Cowpox in British voles and mice

Bennett, Malcolm J.; Crouch, A.; Begon, Michael; Duffy, Brian; Feore, S.; Gaskell, R. M.; Kelly, D. F.; McCracken, Christina; Vicary, L.; Baxby, Derrick

doi:10.1016/s0021-9975(97)80041-2

Cited by 86 publications

(73 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Great Britain, antibody has been found occasionally in house mice but the highest seroprevalence is in bank voles, wood mice, and field voles, and these species are believed to be the reservoir hosts [6]. Cowpox does not cause obvious clinical signs or increase mortalities in voles or mice in the laboratory [3], experimental studies have demonstrated that cowpox can affect fecundity by delaying the onset of reproduction [15]. Further, it is thought that the CPXV infection, due to many reasons, might have greater impact on survival in field conditions [37] which might further help in establishment of CPXV infection in these wild rodents.…”

Section: Establishment Of Vlvs In Naturementioning

confidence: 99%

Emergence and Reemergence of Vaccinia-Like Viruses: Global Scenario and Perspectives

et al. 2012

View full text Add to dashboard Cite

Section: Establishment Of Vlvs In Naturementioning

confidence: 99%

Emergence and Reemergence of Vaccinia-Like Viruses: Global Scenario and Perspectives

et al. 2012

View full text Add to dashboard Cite

“…Wild rodents are considered the main reservoir hosts [5], although human transmission often occurs from companion animals such as rats and via intermediate domestic pets such as cats [40]. In wild rodents, the highest seroprevalence has been recorded in bank voles, wood mice (Apodemus sylvaticus), and field voles (Microtus agrestis) [2,7,18,12]. Human OPV infection is rare and usually produces a localized lesion on the fingers, hands, or face [33].…”

Section: Introductionmentioning

confidence: 99%

Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

Fevola

Forbes

Mäkelä

et al. 2016

Journal of Clinical Virology

View full text Add to dashboard Cite

a b s t r a c tBackground: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. Objective: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity. Study design: We evaluated seroprevalence of and seroconversions to LCMV, LV and OPV in 116 patients hospitalized for NE. Clinical and laboratory variables were closely monitored during hospital care. Results: A total of five LCMV, 15 LV, and one OPV seroconversions occurred. NE patients with LCMV seroconversions were younger, and had lower plasma creatinine concentrations and platelet counts than patients without LCMV seroconversions. No differences occurred in clinical or laboratory findings between patients with and without seroconversions to LV and OPV. We report, for the first time, LCMV seroprevalence in Finland, with 8.5% of NE patients seropositive for this virus. Seroprevalences for LV and OPV were 47.8% and 32.4%, respectively. Conclusion: Cases with LCMV seroconversions were statistically younger, had milder acute kidney injury and more severe thrombocytopenia than patients without LCMV. However, the low number of seroconversion cases precludes firm conclusions. Concurrent LV or OPV infections do not appear to influence clinical picture for NE patients.

show abstract

“…Originally, cows were wrongly presumed to be CPXV reservoirs. Wild rodents are now considered to be the true reservoirs; cows, cats, zoo animals, and humans are only incidental hosts (1). Human CPXV infections are rare and usually cause localized skin lesions.…”

mentioning

confidence: 99%