2018
DOI: 10.1016/j.humimm.2018.01.003
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Epigenetics and pathogenesis of systemic sclerosis; the ins and outs

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Cited by 30 publications
(22 citation statements)
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“…The distinct anatomical location and proposed role of environmental factors such as excessive alcohol consumption (13), heavy manual labor, and exposure to vibrations (14) suggest epigenetic regulation is likely to be important in the pathogenesis of the disease. Epigenetic mechanisms have been shown to be crucial mediators of fibrotic gene expression in a wide range of fibrotic disorders (15), including cardiac fibrosis (16), liver fibrosis (17), and systemic sclerosis (18), and probably account for the persistence of myofibroblasts in disease (19).…”
mentioning
confidence: 99%
“…The distinct anatomical location and proposed role of environmental factors such as excessive alcohol consumption (13), heavy manual labor, and exposure to vibrations (14) suggest epigenetic regulation is likely to be important in the pathogenesis of the disease. Epigenetic mechanisms have been shown to be crucial mediators of fibrotic gene expression in a wide range of fibrotic disorders (15), including cardiac fibrosis (16), liver fibrosis (17), and systemic sclerosis (18), and probably account for the persistence of myofibroblasts in disease (19).…”
mentioning
confidence: 99%
“…Accumulating evidence has shown that many miRNAs are also critically involved in the pathogenesis of human tissue fibrosis of in several organs [40]. In the development of fibrosis in SSc, the existence of a pro-fibrosis or anti-fibrosis role has been recognized for selected microRNAs that regulate the well-known pro-fibrotic factor, TGF-β, or directly target the predicted fibrotic genes [41].…”
Section: Discussionmentioning
confidence: 99%
“…Epigenetic changes are heritable alterations of the human genome affecting the gene expression without involving changes of the underlying DNA sequences. As the pathogenesis of SSc is thought to be influenced by environmental factors affecting human genome, these stimuli have been considered to be responsible for epigenetic regulatory complex changes which can manifest in alterations in disease outcomes (Aslani et al, 2018 ). RNA interference via microRNAs is considered to be one of the potential mechanisms to initiate and maintain epigenetic changes.…”
Section: Micrornasmentioning
confidence: 99%