COXSACKIE-B-VIRUS-SPECIFIC IgM RESPONSES IN CHILDREN WITH INSULIN-DEPENDENT (JUVENILE-ONSET; TYPE I) DIABETES MELLITUS

King, MaryL; Bidwell, D. E.; Shaikh, Aneena; Voller, A.; Banatvala, J. E.

doi:10.1016/s0140-6736(83)92353-x

Cited by 243 publications

(96 citation statements)

References 10 publications

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“…Detection of CBV specific IgM in such patients could infer recent infection or perhaps persisting viral antigen. Several workers h ve spent much time and effort in the development of a CBV specific IgM assay using the modern virological techniques of ELISA or MACRIA (Dorries & Ter Meulen, 1983;King et al 1983;Morgan-Capner & McSorley, 1983). All have detected non-specific cross-reactions, some not only within the CBV group but also with other enteroviruses and hepatitis A virus.…”

Section: Discussionmentioning

confidence: 99%

A study of Coxsackie B virus infections, 1972–1983

Bell

McCartney

1984

J. Hyg.

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SUMMARYThe results of a twelve-year study of Coxsackie B virus (CBV) infections in patients with a variety of acute and chronic illnesses are reported. CBVs were isolated from only 123 patients most of whom were children with respiratory illness. Virus diagnosis in adults was based mainly on the detection of significant rising or static high neutralizing antibody titres. Between 1972 and 1979 most investigations centred on patients with suspected viral heart disease, 12 % of whom were found to have diagnostically significant CBV titres. In studies on patients with definite myo-pericarditis the number positive increased to 3300. In 1980 clinical interest switched to the possible role of CBV in myalgic encephalomyelitis (ME), an illness of diverse symptomatology. Investigation of suspected cases of ME in 1983 showed that 160 were serologically positive compared to 40 ofnormal adults in the West of Scotland. In patients with well-documented ME this figure rose to 41 0.The demand by clinicians for CBV neutralizing antibody tests has increased over the past twelve years and continues to escalate annually, especially in patients with chronic relapsing illness.

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Section: Discussionmentioning

confidence: 99%

A study of Coxsackie B virus infections, 1972–1983

Bell

McCartney

1984

J. Hyg.

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“…Recently developed IgM specific assays (MACRIA) (Burkhardt, Reigel & Schilt, 1983;El-Hagrassy, Banatvala & Coltart, 1980;Morgan-Capner & McSorley, 1983;Pattison, 1983) for the diagnosis of enterovirus infections and other serological test systems such as complement-fixation (Bussel et al 1962;Halonen, Rosen & Huebner, 1959;Kraft & Melnick, 1952;Schmidt, Dennis & Lennette, 1962), haemagglutination-inhibition (Bussel et al 1962), immunodiffusion (Schmidt, Magoffin & Lennette, 1973), counterimmunoelectrophoresis (Minor et al 1979) or solid-phase immunoassays (Katze & Crowell, 1980a, b;King et al 1983) showed cross-reactivities of IgM antibodies to heterologous viruses. Apparently typespecific reactions in a 'reverse IgM RIA' were described by Torfason, Frisk & Diderholm (1984) using purified virions as antigen.…”

Section: Introductionmentioning

confidence: 99%

Cross-reactions of immunoglobulin M and G antibodies with enterovirus-specific viral structural proteins

Reigel

Burkhardt

Schilt

1985

J. Hyg.

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SUMMARYWe analysed the reactivity ofenterovirus-specific human IgM and IgG antibodies with the structural proteins ofdifferent enteroviruses by the immunoblot technique. In general, all immunoglobulin G antibodies of the tested sera reacted with capsid polypeptide VP 1 of the viruses tested (echoviruses 9 and 11, coxsackievirus B3 and poliovirus 2). In contrast, enterovirus specific immunoglobulin M antibodies of adults reacted with capsid polypeptides VP 1, VP 2, and/or VP 3 of the viruses mentioned above. The reactions with VP 2 and/or VP 3 were often stronger than with VP 1. lgM antibodies from sera of newborns infected by echovirus 11 reacted with VP 1 and VP 2/3 of echovirus 11 and also with VP 2 and VP 3 of poliovirus 2. Preabsorption experiments indicate that cross-reactive IgG antibodies react with epitopes of VP 1 not present on the surface of intact virus particles. The results from the immunoblot technique were compared to data from microneutralization tests and M-antibody capture radioimmunoassays.

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“…Although the difference in prevalence between ICA positive and negative individuals was not statistically significant, a study of larger numbers would be required to exclude such an association. A number of serological studies have found a higher prevalence of coxsackie B virus-specific IgM responses in patients at Type 1 diabetes onset compared with control subjects [5,8,9,22] while others have not [6][7]. In one study, the prevalence of IgM among Type i diabetic patients showed considerable geographic and temporal variation, ranging from 0-76 % [9].…”

Section: Discussionmentioning

confidence: 99%

No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7?19 years

et al. 1991

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Summary. Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7-19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for islet cell antibodies. Anti-coxsackie B1-5 IgM responses were detected in 14 of 44 (32 %) of the islet cell antibody-positive subjects and in 7 of 44 (16 % ) control subjects. This difference did not reach the level of statistical significance. None of the islet cell antibody-positive subjects had specific IgM antibodies to mumps, rubella, or cytomegalovirus. There was also no increase in the prevalence or the mean titres of anti-mumps-IgG or IgA and anti-cytomegalovirus-IgG in islet cell antibody-positive subjects compared to control subjects. These results do not suggest any association between islet cell antibodies, and possibly insulitis, with recent mumps, rubella or cytomegalovirus infection. Further studies are required to clarify the relationship between islet cell antibodies and coxsackie B virus infections.

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COXSACKIE-B-VIRUS-SPECIFIC IgM RESPONSES IN CHILDREN WITH INSULIN-DEPENDENT (JUVENILE-ONSET; TYPE I) DIABETES MELLITUS

Cited by 243 publications

References 10 publications

A study of Coxsackie B virus infections, 1972–1983

A study of Coxsackie B virus infections, 1972–1983

Cross-reactions of immunoglobulin M and G antibodies with enterovirus-specific viral structural proteins

No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7?19 years

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