Cranial Reconstruction Using Bioabsorbable Calcified Triglyceride Bone Cement

Nuzzo, G; Luongo, Marianna; Parlato, C; Moraci, A

doi:10.1097/scs.0b013e3181e20a5b

Cited by 20 publications

(20 citation statements)

References 6 publications

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“…Pilot clinical data suggest that sternal bone healing is accelerated and postoperative recovery is improved [3]; findings have been reproduced by other independent groups [5]. The Kryptonite bone cement has also been utilized in neurosurgical procedures involving the cranium and vertebrae with good results [6, 7]. While the innovation requires substantial further validation, we observed global enthusiasm from both surgeons and patients.…”

Section: Discussionsupporting

confidence: 66%

Adhesive-Enhanced Sternal Closure: Feasibility and Safety of Late Sternal Reentry

Spooner

Mewhort

DiFrancesco

et al. 2017

Case Reports in Surgery

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This clinical case report describes sternal reentry performed years after adhesive-enhanced sternal closure using Kryptonite bone cement. This report provides novel data on the late effects of this innovation. We observed that sternal reentry is feasible and safe. The adhesive did not weaken from biodegradation over a period of several years. There was no evidence of adherence to adjacent soft tissues or other nonbony deep mediastinal structures. Surgeons who receive patients who require redoing cardiac surgery after adhesive-enhanced closure with Kryptonite can be reassured that sternal reentry is safe and feasible.

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Section: Discussionsupporting

confidence: 66%

Adhesive-Enhanced Sternal Closure: Feasibility and Safety of Late Sternal Reentry

Spooner

Mewhort

DiFrancesco

et al. 2017

Case Reports in Surgery

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“…Nevertheless, with the lack of adhesives for bone fracture fixations a clear opportunity exists. The use of cyanoacrylates, bone cements, and other explored suggestions such as isocyanate–polyols chemistry or biomimetic strategies using phosphates, amines, and catechols has proven promising, but has not expanded the area to its full potential, where either bond strength, doubtful biocompatibility, and inadequate adhesive methodology have been the main obstacles. [5c,6c,9] For thiol–ene adhesives, the lack of mechanical rigidity and adhesion to wet surfaces to promote a high bond strength has been challenges to overcome until now.…”

Section: Introductionmentioning

confidence: 99%

High‐Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair

Granskog

García‐Gallego

Kieseritzky

et al. 2018

Adv Funct Materials

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The use of adhesives for fracture fixation can revolutionize the surgical procedures toward more personalized bone repairs. However, there are still no commercially available adhesive solutions mainly due to the lack of biocompatibility, poor adhesive strength, or inadequate fixation protocols. Here, a surgically realizable adhesive system capitalizing on visible light thiol-ene coupling chemistry is presented. The adhesives are carefully designed and formulated from a novel class of chemical constituents influenced by dental resin composites and self-etch primers. Validation of the adhesive strength is conducted on wet bone substrates and accomplished via fiber-reinforced adhesive patch (FRAP) methodology. The results unravel, for the first time, on the promise of a thiol-ene adhesive with an unprecedented shear bond strength of 9.0 MPa and that surpasses, by 55%, the commercially available acrylate dental adhesive system Clearfil SE Bond of 5.8 MPa. Preclinical validation of FRAPs on rat femur fracture models details good adhesion to the bone throughout the healing process, and are found biocompatible not giving rise to any inflammatory response. Remarkably, the FRAPs are found to withstand loads up to 70 N for 1000 cycles on porcine metacarpal fractures outperforming clinically used K-wires and match metal plates and screw implants.

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“…In addition, it has been shown to have bioabsorbable and osteoconductive properties [52,53]. However, wires are still needed in the first few hours to allow the kryptonite to set.…”

Section: Introductionmentioning

confidence: 99%

A Novel Glass Polyalkenoate Cement for Fixation and Stabilisation of the Ribcage, Post Sternotomy Surgery: An ex-Vivo Study

Alhalawani

Curran

Pingguan‐Murphy

et al. 2013

JFB

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This study investigates the use of gallium (Ga) based glass polyalkenoate cements (GPCs) as a possible alternative adhesive in sternal fixation, post sternotomy surgery. The glass series consists of a Control (CaO–ZnO–SiO2), and LGa-1 and LGa-2 which contain Ga at the expense of zinc (Zn) in 0.08 mol% increments. The additions of Ga resulted in increased working time (75 s to 137 s) and setting time (113 to 254 s). Fourier Transform Infrared (FTIR) analysis indicated that this was a direct result of increased unreacted poly(acrylic acid) (PAA) and the reduction of crosslink formation during cement maturation. LGa samples (0.16 wt % Ga) resulted in an altered ion release profile, particularly for 30 days analysis, with maximum Ca2+, Zn2+, Si4+ and Ga3+ ions released into the distilled water. The additions of Ga resulted in increased roughness and decreased contact angles during cement maturation. The presence of Ga has a positive effect on the compressive strength of the samples with strengths increasing over 10 MPa at 7 days analysis compared to the 1 day results. The additions of Ga had relatively no effect on the flexural strength. Tensile testing of bovine sterna proved that the LGa samples (0.16 wt % Ga) are comparable to the Control samples.

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Cranial Reconstruction Using Bioabsorbable Calcified Triglyceride Bone Cement

Cited by 20 publications

References 6 publications

Adhesive-Enhanced Sternal Closure: Feasibility and Safety of Late Sternal Reentry

Adhesive-Enhanced Sternal Closure: Feasibility and Safety of Late Sternal Reentry

High‐Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair

A Novel Glass Polyalkenoate Cement for Fixation and Stabilisation of the Ribcage, Post Sternotomy Surgery: An ex-Vivo Study

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