Cranberry juice improved antioxidant status without affecting bone quality in orchidectomized male rats

Villarreal, Arnulfo; Stoecker, Barbara J.; García, Claudia; Garcia, Kristi; Rios, Ryan; Gonzales, Cheri; Mandadi, Kranthi K.; Faraji, Bahram; Patil, Bhimanagouda S.; Deyhim, Farzad

doi:10.1016/j.phymed.2007.04.004

Cited by 19 publications

(10 citation statements)

References 20 publications

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“…Villarreal et al (2007) also reported that plasma antioxidant status was increased and red blood cell was protected against hemolysis by drinking cranberry juice in rats. In this study, plasma total antioxidant capacity measure by FRAP tended to be increased by cranberry powder treatment, although there was no significant difference.…”

Section: Discussionmentioning

confidence: 96%

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Effects of cranberry powder on serum lipid profiles and biomarkers of oxidative stress in rats fed an atherogenic diet

et al. 2008

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This study investigated that the antioxidative effect of freeze-dried cranberry powder against protein and lipid oxidation and ameliorative effect of serum lipid profile in rat fed atherogenic diet. Six weeks old male Sprague-Dawley rats were divided into the following four groups: normal diet group with 5% corn oil (control), atherogenic diet group with 5% corn oil, 10% lard, 1% cholesterol, and 0.5% sodium cholate (HFC), atherogenic plus 2% cranberry powder diet group (HFC + C2), and atherogenic plus 5% cranberry powder diet group (HFC + C5), and respective diet and water were fed daily for 6 weeks. After the experimental period, the serum lipid profile, such as total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride, ferric reducing ability of plasma (FRAP), plasma phenolics content, superoxide dismutase (SOD) activity, serum protein carbonyl and thiobarbituric acid reactive substances (TBARS) levels were examined. Total phenolic compound and total flavonoid levels in freeze-dried cranberry powder were 9.94 mg/g and 8.12 mg/g, respectively. Serum total cholesterol and LDL-cholesterol levels were not significantly different for cranberry powder treatment, but serum HDL-cholesterol level was significantly increased in HFC + C5 group compared with HFC group. Plasma FRAP value tended to be increased by cranberry powder treatment though there was no significant difference. Plasma total phenol concentrations and SOD activities were not significantly different among all groups. Serum protein carbonyl and TBARS levels were significantly decreased in HFC + C5 group compared with HFC group. Overall results suggested that freeze-dried cranberry powder might have the serum lipid improving effect, as well as antioxidative effect demonstrated by its protective effect against protein and lipid oxidation.

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Section: Discussionmentioning

confidence: 96%

“…In addition, cranberry was known to have antioxidant properties as shown in plasma antioxidant status, protection of RBC against hemolysis and a cellular antioxidant activity (Villarreal et al, 2007; Wolfe & Liu, 2007). …”

Section: Introductionmentioning

confidence: 99%

Effects of cranberry powder on serum lipid profiles and biomarkers of oxidative stress in rats fed an atherogenic diet

et al. 2008

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“…Various studies have reported that berry intake can increase antioxidant status and reduce the level of inflammatory biomarkers in vivo . Cranberry juice significantly increased plasma antioxidant capacity, red blood cell (RBC) oxidative resistance, and SOD in OVX rats [ 50 ] . Bilberry was shown to decrease MDA levels, and decrease IL-6 and IL-15 (inflammatory mediators) in oxidative stress induced states [ 51 , 52 ].…”

Section: Polyphenol Intake and Bone Healthmentioning

confidence: 99%

Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies

Hubert

Lee

et al. 2014

Antioxidants

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Bone loss during aging has become an increasing public health concern as average life expectancy has increased. One of the most prevalent forms of age-related bone disease today is osteoporosis in which the body slows down bone formation and existing bone is increasingly being resorbed by the body to maintain the calcium balance. Some causes of this bone loss can be attributed to dysregulation of osteoblast and osteoclast activity mediated by increased oxidative stress through the aging process. Due to certain serious adverse effects of the currently available therapeutic agents that limit their efficacy, complementary and alternative medicine (CAM) has garnered interest as a natural means for the prevention of this debilitating disease. Natural antioxidant supplementation, a type of CAM, has been researched to aid in reducing bone loss caused by oxidative stress. Naturally occurring polyphenols, such as anthocyanins rich in berries, are known to have anti-oxidative properties. Several studies have been reviewed to determine the impact polyphenol intake—particularly that of berries—has on bone health. Studies reveal a positive association of high berry intake and higher bone mass, implicating berries as possible inexpensive alternatives in reducing the risk of age related bone loss.

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“…Moreover, hesperidin, one of the main flavonoids present in oranges, was reported to improve bone qual ity in rodents and prevented ovariectomy induced bone loss in mice and rats [29,30]. However, such a benefit was not observed in orchidectomized male rats fed cranberry juice [32]. However, such a benefit was not observed in orchidectomized male rats fed cranberry juice [32].…”

Section: Animal or In Vitro Studiesmentioning

confidence: 99%

Fruit, Vegetables, and Bone Health

Chen

2010

Bioactive Foods in Promoting Health

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Cranberry juice improved antioxidant status without affecting bone quality in orchidectomized male rats

Cited by 19 publications

References 20 publications

Effects of cranberry powder on serum lipid profiles and biomarkers of oxidative stress in rats fed an atherogenic diet

Effects of cranberry powder on serum lipid profiles and biomarkers of oxidative stress in rats fed an atherogenic diet

Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies

Fruit, Vegetables, and Bone Health

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