Cracking the code: Deciphering the role of the tumor microenvironment in osteosarcoma metastasis

Jin, Jiamin; Cong, Jiacheng; Lei, Shangbo; Zhang, Qiujin; Zhong, Xinyi; Su, Yingying; Lu, Ming; He, Jingliang; Wang, Liyan; Zhu, Nianyong; Yang, Jinfeng

doi:10.1016/j.intimp.2023.110422

Cited by 5 publications

(3 citation statements)

References 151 publications

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“…Furthermore, RAS/RAF/MEK/ERK signaling in OS was significantly associated with immune infiltration and tumor microenvironment (TME) [ 149 ]. OS microenvironment is undeniably essential for growth and dissemination [ 150 , 151 ]. Beside immune evasion, stromal and other tumor-associated cells influence OS by secreting growth factors, cytokines, and exosomal and non-exosomal miRNAs that lead to metabolic reprogramming, extracellular matrix remodeling, neovascularization, drug resistance, and maintenance of the cancer stem cells phenotype [ 69 , 152 ].…”

Section: Nf-κb Dysregulation and Cancermentioning

confidence: 99%

Amicis Omnia Sunt Communia: NF-κB Inhibition as an Alternative to Overcome Osteosarcoma Heterogeneity

Medeiros,

Guenka,

Bastos

et al. 2024

Pharmaceuticals

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Tumor heterogeneity poses a significant challenge in osteosarcoma (OS) treatment. In this regard, the “omics” era has constantly expanded our understanding of biomarkers and altered signaling pathways (i.e., PI3K/AKT/mTOR, WNT/β-catenin, NOTCH, SHH/GLI, among others) involved in OS pathophysiology. Despite different players and complexities, many commonalities have been described, among which the nuclear factor kappa B (NF-κB) stands out. Its altered activation is pervasive in cancer, with pleiotropic action on many disease-relevant traits. Thus, in the scope of this article, we highlight the evidence of NF-κB dysregulation in OS and its integration with other cancer-related pathways while we summarize the repertoire of compounds that have been described to interfere with its action. In silico strategies were used to demonstrate that NF-κB is closely coordinated with other commonly dysregulated signaling pathways not only by functionally interacting with several of their members but also by actively participating in the regulation of their transcription. While existing inhibitors lack selectivity or act indirectly, the therapeutic potential of targeting NF-κB is indisputable, first for its multifunctionality on most cancer hallmarks, and secondly, because, as a common downstream effector of the many dysregulated pathways influencing OS aggressiveness, it turns complex regulatory networks into a simpler picture underneath molecular heterogeneity.

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Section: Nf-κb Dysregulation and Cancermentioning

confidence: 99%

Amicis Omnia Sunt Communia: NF-κB Inhibition as an Alternative to Overcome Osteosarcoma Heterogeneity

Medeiros,

Guenka,

Bastos

et al. 2024

Pharmaceuticals

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“…Patients with metastasis at diagnosis or recurrence was only a 20% 5-year survival rate ( Meazza and Scanagatta, 2016 ). Significantly, recently conducted studies have demonstrated a robust correlation between modifications in the cellular microenvironment and the occurrence of OS metastasis ( Jin J. et al, 2023a ).…”

Section: Introductionmentioning

confidence: 99%

Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis

Zhou,

Lan,

Liu

et al. 2024

Front. Pharmacol.

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Osteosarcoma (OS) is a malignant tumor originating from mesenchymal tissue. Pulmonary metastasis is usually present upon initial diagnosis, and metastasis is the primary factor affecting the poor prognosis of patients with OS. Current research shows that the ability to regulate the cellular microenvironment is essential for preventing the distant metastasis of OS, and anoxic microenvironments are important features of solid tumors. During hypoxia, hypoxia-inducible factor-1α (HIF-1α) expression levels and stability increase. Increased HIF-1α promotes tumor vascular remodeling, epithelial-mesenchymal transformation (EMT), and OS cells invasiveness; this leads to distant metastasis of OS cells. HIF-1α plays an essential role in the mechanisms of OS metastasis. In order to develop precise prognostic indicators and potential therapeutic targets for OS treatment, this review examines the molecular mechanisms of HIF-1α in the distant metastasis of OS cells; the signal transduction pathways mediated by HIF-1α are also discussed.

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“…STS is rare, comprising approximately 1% of adult solid tumors. Nevertheless, osteosarcoma (OS) remains the predominant initial malignant bone neoplasm in children and teenagers, constituting around half of all pediatric tumors, with Ewing's sarcoma (ES) following closely (3)(4)(5). Sarcoma, as a malignant tumor, typically presents with a 5-year survival rate of around 65% and is commonly detected in later stages (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

A bibliometric analysis based on hotspots and frontier trends of positron emission tomography/computed tomography utility in bone and soft tissue sarcoma

Xiang,

Zhang,

Tan

et al. 2024

Front. Oncol.

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PurposeThis study aimed to analyze articles on the diagnosis and treatment of bone and soft tissue sarcoma using positron emission tomography (PET)/computed tomography (CT) published in the last 13 years. The objective was to conduct a bibliometric analysis and identify the research hotspots and emerging trends.MethodsWeb of Science was used to search for articles on PET/CT diagnosis and treatment of bone and soft tissue sarcoma published from January 2010 to June 2023. CiteSpace was utilized to import data for bibliometric analysis.ResultsIn total, 425 relevant publications were identified. Publications have maintained a relatively stable growth rate for the past 13 years. The USA has the highest number of published articles (139) and the highest centrality (0.35). The UDICE-French Research Universities group is the most influential institution. BYUN BH is a prominent contributor to this field. The Journal of Clinical Oncology has the highest impact factor in the field.ConclusionThe clinical application of PET/CT is currently a research hotspot. Upcoming areas of study concentrate on the merging of PET/CT with advanced machine learning and/or alternative imaging methods, novel imaging substances, and the fusion of diagnosis and therapy. The use of PET/CT has progressively become a crucial element in the identification and management of sarcomas. To confirm its efficacy, there is a need for extensive, multicenter, prospective studies.

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Cracking the code: Deciphering the role of the tumor microenvironment in osteosarcoma metastasis

Cited by 5 publications

References 151 publications

Amicis Omnia Sunt Communia: NF-κB Inhibition as an Alternative to Overcome Osteosarcoma Heterogeneity

Amicis Omnia Sunt Communia: NF-κB Inhibition as an Alternative to Overcome Osteosarcoma Heterogeneity

Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis

A bibliometric analysis based on hotspots and frontier trends of positron emission tomography/computed tomography utility in bone and soft tissue sarcoma

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