Aims: This study aimed to detect if there are a correlation between the maxillary sinus measurements ( height and depth) with the cranial and facial structures that probably could estimate a functional matrix rule of the maxillary sinus in the growth of these structure add to estimate the percent of increase from age group to another. Materials and Methods: A digital lateral cephalometric radiographs of 113 males with class I malocclusion from Mosul city were divided into three age groups: 14 patients Preadolescent (6-9 years), 70 patients adolescent (11-15 years) and 29 patients adult (17-42 years) with measurements taken involving the maxillary sinus height and depth, maxillary length, mandibular lengths, anterior facial height(upper and lower parts), posterior facial height (upper and lower part), cranial base dimensions then a correlation have been down between the maxillary sinus height and depth with the related dimensions of the craniofacial complex. Results: The correlation between the MSH and the related craniofacial dimensions in the three age groups showed a significantly positive correlations in nearly all of the measurement specially at adolescences and adults with just two significant positive correlations for MRL and TPFH in preadolescence, on the other hand correlating the MSH with the related measurement in general in single group showed a positive significant correlation for all measurement. While correlating the MSD with the related craniofacial dimensions showed a significantly positive correlation with MBL, TML and Nba in adult. For MBL and TML in preadolescence, but no significant correlation showed in adolescence, with a significant correlation for MSD with nearly all the related craniofacial dimensions in all age group in general. In all measurement the percentage of increase from preadolescence to adolescence more than that from adolescence to adult. Conclusions: we could concluded that in the three age groups the growth of the maxillary sinus probably may influence the related craniofacial structures as a functional matrix role in the growth mechanism.