Post-covid-19 Scenariomentioning

confidence: 99%

SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases

Murugan¹,

Alzahrani²

2021

JIR

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Section: Thyroid Cancer: Potential Impacts During and Post-covid-19 Scenariomentioning

confidence: 99%

SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases

Murugan¹,

Alzahrani²

2021

JIR

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“…Evaluation of non-DTC clinical parameters recognized as risk factors for unfavorable COVID-19 outcomes, including older age, male sex, and medical comorbidities, showed that older age and one comorbidity other than DTC were significantly associated with COVID-19 hospitalization ( p = 0.047 and p = 0.024, respectively). Among patients with DTC, hospitalization related to COVID-19 was more common in patients with DM 2, lung disease, or cardiovascular disease [ 89 ].…”

Section: Discordant Data On the Impact Of Tc On Covid-19 Severity Between Cancer Patients In General And (D)tc Patientsmentioning

confidence: 99%

“…Interestingly, in the retrospective cohort study of 21 patients with DTC and COVID-19 from two academic Los Angeles healthcare systems conducted by Kathuria-Prakash et al, hospitalization was required for more than half of patients (4/7, 57.1%) with a BMI > 30 kg/m 2 as opposed to only 28.6% (4/14) of patients with a lower BMI [ 89 ]. This finding is in consistence with the association of obesity with increased COVID-19 severity in non-cancer COVID-19 patients compared to no obesity [ 12 , 13 ], but contradicts the constantly reported absence of impact of obesity on COVID-19 severity in cancer patients [ 49 , 50 , 51 ].…”

Section: Discordant Data On the Impact Of Tc On Covid-19 Severity Between Cancer Patients In General And (D)tc Patientsmentioning

confidence: 99%

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Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution

Deligiorgi

Siasos

Vakkas

et al. 2021

Cancers

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Background: Conceived of as the “silver lining” of the dark cloud of the coronavirus disease 2019 (COVID-19) pandemic, lessons taught by this catastrophe should be leveraged by medical authorities and policy makers to optimize health care globally. A major lesson is that resilient health systems should absorb sudden shocks incited by overwhelming health emergencies without compromising the continuum of care of chronic diseases, especially of cancer. Methods: The present review dissects the association between COVID-19 and thyroid cancer (TC), especially with differentiated TC (DTC), focusing on available data, knowledge gaps, current challenges, and future perspectives. Results: Obesity has been incriminated in terms of both COVID-19 severity and a rising incidence of TC, especially of DTC. The current conceptualization of the pathophysiological landscape of COVID-19–(D)TC association implicates an interplay between obesity, inflammation, immunity, and oxidative stress. Whether COVID-19 could aggravate the health burden posed by (D)TC or vice versa has yet to be clarified. Improved understanding and harnessing of the pathophysiological landscape of the COVID-19–(D)TC association will empower a mechanism-guided, safe, evidence-based, and risk-stratified management of (D)TC in the COVID-19 era and beyond. Conclusion: A multidisciplinary patient-centered decision-making will ensure high-quality (D)TC care for patients, with or without COVID-19.

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“…Случаи, когда пациенты с РЩЖ были инфицированы COVID-19 и госпитализированы в стационары, уже описаны в литературе. Мультицентровое когорное исследование, проведенное в Лос-Анджелесе, включало 21 больного, госпитализированного с COVID-19 в период с января по сентябрь 2020 года, с ранее диагностированным папиллярным РЩЖ [29]. В настоящий момент данная когорта является самой большой по данной нозологии в мировой литературе.…”

Section: ведение пациентов с патологией щитовидной железы в условиях пандемии Covid-19unclassified

Thyroid Disorders and COVID-19

Petunina¹,

Taravi²,

Surkova³

et al. 2021

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Objective of the Review: To present the available information on the SARS-CoV-2 impact on thyroid gland (TG), impact from a thyroid pathology over COVID-19 morbidity and course, and management of patients with various thyroid pathologies and the novel coronavirus infection. Key Points. SARS-CoV-2 virus demonstrates exponential spread all over the globe and has caused a global pandemic of COVID-19 infection. Currently, the mechanism of non-pulmonary complications of SARS-CoV-2 and endocrine involvement is yet not clear. The impact from SARS-CoV-2 on TG can be a result of direct invasion of target cells by the virus or activation of immunise and inflammatory response.Changes in the pituitary-hypothalamic thyroid system can be caused by developing euthyroid pathology syndrome, glucocorticosteroid therapy, destructive thyroiditis. Manifestation of autoimmune thyroid disorders associated with COVID-19 cannot be ruled out. Conclusion. Currently there is no information on direct thyroid invasion by SARS-CoV-2; however the available results from trials and clinical observations demonstrate possible impact from coronavirus infections, in particular from SARS-CoV and SARS-CoV-2, on the pituitaryhypothalamic-thyroid system with development of various pathologies or a number of changes in thyroid hormone levels. Taking into account possible associations between thyroid dysfunction and prolonged hospitalisation, risk of deaths in hospital, and the association between thyrotoxicosis and atrial fibrillation and hypercoagulation, it is advisable to screen patients with severe COVID-19. Keywords: SARS-CoV-2, COVID-19, thyroid gland, nonsuppurative granulematous thyroiditis.

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COVID-19 Outcomes of Patients With Differentiated Thyroid Cancer: A Multicenter Los Angeles Cohort Study

Cited by 14 publications

References 20 publications

SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases

SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases

Charting the Unknown Association of COVID-19 with Thyroid Cancer, Focusing on Differentiated Thyroid Cancer: A Call for Caution

Thyroid Disorders and COVID-19

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