COVID-19: Transmission, prevention, and potential therapeutic opportunities

Lotfi, Melika; Hamblin, Michael R.; Rezaei, Nima

doi:10.1016/j.cca.2020.05.044

Cited by 863 publications

(748 citation statements)

References 163 publications

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“…The pandemic experienced worldwide due to the novel coronavirus disease 2019 (COVID-19) has created great concerns for health services [1,2] and caused the implementation of public health measures to reduce the spread of the virus [3][4][5], which included limiting human contacts [2]. Consequently, many governments had to regulate social distancing with measures starting in March 2020 that increasingly restricted teaching practices [6].…”

Section: Introductionmentioning

confidence: 99%

Simulated Video Consultations as a Learning Tool in Undergraduate Nursing: Students’ Perceptions

Jiménez-Rodríguez

Arrogante

2020

Healthcare

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Simulated video consultations, a teaching tool based on high-fidelity simulations, were implemented in response to the necessary adaptation of high-fidelity clinical simulation sessions to the online or virtual modality during the university closure due to the COVID-19 confinement. The purpose of our study was to explore the undergraduate nursing students’ satisfaction and perceptions about simulated video consultations using the high-fidelity simulation methodology. A mixed-method was utilized with 93 undergraduate nursing students using a validated satisfaction questionnaire (quantitative data), which included an observations section (qualitative data). Of the total sample, 97.8% of the students expressed a high overall satisfaction with simulated video consultations, highlighting their practical utility and positive learning outcomes. From the students’ comments, two main themes and their related categories emerged: advantages (satisfaction and enjoyment, learning, and calmness during simulated scenarios), and disadvantages (technical issues and technical skills development). Simulated video consultations may be considered as one more high-fidelity simulation teaching option. Nursing students should be trained in this modality of healthcare to face the challenge brought on by its increased use in healthcare services, beyond the specific adaptation of clinical simulation sessions due to the closure of universities during this pandemic.

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Section: Introductionmentioning

confidence: 99%

Simulated Video Consultations as a Learning Tool in Undergraduate Nursing: Students’ Perceptions

Jiménez-Rodríguez

Arrogante

2020

Healthcare

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“…Lessons learned from previous epidemics and pandemics are strategies of implementing modi ed systems including noti cations, isolation precautions, infection prevention, and environmental cleanliness of ICUs [6,8,11,27]. Minimizing the frequency in opening the door of the patient's room was signi cant during the simulation.…”

Section: Critical Care In An Isolation Roommentioning

confidence: 99%

“…The dynamic evolution of the pandemic provides a growing that allows for innovations to optimisations of procedures [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…From December 2019 to March 2020, COVID-19 evolved from a cluster of pneumonia cases in China into the rst coronavirus-caused pandemic [17], surpassing 30.5 million cases and 950,000 deaths in nine months and is still not under control [18]. It is accepted that the COVID-19 virus transmits human-tohuman through respiratory droplets by coughing and sneezing, and aerosols [11]. The disease is highly contagious, with a relatively long incubation period, asymptomatic state, and viral shedding postrecovery.…”

Section: Introductionmentioning

confidence: 99%

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Managing Patients on Extracorporeal Membrane Oxygenation Support During The COVID-19 Pandemic – A Proposal for A Nursing Standard Operating Procedure

Puślecki

Dąbrowski

Baumgart

et al. 2020

Preprint

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Background: Extracorporeal membrane oxygenation (ECMO) therapy is proven to be efficient in a selected critically ill patient population and is showing promising results in refractory hypoxemia in the novel coronavirus disease (COVID-19). However, it necessitates specialized clinicians and advanced technological resources. While COVID-19 is an ongoing global emergency, there is no evidence-based practice in preparedness. This article proposes an innovative and optimized nursing care protocol, the Standard Operating Procedure (SOP), that increase safety, and prevents overuse of personal protective equipment (PPE) without interfering with therapy during ECMO in COVID-19 patients. Methods: A high-fidelity simulation scenario was developed. It included practicing safe and proper PPE donning and doffing during work organization, ECMO cannulation and ECMO-related procedures, and routine daily nursing care and management of patients on ECMO over nine hours. Results: Results were collected in three parts – proposal of nursing standardized operating procedures. They provide including work organization, work load references, competences and infrastructural conditions. Additionally, the cannulation equipment checklist proposal and daily routine nursing algorithm with other procedures during extracorporeal support were created.Conclusions: High-fidelity medical simulation can play an important role in staff training, improvement in previously gained proficiency, and development of optimal SOP for nursing care and management during ECMO in patients with COVID-19. Optimal SOPs may further guide multidisciplinary teams including intensive care units and interventional departments.

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“…The World Health Organization (WHO) reported as of 31 August 2020 more than 25 million con rmed cases of COVID-19 and more than 800,000 death cases globally [3,4]. The virus is transmitted through respiratory droplets or aerosols and direct contact, is characterized by a wide range of symptoms, and patients may experience mild, severe, or critical illness [5]. The overall mortality rate in various countries ranges from 2% to 13% [6,7].…”

Section: Introductionmentioning

confidence: 99%

Severity of COVID-19 Infection in ACEI/ARB Users in Two Saudi Public Specialty Hospitals; Retrospective Cohort Study

Alrashed

Khan

Alhusseini

et al. 2020

Preprint

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The uncertainty about COVID-19 outcomes in angiotensin converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) users continues with contradictory findings. The aim of this study was to determine the effect of ACEI/ARB use in patients with severe COVID-19. This retrospective cohort study done in two Saudi public specialty hospitals designated as COVID-19 referral facilities. We included 354 patients with confirmed diagnosis of COVID-19 between April and June 2020, of which 146 were ACEI/ARB users and 208 were non-ACEI/ARB users. Controlling for confounders, we conducted a multivariate logistic regression and a sensitivity analysis using propensity score matched (PSM) patients. Compared to non-ACEI/ARB users, ACEI/ARB users had an eight-fold higher risk of developing critical or severe COVID-19 (OR=8.25, 95%CI=3.32-20.53); a nearly 7-fold higher risk of intensive care unit (ICU) admission (OR=6.76, 95%CI=2.88-15.89) and a nearly 5-fold higher risk of requiring noninvasive ventilation (OR=4.77,95%CI=2.15-10.55). Patients with diabetes, hypertension, and/or renal disease had a five-fold higher risk of severe COVID-19 disease (OR=5.40,95%CI=2.0-14.54]. These results were confirmed in the PSM analysis. In general, but especially among patients with hypertension, diabetes, and/or renal disease, ACEI/ARB use is associated with a significantly higher risk of severe or critical COVID-19 disease, and ICU care.

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COVID-19: Transmission, prevention, and potential therapeutic opportunities

Cited by 863 publications

References 163 publications

Simulated Video Consultations as a Learning Tool in Undergraduate Nursing: Students’ Perceptions

Simulated Video Consultations as a Learning Tool in Undergraduate Nursing: Students’ Perceptions

Managing Patients on Extracorporeal Membrane Oxygenation Support During The COVID-19 Pandemic – A Proposal for A Nursing Standard Operating Procedure

Severity of COVID-19 Infection in ACEI/ARB Users in Two Saudi Public Specialty Hospitals; Retrospective Cohort Study

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