Cow’s Milk Protein Allergy as a Model of Food Allergies

Giannetti, Arianna; Vespasiani, Gaia Toschi Toschi; Ricci, Giampaolo; Miniaci, Angela; Palmo, Emanuela di; Pession, Andrea

doi:10.3390/nu13051525

Cited by 52 publications

(62 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The cow's milk protein is the main source of dietary protein for infants, so cow's milk is a major food allergen in children under 3 years of age. The clinical symptoms of CMPA are not typical and may affect different systems of the body, the severity of clinical symptoms varies and may include vomiting, regurgitation, diarrhea, hematochezia, colic, rash and urticaria, and gastrointestinal bleeding [ 4 , 5 ] and even anaphylactic shock caused by consuming milk protein. Vitamin D is an indispensable nutrient for the growth and development of infants and children, and evidence shows that it is closely related to the occurrence of allergic diseases.…”

Section: Introductionmentioning

confidence: 99%

Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora

Wen-ying¹,

Zhu²,

Chen³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. The aim of this study is to analyze the clinical effect of standardized dietary avoidance therapy on children with cow milk protein allergy (CMPA) and its effect on the intestinal flora. Methods. The clinical data of 200 children with CMPA from our hospital from February 2020 to May 2021 were collected, and they were divided into a study group (n = 100) and a routine group (n = 100) based on different intervention modalities. The routine group received routine treatment, whereas the standardized dietary avoidance therapy was used in the study group. The clinical effects and related intestinal microflora indexes of the two groups were analyzed and compared. Results. There was no significant difference in the incidence of related symptoms between the two groups before intervention ( P > 0.05 ), and the conditions of the two groups were improved after intervention. The incidences of skin (2%), digestive tract (3.00%), and respiratory tract (1.00%) in the study group were significantly lower than those in the routine group (14.00%, 18.00%, and 11.00%) ( P > 0.05 ). The time taken for complete remission of symptoms and milk tolerance months in the study group (41.23 ± 23.68, 13.28 ± 6.17) were significantly shorter than those in the routine group (145.14 ± 66.74, 16.17 ± 8.05) ( P > 0.05 ). The values of height, weight, and head circumference (HC) of children in the study group (79.88 ± 2.18, 11.09 ± 1.34, 47.88 ± 0.63) were higher than those in the routine group (76.21 ± 2.34, 9.81 ± 1.18, 45.98 ± 0.59) ( P > 0.05 ). The levels of Lactobacillus and Enterococcus (9.95 ± 0.89, 11.31 ± 1.05) in the study group were higher than those in the routine group (9.11 ± 0.74, 10.38 ± 0.94), and the levels of yeast-like fungi in the study group (3.08 ± 0.24) were lower than those of the routine group (3.82 ± 0.31) ( P > 0.05 ). Conclusion. The standardized dietary avoidance therapy is remarkable in the treatment of CMPA, in which the children were able to tolerate ordinary milk earlier, and the intestinal flora was significantly improved, thereby promoting the growth and development of children. It therefore merits clinical promotion.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora

Wen-ying¹,

Zhu²,

Chen³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Earlier it was stated that the most common nutritional allergy in the pediatric population is cow's milk protein allergy ( 4 , 24 ). As reported in the multicentric survey–which covered every region in Hungary - conducted by the Hungarian Society of Allergology and Clinical Immunology (Magyar Allergológiai Klinikai Immunológiai Társaság – MAKIT), cow's milk is the second most common food allergen in children.…”

Section: Discussionmentioning

confidence: 99%

Fecal calprotectin levels in pediatric cow's milk protein allergy

et al. 2022

View full text Add to dashboard Cite

IntroductionThe most prevalent food allergy in younger children is cow's milk protein allergy (CMPA), a hypersensitivity reaction to cow's milk protein and its most common clinical manifestation is allergic colitis. The goal of our recent study was to assess somatic symptoms of CMPA and to prospectively observe the effects of a dairy elimination diet using objective parameters and questionnaires.MethodsThe County Hospital in Szekszárd, Hungary, investigated children aged 1 to 18 who had clinical signs that might indicate CMPA. Stool samples were taken and analyzed using a fecal calprotectin (FC) rapid test (Quantum Blue fCAL, Bühlmann Laboratories, Switzerland) at the time of the diagnosis and following 3 months of an elimination diet. At the baseline visit as well as the first and second follow-up, questionnaires were filled out. Patients were divided into two subgroups according to dietary guidelines based on the results of the questionnaires.ResultsA total of 47 patients participated in the study [42.55% female, mean age: 7.36 (SD 4.22) years]. There was no significant difference in FC levels between baseline and after 3-month elimination diet [73.98 (71.12) μg/g and 68.11 (74.4) μg/g, respectively, p = 0.331]. After three months, there was a significant decrease in FC levels among patients who adhered to the strict diet [84.06 (79.48) μg/g and 41.11 (34.24) μg/g, respectively, p = 0.001].ConclusionThe findings of our study suggest that FC can be an objective marker in confirming the diagnosis of CMPA. Significant improvement in clinical symptoms and in FC levels can only be expected after a strictly followed elimination diet.

show abstract

“…It is due to an abnormal immune response to CMP. It should be distinguished from the other adverse effects of cow’s milk, such as lactose intolerance and infection-related disorders[ 4 ]. Both casein and whey (α-lactalbumin and β-lactoglobulin) proteins can cause allergic reactions.…”

Section: Cow’s Milk Protein Allergymentioning

confidence: 99%

Cow’s milk-induced gastrointestinal disorders: From infancy to adulthood

Al‐Biltagi¹,

Saeed²,

Bediwy³

et al. 2022

World J Clin Pediatr

View full text Add to dashboard Cite

Milk is related to many gastrointestinal disorders from the cradle to the grave due to the many milk ingredients that can trigger gastrointestinal discomfort and disorders. Cow’s milk protein allergy (CMPA) is the most common food allergy, especially in infancy and childhood, which may persist into adulthood. There are three main types of CMPA; immunoglobulin E (IgE)-mediated CMPA, non-IgE-mediated CMPA, and mixed type. CMPA appears before the first birthday in almost all cases. Symptoms may start even during the neonatal period and can be severe enough to simulate neonatal sepsis. CMPA (often non-IgE mediated) can present with symptoms of gastroesophageal reflux, eosinophilic esophagitis, hemorrhagic gastritis, food protein-induced protein-losing enteropathy, and food protein-induced enterocolitis syndrome. Most CMPAs are benign and outgrown during childhood. CMPA is not as common in adults as in children, but when present, it is usually severe with a protracted course. Lactose intolerance is a prevalent condition characterized by the development of many symptoms related to the consumption of foods containing lactose. Lactose intolerance has four typical types: Developmental, congenital, primary, and secondary. Lactose intolerance and CMPA may be the underlying pathophysiologic mechanisms for many functional gastrointestinal disorders in children and adults. They are also common in inflammatory bowel diseases. Milk consumption may have preventive or promoter effects on cancer development. Milk may also become a source of microbial infection in humans, causing a wide array of diseases, and may help increase the prevalence of antimicrobial resistance. This editorial summarizes the common milk-related disorders and their symptoms from childhood to adulthood.

show abstract

Cow’s Milk Protein Allergy as a Model of Food Allergies

Cited by 52 publications

References 133 publications

Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora

Clinical Effect of Standardized Dietary Avoidance Therapy on Children with Milk Protein Allergy and Its Effect on Intestinal Flora

Fecal calprotectin levels in pediatric cow's milk protein allergy

Cow’s milk-induced gastrointestinal disorders: From infancy to adulthood

Contact Info

Product

Resources

About