CPT, the main test method of skin neuronal sensitivity

Li, Shuyuan; Wang, Xuemin; Gao, Yanrui; Chen, Shuangyu; Li, Xiaoping; Wang, Haijun; Dong, Yaqi

doi:10.3109/15569527.2014.950379

Cited by 7 publications

(11 citation statements)

References 9 publications

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“…The positive-group had lower CPT value than the negative-group at 5 and 250 Hz. The results were consistent with previous studies (6,20,25). And after the CAT, there was significant increase in the CPT value at 5 and 250 Hz which was mediated by unmyelinated C fibre and small A delta fibre.…”

Section: Discussionsupporting

confidence: 94%

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The evaluation of neural and vascular hyper‐reactivity for sensitive skin

Sun

Wang

Zhang

et al. 2016

Skin Research and Technology

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The sensitive subjects were prone to be stimulated by capsaicin to trigger neural and vascular hyper-reactivity. The genetic variation of TRPV1 and the unpleasant sensation demonstrate that TRPV1 play an important role in the pathogenesis of sensitive skin. Our study supports that sensory irritation inhibitors and anti-inflammatory compounds should be considered to be added in cosmetics to reduce the heighted neural and vascular reaction of sensitive skin.

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Section: Discussionsupporting

confidence: 94%

“…Here, we focus on its characteristic of heighted neural and vascular reaction. Previous studies found that CPT was negatively correlated with TEWL (20,21). The impaired barrier function of skin may cause the exposure of immune system cells and sensitive nerves, leading to discomfort response to otherwise harmless stimuli (22).…”

Section: Discussionmentioning

confidence: 99%

The evaluation of neural and vascular hyper‐reactivity for sensitive skin

Sun

Wang

Zhang

et al. 2016

Skin Research and Technology

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“…Since damage to small cutaneous Aδ and C nerve fibres, especially unmyelinated C-fibres (6), has been described in sensitive skin (5), we expected a significant decrease in the CPT at 5 Hz in sensitive skin compared with non-sensitive skin. This has been described in several studies (13,25,27,28). In some reports, CPT was also reduced at 250 Hz (13,27,28).…”

Section: Discussionsupporting

confidence: 71%

Burden of Sensitive Skin (BoSS) Questionnaire and Current Perception Threshold: Use as Diagnostic Tools for Sensitive Skin Syndrome

Polena¹,

Chavagnac‐Bonneville²,

Miséry³

et al. 2021

Acta Derm Venereol

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The assessment of sensitive skin syndrome, characterized by subjective unpleasant sensations, remains a challenge, since there is no international consensus on the best diagnostic tools. This study evaluated the combination of the Burden of Sensitive Skin (BoSS) questionnaire and the current perception threshold as diagnostic tools for sensitive skin syndrome, and the relationship between BoSS and the subjects’ smoking status, phototype and skin type. A total of 100 women completed the BoSS questionnaire, and current perception threshold was measured on the face. The BoSS score was significantly higher in the self-reported sensitive skin group compared with the non-sensitive skin group (25.61 vs 14.05; p < 0.001), and in non-smokers vs smokers (23.00 vs 18.37; p < 0.05). In addition, the current perception threshold values were similar between the sensitive and non-sensitive groups. These results suggest that BoSS is a better diagnostic tool for sensitive skin syndrome than the current perception threshold, and that smokers less frequently have sensitive skin than do non-smokers.

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“…These subjects may display normal barrier, which could result in LAST negative. It has also been postulated that DMSO is suitable for assessing cutaneous vascular reactions , whereas LAST is more sensitive to assess cutaneous neurosensivity . Additionally, some subjects with sensitive skin display positive response only to either capsaicin or lactic acid .…”

Section: Discussionmentioning

confidence: 99%

Association between lactic acid sting test scores, self‐assessed sensitive skin scores and biophysical properties in Chinese females

Ding

Man

et al. 2019

Intern J of Cosmetic Sci

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BackgroundLactic acid sting test (LAST) is a classical method to identify sensitive skin. However, some subjects with self‐perceived sensitive skin are negative for LAST.ObjectiveTo determine whether LAST scores are associated with specific phenotype of sensitive skin.MethodsA total of 292 subjects with self‐perceived sensitive skin were enrolled in this study. The Sensitive Scale was used to evaluate the severity of burning, stinging, itching, tautness, erythema and scaling based on 0–10 scale scores. In addition to the assessment of LAST scores, epidermal biophysical properties were measured using an MPA system.ResultsThe Sensitive Scale scores of stinging, itching, tautness and scaling were significantly different between the LAST‐positive and ‐negative groups. However, burning and erythema scores did not differ between the LAST‐positive and ‐negative groups. LAST scores were positively correlated with the Sensitive Scale scores for stinging, itching, tautness and scaling, but not for burning and erythema scores. Moreover, LAST scores negatively correlated with stratum corneum hydration, but positively with transepidermal water loss (TEWL) rates.ConclusionsLactic acid sting test scores positively correlated with TEWL rates. LAST scores could be used to identify subjects with sensitive skin characterized mainly by stinging and itching, but not those mainly by burning and erythema.

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CPT, the main test method of skin neuronal sensitivity

Abstract: Different degrees of skin susceptibility can be reflected by BT. CPT can be useful for the quantitative evaluation of skin neuronal sensitivity.

Cited by 7 publications

References 9 publications

The evaluation of neural and vascular hyper‐reactivity for sensitive skin

The evaluation of neural and vascular hyper‐reactivity for sensitive skin

Burden of Sensitive Skin (BoSS) Questionnaire and Current Perception Threshold: Use as Diagnostic Tools for Sensitive Skin Syndrome

Association between lactic acid sting test scores, self‐assessed sensitive skin scores and biophysical properties in Chinese females

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