Cranial computed tomography in the detection of dural, orbital, and skull involvement in metastatic neuroblastoma

Healy, John F.; Bishop, John W.; Rosenkrantz, Harvey

doi:10.1016/0149-936x(81)90069-2

Cited by 14 publications

(7 citation statements)

References 6 publications

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“…Neuroblastomas are metastatic in up to 70% of patients at the time of presentation [126]. Metastatic cranial manifestations most often present as osseous lesions involving the calvaria, orbit, or skull base [127], with neuroblastoma being the commonest metastasis to the skull in this age group [128].…”

Section: Malignant Neoplasiamentioning

confidence: 99%

A systematic approach in the diagnosis of paediatric skull lesions: what radiologists need to know

et al. 2019

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Paediatric skull lesions are commonly identified on imaging. They can be challenging to image, given their location and size, and often require several imaging modalities to narrow down the differential diagnosis. Accurate diagnosis of these lesions is paramount because the clinical therapy can vary tremendously. In this review, we provide a simple and systematic approach to clinical-radiological features of primary skull lesions. We highlight the imaging characteristics and differentiate pathologies based on imaging appearances. We also accentuate the role of cross-sectional imaging in lesion identification and management implications.

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Section: Malignant Neoplasiamentioning

confidence: 99%

A systematic approach in the diagnosis of paediatric skull lesions: what radiologists need to know

et al. 2019

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“…NB is the most frequent malignant metastasis to the skull in children. [5] These calvarial lesions frequently enlarge to produce epidural deposits. Metastatic involvement of the skull has various possible radiographic findings: thickened bone, the "hair-onend" periosteal reaction, lytic defects, and sutural separation.…”

Section: Discussionmentioning

confidence: 99%

“…They are generally asymptomatic or may be revealed by a painful swelling. [2,5] In rare cases, they represent the initial manifestation of an unknown cancer or of a recurrence. [2,4] They can be encountered at any age, with a higher prevalence during the sixth and seventh decades of life.…”

Section: Discussionmentioning

confidence: 99%

Sun-Burst Appearance of Neuroblastoma Metastasis on USC

Mittal¹,

Hazer²,

Kuamr³

et al. 2019

jemds

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Periosteal reaction may be classified as benign or aggressive based on the time course of the initiating process. Benign periosteal reaction is a low-grade chronic irritation which allows time for the formation of normal or near-normal cortex. The cortex will be thick and dense and has a wavy or uniform appearance. Benign periosteal reactions can be seen in callus formation in a fracture or with slowly growing tumours. Aggressive periosteal reaction is a rapid irritation process that does not allow the periosteum time to lay down and consolidate new bone to form normal cortex. The cortex may appear lamellated, amorphous, or sunburst-like. Aggressive periosteal reactions can not only be seen with malignant tumours, but also with more benign processes like infection, eosinophilic granuloma (Langerhans cell histiocytosis), aneurysmal bone cyst, osteoid osteoma, haemophilia, and trauma.

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“…Secondary craniocerebral metastases often manifests as osseous lesions involving base of skull, orbit and calvaria [2]. Metastasis to skull is noted in approximately 25% of cases with neuroblastoma being the most common malignant metastasis to skull in children [3]. The imaging appearance varies from lytic defects, "hair-on-end" periosteal reaction to the separation of sutures.…”

Section: Introductionmentioning

confidence: 99%

“…The imaging appearance varies from lytic defects, "hair-on-end" periosteal reaction to the separation of sutures. The sutural separation seen in neuroblastoma is non-uniform with indistinct margins, contrary to uniform appearance of raised intracranial pressure [3,4]. The presence of primary adrenal neuroblastoma with extensive skeletal metastases particularly to skull, causing proptosis and bone pain has been referred to as 'Hutchinson's syndrome' [5].…”

Section: Introductionmentioning

confidence: 99%

Neuroblastoma: Incidental Craniocerebral Metastasis - A Case Report

Jain

Singlab²

2016

IJMS

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Neuroblastoma has been attributed the term "the great imitator" due to its varied spectrum of presentations. Although neuroblastoma is a common childhood malignancy, which frequently metastasizes, involvement of the Central nervous system is rarely reported in the literature. It commonly metastasizes to the base of the skull and orbits late in the disease. Early detection and aggressive treatment of this complication may allow some patients to live longer than they would have otherwise.

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Cranial computed tomography in the detection of dural, orbital, and skull involvement in metastatic neuroblastoma

Cited by 14 publications

References 6 publications

A systematic approach in the diagnosis of paediatric skull lesions: what radiologists need to know

A systematic approach in the diagnosis of paediatric skull lesions: what radiologists need to know

Sun-Burst Appearance of Neuroblastoma Metastasis on USC

Neuroblastoma: Incidental Craniocerebral Metastasis - A Case Report

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