2016
DOI: 10.4238/gmr.15027752
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CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription

Abstract: ABSTRACT. The dehydrogenase/reductase (SDR family) member 4 (DHRS4) gene is copied during mammalian evolution; therefore, while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively. In this study, we explored the possible regulatory mechanism of the DHRS4 gene cluster in mammalian evolution by analyzing the promoter sequence, methylation of CpG islands, and RNA expression… Show more

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Cited by 5 publications
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“…The encoded protein may be an NADPH dependent retinol oxidoreductase. Genomic loss of DHRS4L2 may lead to low expression and has been demonstrated to be associated with risk of diseases (56,57). The DHRS4L2 gene has not yet been reported to be involved in cancer and could be considered a novel candidate gene for TNBC.…”
Section: Discussionmentioning
confidence: 99%
“…The encoded protein may be an NADPH dependent retinol oxidoreductase. Genomic loss of DHRS4L2 may lead to low expression and has been demonstrated to be associated with risk of diseases (56,57). The DHRS4L2 gene has not yet been reported to be involved in cancer and could be considered a novel candidate gene for TNBC.…”
Section: Discussionmentioning
confidence: 99%