COVID-19 vaccine induced rhabdomyolysis: Case report with literature review

Nassar, Mahmoud; Chung, Hwa-Jee; Dhayaparan, Yarl; Nyein, Andrew; Acevedo, Bryan Jose; Chicos, Celestin; Zheng, David; Barras, Mathieu; Mohamed, Mahmoud; Alfishawy, Mostafa; Nso, Nso; Rizzo, Vincent; Kimball, E. Robbins

doi:10.1016/j.dsx.2021.06.007

Cited by 51 publications

(50 citation statements)

References 31 publications

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“…Various case reports and case series of unusual adverse events from the vaccines have been published, some of which have proven fatal. One such adverse event is rhabdomyolysis [11,[18][19][20]. Rhabdomyolysis is a potentially life-threatening clinical syndrome that typically results from a skeletal muscle injury, resulting in the release of toxic levels of myoglobin, electrolytes, enzymes such as, creatinine phosphokinase (CPK), aldolase, lactate dehydrogenase, and other substances into the circulating blood [21].…”

Section: Post-vaccination Adverse Eventsmentioning

confidence: 99%

Adverse Events Profile of COVID-19 Preventative Strategies

Ajmera

2022

Encyclopedia

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The COVID-19 pandemic has caused millions of deaths and has affected most people across the world, either directly or indirectly. Many preventative and therapeutic strategies have been employed since the beginning of the pandemic. With the development of the mRNA vaccine within a year of the start of the pandemic, we are entering a new era of vaccinology, and the adverse event profile of the COVID-19 vaccine is also becoming more apparent with time. While the benefits of the vaccines and other preventative strategies certainly outweigh the risk of adverse events, prospective clinical trials are urgently needed to determine whether specific populations, including those with a personal or family history of autoimmune disease, are at higher risk of developing certain adverse events, in order to minimize risk further.

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Section: Post-vaccination Adverse Eventsmentioning

confidence: 99%

Adverse Events Profile of COVID-19 Preventative Strategies

Ajmera

2022

Encyclopedia

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“…During post market surveillance, only a few cases of facial palsy following COVID-19 vaccination have been described [ 50 , 51 ]. Finally, rare cases of vaccine-induced rhabdomyolysis have been reported [ 52 ]. However, it is worth noting that there is currently no evidence denoting a pathogenetic mechanism between COVID-19 vaccines and these entities.…”

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confidence: 99%

Serious complications of COVID-19 vaccines: A mini-review

Fragkou¹,

Dimopoulou²

2021

Metabolism Open

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“…Cases of rhabdomyolysis associated with COVID-19 vaccinations have been reported before (Table 2) [15][16][17]. To our knowledge, this is the first published case of rhabdomyolysis following COVID-19 vaccination with the Ad26.COV2.S vaccine, although similar incidences have been captured in the vaccine adverse event reporting system (VAERS) (Table 3).…”

Section: Discussionmentioning

confidence: 60%

Rhabdomyolysis Following Ad26.COV2.S COVID-19 Vaccination

et al. 2021

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We report the case of a 19-year-old male who complained of myalgia, muscle weakness, and darkened urine two days after receiving his Ad26.COV2.S (Johnson & Johnson, New Brunswick, New Jersey, United States) COVID-19 vaccination. Blood examination revealed an increased creatine kinase (CK) level, and his urinary dipstick tested positive for blood, indicative of acute rhabdomyolysis. Serum creatinine levels were normal. Rhabdomyolysis due to strenuous physical activity was ruled out and further diagnostics excluded an autoimmune cause. Under repeated treatment with intravenous fluid resuscitation (outpatient treatment), his symptoms resolved and peak CK levels of 44,180 U/L returned to almost normal levels within two weeks. Rhabdomyolysis is a rare, potentially fatal vaccine-induced reaction. Further research is needed to better understand the underlying pathomechanism and to investigate whether subcutaneous injection of vaccines may be able to prevent rhabdomyolysis.

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COVID-19 vaccine induced rhabdomyolysis: Case report with literature review

Cited by 51 publications

References 31 publications

Adverse Events Profile of COVID-19 Preventative Strategies

Adverse Events Profile of COVID-19 Preventative Strategies

Serious complications of COVID-19 vaccines: A mini-review

Rhabdomyolysis Following Ad26.COV2.S COVID-19 Vaccination

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