Dietary Polyphenols, Berries, and Age-Related Bone Loss:  A Review Based on Human, Animal, and Cell Studies

Hubert, Patrice; Lee, Sang Gil; Lee, Sun-Kyeong; Chun, Ock K.

doi:10.3390/antiox3010144

Cited by 54 publications

(60 citation statements)

References 74 publications

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“…These compounds have been reported to be present in various organs of rats, including target organs for Cd, such as kidneys and liver [37]; however, their penetration into the bone tissue has not been investigated, but it cannot be excluded. The available data indicating that consumption of polyphenols improves bone turnover and BMD in both human [21] and experimental animals [16,23] confirm the possibility of the direct impact of these compounds on bone status.…”

Section: Figmentioning

confidence: 63%

“…Elliott; Rosaceae]. Nowadays, the consumption of aronia berries is widely recommended as one of the most abundant sources of compounds having a beneficial influence on the organism, and the richest source among plant materials of anthocyanins, which are characterized by strong antioxidative properties [13,14,[18][19][20][21]. Data provided by Kowalczyk et al [15] and our recent findings [6,22,23] seem to indicate that the consumption of chokeberries and their products may prevent Cd accumulation in the body and its toxic action.…”

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confidence: 99%

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The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

et al. 2016

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!Recently, we demonstrated in a rat model that consumption of a polyphenol-rich extract obtained from the berries of Aronia melanocarpa could protect from cadmium-induced disorders in bone turnover and changes in bone mineral status. The aim of this study was to investigate whether the osteoprotective effect of this extract is mediated by the oxidative defense system. Enzymatic and nonenzymatic antioxidants, total antioxidative and oxidative status, hydrogen peroxide, and markers of oxidative protein, lipid, and DNA damage were determined in bone tissue at the distal femoral epiphysis of female Wistar rats receiving 0.1 % aqueous A. melanocarpa extract (prepared from the lyophilized commercial extract containing 65.74 % of polyphenols) as the only drinking fluid and/or cadmium in the diet (1 and 5 mg/kg) for 3, 10, 17, and 24 months. The total oxidative and antioxidative status of the serum was also evaluated. The administration of A. melanocarpa extract provided significant protection from cadmium-induced oxidative stress in the bone and serum, and from lipid peroxidation and oxidative damage to the protein and DNA in the bone tissue. Numerous correlations were noted between indices of the oxidative/antioxidative bone status and markers of bone metabolism previously assayed in the animals receiving A. melanocarpa extract. The results allow the conclusion that the ability of A. melanocarpa extract to mediate the oxidative defense system and prevent oxidative modifications of protein, lipid, and DNA in the bone tissue plays an important role in its osteoprotective action under exposure to cadmium. The findings provide further evidence supporting our suggestion that chokeberry may be a promising natural agent for protection against the toxic action of cadmium in women chronically exposed to this metal. Abbreviations

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Section: Figmentioning

confidence: 63%

mentioning

confidence: 99%

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

et al. 2016

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“…Berries contain abundant anthocyanins and have been recognized as valuable sources of natural medicines and dietary supplements (29,32). Various studies have demonstrated that berry intake may increase antioxidant status and reduce inflammatory biomarker levels in vivo (29). Based on these findings, our group hypothesized that berry consumption may be helpful in alleviating bone resorption and bone density loss following menopause.…”

Section: Introductionmentioning

confidence: 95%

“…Additionally, Welch et al (31) suggested an anti-osteoporotic effect of anthocyanins in a cohort study of twins, in which the differences between the highest and lowest fifths of anthocyanin intake were associated with a 3.4% higher BMD at the spine and a 3.1% higher BMD at the hip. Berries contain abundant anthocyanins and have been recognized as valuable sources of natural medicines and dietary supplements (29,32). Various studies have demonstrated that berry intake may increase antioxidant status and reduce inflammatory biomarker levels in vivo (29).…”

Section: Introductionmentioning

confidence: 99%

“…The positive health effects of foods rich in anthocyanins include CVD prevention and anticancer, anti-inflammatory, antioxidative, anti-obesity, anti-diabetic and neuroprotective activities (29,30). Additionally, Welch et al (31) suggested an anti-osteoporotic effect of anthocyanins in a cohort study of twins, in which the differences between the highest and lowest fifths of anthocyanin intake were associated with a 3.4% higher BMD at the spine and a 3.1% higher BMD at the hip.…”

Section: Introductionmentioning

confidence: 99%

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Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

et al. 2017

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Abstract. Menopause is associated with increased oxidative stress, which serves a role, in part, in the pathogenesis of postmenopausal bone loss. Fruits and vegetables are rich in antioxidative nutrients and phytochemicals. Berries are a natural source of anthocyanins, and their intake may improve bone health. The aim of the present study was to determine the effect of an anthocyanin-rich bilberry extract (VME) on bone metabolism in an ovariectomized (Ovx) rat. Female Sprague-Dawley rats (12 weeks old) were randomly divided into the following four groups: Baseline, Sham, Ovx and Ovx+VME (n=8-12 rats per group). Rats in the Baseline group were sacrificed immediately, while those in the other groups were subjected to either sham operation (Sham) or bilateral Ovx (Ovx and Ovx+VME). Rats in the Ovx+VME group were administered VME daily at a dose of 500 mg/kg body weight. At 8 weeks after surgery, bone mass and bone histomorphometry were evaluated. The femur bone mineral density (BMD) in the Ovx group was significantly lower than that in the Sham group (P<0.01). Supplementation of VME in the Ovx rats did not result in an increase in BMD. Histomorphometric analyses revealed that Ovx resulted in decreased measures of bone volume and trabecular number and increased measures of osteoid volume, mineralizing surface and bone formation rates (all P<0.01), whereas VME had no significant effects on these parameters. The present findings indicate that VME did not alter bone metabolism in Ovx rats, suggesting that consumption of VME may not be helpful in preventing postmenopausal bone loss.

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Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1

et al. 2019

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Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention and/or management of osteoporosis. Osteocytes are the main regulators of bone remodelling. For the first time, we demonstrate here that blueberry juice ( BJ ), obtained from Vaccinium myrtillus , rich in polyphenols, shows antioxidant and antiosteoclastogenic properties in MLO ‐Y4 osteocytes. We report that BJ prevents oxidative stress‐induced apoptosis and reverses the increase in receptor activator of nuclear factor κB ligand and sclerostin expression, crucial factors for osteoclast activation and bone resorption. BJ is also able to prevent oxidative stress‐induced cell cytotoxicity in bone marrow mesenchymal stromal cells ( MSC s), which are considered to be an important tool for cell therapy in bone disorders. No significant difference in preventing these events was observed between BJ and blueberry dry extract containing equal amounts of total soluble polyphenols. We have also shown that blueberry acts as both an antioxidant and an activator of sirtuin type 1, a class III histone deacetylase involved in cell death regulation and considered a molecular target for blocking bone resorption without affecting osteoclast survival. Overall, these novel data obtained in osteocytes and MSC s may help us clarify the mechanisms by which blueberry counteracts oxidative stress‐induced damage in bone remodelling and osteogenesis at the cellular and molecular level. Our findings are consistent with the reported beneficial effects of blueberry on bone tissue reported in animal studies, which suggest that blueberry may be a useful supplement for the prevention and/or management of osteoporosis and osteogenic process.

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Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies

Cited by 54 publications

References 74 publications

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1

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