Coxsackievirus B5 and the Relationship to Swine Vesicular Disease Virus

Knowles, Nick J.; McCauley, John W.

doi:10.1007/978-3-642-60687-8_7

Cited by 19 publications

(10 citation statements)

References 36 publications

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“…SVDV is a porcine variant of the human pathogen coxsackievirus B5 (CVB5) (7,20,47,23,30,54). The antigenic and molecular relationships between these two viruses suggest that SVDV is a genetic sublineage of CVB5 that evolved between 1945 and 1965, after the transfer of CVB5 from humans to pigs (55).…”

Section: Swine Vesicular Disease Virus (Svdv) Is a Member Of Thementioning

confidence: 99%

Structure of Swine Vesicular Disease Virus: Mapping of Changes Occurring during Adaptation of Human Coxsackie B5 Virus To Infect Swine

Verdaguer

Jiménez‐Clavero

Fita

et al. 2003

J Virol

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The structure of swine vesicular disease virus (SVDV) was solved and refined at a 3.0-Å resolution by X-ray crystallography to gain information about the role of sequence changes that occurred as this virus evolved from the parental human pathogen coxsackievirus B5 (CVB5). These amino acid substitutions can be clustered in five distinct regions: (i) the antigenic sites, (ii) the hydrophobic pocket of the VP1 ␤-sandwich, (iii) the putative CAR binding site, (iv) the putative heparan sulfate binding site, and (v) the fivefold axis. The VP1 pocket is occupied by a branched pocket factor, apparently different from that present in the closely related virus CVB3 and in other picornaviruses. This finding may be relevant for the design of new antiviral compounds against this site. Density consistent with the presence of ions was observed on the fivefold and threefold axes. The structure also provided an accurate description of the putative receptor binding sites.

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Section: Swine Vesicular Disease Virus (Svdv) Is a Member Of Thementioning

confidence: 99%

Structure of Swine Vesicular Disease Virus: Mapping of Changes Occurring during Adaptation of Human Coxsackie B5 Virus To Infect Swine

Verdaguer

Jiménez‐Clavero

Fita

et al. 2003

J Virol

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“…The virion capsid consists of a non-enveloped protein shell of 60 protomers, each of which is made up of one copy of each of the four structural proteins VP1, VP2, VP3 and VP4, forming an icosahedral shell of diameter 25-30 µm and symmetry T = 1, which encloses the viral genome, a single molecule of RNA(+) of 7400 nucleotides (Inoue et al, 1989). SVDV is closely related to human coxsackievirus B5 (CV-B5), with which it has 75-85% nucleotide sequence homology (Knowles and McCauley, 1997). The introduction of SVDV into pigs by transmission of CV-B5 from man was first suggested in 1973 (Brown et al, 1973;Graves, 1973).…”

Section: General Features Of the Virus And The Diseasementioning

confidence: 99%

Swine vesicular disease virus. Pathology of the disease and molecular characteristics of the virion

Escribano-Romero

Jiménez‐Clavero

Ley

2000

Anim. Health. Res. Rev.

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Swine vesicular disease is a highly contagious disease of pigs that is caused by an enterovirus of the family Picornaviridae. The virus is a relatively recent derivative of the human coxsackievirus B5, with which it has high molecular and antigenic homology. The disease is not severe, and affected animals usually show moderate general weakening and slight weight loss that is recovered in few days, as well as vesicular lesions in the mucosa of the mouth and nose and in the interdigital spaces of the feet. However, the similarity of these lesions to those caused by foot-and-mouth disease virus has led to the inclusion of this virus in list A of the Office International des Epizooties. The disease has been eradicated in the European Union except in Italy, where it is considered endemic in the south. Nevertheless, as occasional outbreaks still appear and must be eliminated rapidly, European countries are on the alert and farms are monitored routinely for the presence of the virus. This circumstance has led to a considerable effort to study the pathology of the disease and the molecular biology and antigenicity of the virus, and to the development of optimized methods for the diagnosis of the infection.

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“…In the VP1 tree, the closest CB virus to the SVDV clade is a CV-B5 isolate ; in the 3BC tree, it is an echovirus. A comparison of the complete genomes of SVDV, CV-B5 and echoviruses revealed that the close similarity between the 3BC coding region of echoviruses and SVDV is not representative of the rest of the genome (Knowles & McCauley, 1997). While EV-9 is only 11 % divergent from SVDV in 3BC, they are 50 % divergent in VP1.…”

Section: Monophyly Of Svdvmentioning

confidence: 99%

Molecular evolution of swine vesicular disease virus.

Zhang

Haydon

Knowles

et al. 1999

Journal of General Virology

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Phylogenetic analysis was used to examine the evolutionary relationships within a group of coxsackie B viruses that contained representatives of the major serotypes of this group and 45 isolates of swine vesicular disease virus (SVDV) from Asia and Europe. Separate analyses of sequence data from two regions of the viral genomes encoding the VP1 and 3BC genes both revealed that the SVDV belonged to a single monophyletic group which could be clearly distinguished from all other sampled coxsackieviruses. Regression analysis revealed that within the SVDV clade at least 80 % of the synonymous variation in evolutionary divergence between isolates was explained by time, indicating the existence of an approximate molecular clock. Calibration of this clock according to synonymous substitutions per year indicated the date of occurrence of a common ancestor for the SVDV clade to be between 1945 and 1965.

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Coxsackievirus B5 and the Relationship to Swine Vesicular Disease Virus

Cited by 19 publications

References 36 publications

Structure of Swine Vesicular Disease Virus: Mapping of Changes Occurring during Adaptation of Human Coxsackie B5 Virus To Infect Swine

Structure of Swine Vesicular Disease Virus: Mapping of Changes Occurring during Adaptation of Human Coxsackie B5 Virus To Infect Swine

Swine vesicular disease virus. Pathology of the disease and molecular characteristics of the virion

Molecular evolution of swine vesicular disease virus.

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