Cow's milk allergy and rolandic epilepsy: a close relationship?

Lucarelli, Sonia; Spalice, Alberto; D'Alfonso, Y.; Lastrucci, G.; Sodano, Simona; Topazio, L.; Frediani, T.

doi:10.1136/archdischild-2011-301424

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…Under a clinical point of view, several authors have tried to demonstrate this link, describing the CNS involvement in atopy,[1234567] highlighting a clinical correlation between seizures and allergy to both inhalants and food.…”

Section: Introductionmentioning

confidence: 99%

Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases

et al. 2016

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Latest research data have emphasized the interaction between the nervous and the immune systems. In this regard, it has been demonstrated that the disruption of the blood–brain barrier (BBB) secondary to peripheral inflammation may play a key role in this relationship. This assumption is linked to recent findings according to which units that constitute the BBB are not only simply neurologic but have also been reconsidered as “neurovascular” elements, through which immune system molecules are vehiculated within the central nervous system (CNS). Herein, we report two cases of food allergy (FA) and one case of infective gastroenteritis, associated with a spectrum of neurologic disorders involving both the CNS and the peripheral nervous system (PNS), postulating some etiopathogenic hypotheses to explain the link between peripheral inflammation and diseases of the nervous system (NS). Three pediatric cases of secondary NS involvement after gastrointestinal (GI) inflammation of different nature have been reported. The first case highlights the link between FA and CNS; the second one is based on a description of a link between GI infection and CNS involvement while the third one describes the relationship between FA and PNS. The importance of these reports relies on the clinical demonstration of a link between the immune system and the NS. The relationship between immune system and NS seems to have pleiotropic aspects, involving different areas of the NS, such as CNS and PNS, which also seem to be in some way interconnected.

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Section: Introductionmentioning

confidence: 99%

Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases

et al. 2016

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“…Epidemiological and ecological data also link cow's milk consumption to higher prevalence of certain cancers (Melnik et al, 2012) and cardiovascular disease (Laugesen & Elliott, 2003). A few studies also related cow's milk to neurological conditions such as epilepsy, autism, and sudden infant death (Lucarelli et al, 2012;Thorsdottir & Thorisdottir, 2011).…”

Section: Discussionmentioning

confidence: 98%

Milk and dairy consumption correlates with cerebral cortical as well as cerebral white matter volume in healthy young adults

Darnai

Plózer

Perlaki

et al. 2015

International Journal of Food Sciences and Nutrition

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The objective of this study was to investigate the relation between habitual milk and dairy consumption and brain morphology as assessed by magnetic resonance imaging (MRI) investigations in 119 young healthy university students. MRI measurements were performed on a Siemens Magnetom Trio Tim (3T) system while FreeSurfer software suite was used for volumetric segmentation. Dietary habits related to milk and dairy consumption were assessed by a structured questionnaire. Total cerebral cortex, total cerebral white matter, and total cerebral parenchyma were significantly related with cottage cheese and total protein intake from milk and dairy also when controlled for age and gender in the multivariate model. Our results indicate that dietary habits related with milk and dairy are proportionally associated with volumes of both cerebral cortex and cerebral white matter.

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“…Egger studied the role of oligo-antigenic diets on 63 children with epilepsy whose seizures ceased during the diet therapy 30 . Lucarelli suggested the role of cow’s milk allergy in children suffering from Rolandic epilepsy with complete clinical remission in 85% of the cases with a cow’s milk free diet and reappearance of the seizures with reintroduction of cow’s milk into diet 31 . Kok et al .…”

Section: Discussionmentioning

confidence: 99%

“…There are growing evidence emphasizing the role of inflammation as the main cause of seizure 8,29 .The proposed mechanisms underlying the peripheral inflammation causing seizure activity indicate the interaction between the nervous and the immune systems 14 and implicate inflammation-related elements including cytokines, endogenous opioids, the nitric oxide signalling pathway and prostaglandins 33 . There are considerable reasons to believe that allergy may act as seizure precipitant in refractory epilepsies 31 .…”

Section: Discussionmentioning

confidence: 99%

Hypoallergenic diet may control refractory epilepsy in allergic children: A quasi experimental study

Gorjipour

Darougar

Mansouri

et al. 2019

Sci Rep

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Recent data has suggested a definitive role for inflammatory processes in the pathophysiology of epilepsy. In this study we hypothesized that food allergies, as chronic inflammatory processes, underlie the pathophysiology of refractory idiopathic epilepsy and investigated whether food elimination diets may assist in managing refractory epilepsy. The study was conducted on 34 patients up to 16 years of age with refractory convulsions who attended the Allergy Outpatient Clinic, Mofid Children Hospital between 2015 and 2016 with youngest and oldest participants at ages of 3 months and 16 years old, respectively. The participants were categorized into three groups according to the results of skin prick test and serum specific IgE measurements. Elimination diets were instituted for the patients with non IgE-mediated and mixed food allergies. The study was conducted for a period of 12 weeks. The participants were assessed for at least 50% reduction in number of seizures following the intervention. There was a significant reduction in number of seizures (p < 0.001) following the intervention. Seventeen patients (50%) did not experience any seizures after 8 weeks of treatment and 12 patients (35%) had a significant (51–99%) decrease in the number of their seizures. Five patients did not show any changes in their daily seizure frequency. The obtained data suggest that food allergy may play a role in triggering refractory epilepsies and their adequate response to treatment. A trial of elimination diet showed more than 50% seizure reduction in more than 85% of the children studied. However, we believe these results are preliminary and they motivate a fully controlled study in the future.

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Cow's milk allergy and rolandic epilepsy: a close relationship?

Abstract: [No abstract available

Cited by 10 publications

References 6 publications

Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases

Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases

Milk and dairy consumption correlates with cerebral cortical as well as cerebral white matter volume in healthy young adults

Hypoallergenic diet may control refractory epilepsy in allergic children: A quasi experimental study

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