Craniocerebral Aspergillosis of Sinonasal Origin in Immunocompetent Patients: Clinical Spectrum and Outcome in 25 Cases

Abstract

Craniocerebral aspergillosis in immunocompetent hosts has three patterns of presentation that seem to correlate with clinical outcomes. Intracerebral aspergillosis (Type 1) is associated with the worst clinical outcome. Patients with orbital and cranial base aspergillosis (Type 3) had good recovery. Intracranial extradural aspergillosis (Type 2) remained intermediate on the Glasgow Outcome Scale. Preoperative orally administered itraconazole therapy may improve clinical outcome in patients with intracerebral aspergillosis. Prospective clinical studies are required to make firm clinical therapeutic recommendations.

Comparison of Efficacy of Amphotericin B and Itraconazole in Chronic Invasive Fungal Sinusitis

“…The male to female ratio in our study was 1.36:1. Young and middle age people were affected more in accordance with the other studies [3].…”

“…Slight male preponderance was noted in our study similar to other studies [3]. The male to female ratio in our study was 1.36:1.…”

Local Administration of Amphotericin B Against Aspergilloma in the Prepontine Cistern-Case Report-

“…CNS aspergillosis remains one of the most refractory infections, and usually requires multiple therapeutic strategies, including systemic antifungal agents, surgery, and intrathecal or intraventricular administration of amphotericin B (AmB). 7,8,17,25) Mortality reaches 75-100% despite such intensive treatment. 10,26) However, long-term survivors have been reported on rare occasions.…”

Immunohistochemical Analysis of Leucocyte Subsets in the Sinonasal Mucosa of Cats with Upper Respiratory Tract Aspergillosis

“…The differences in clinical presentation and outcome have been associated with the infecting Aspergillus species, since most cases of SNA are caused by A. fumigatus and SOA is most frequently caused by A. felis (Barrs et al, 2012(Barrs et al, , 2013. It is yet to be fully (Clancy and Nguyen, 1998;Tarrand et al, 2003;Siddiqui et al, 2004;Webb and Vikram, 2010;Gupta et al, 2012). The cats in the present study had histopathological findings most consistent with the granulomatous invasive form of disease (Challa et al, 2010).…”