Craniofacial morphology, dental occlusion, tooth eruption, and dental maturity in boys of short stature with or without growth hormone deficiency

Kjellberg, Heidrun; Beiring, Martin; Wikland, Kerstin Albertsson

doi:10.1034/j.1600-0722.2000.108005359.x

Cited by 74 publications

(81 citation statements)

References 18 publications

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“…The authors explained this fact by a considerable delay in dental age at the beginning of treatment. Kjellberg et al [2], observed in their own studies on a group of short stature boys, that dental age was delayed by about 1 year, which was also confirmed by other authors [3][4][5]. There is also the opinion in the study by Van Erum et al [27] that treatment with GH does not markedly affect the mean value of dental age.…”

Section: Discussionsupporting

confidence: 71%

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Influence of growth hormone therapy on selected dental and skeletal system parameters

Partyka¹,

Chałas²,

Dunin-Wilczyńska³

et al. 2018

Ann Agric Environ Med.

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Partyka M, Chałas R, Dunin-Wilczyńska I, Drohomyretska M, Klatka M. Influence of growth hormone therapy on selected dental and skeletal system parameters. Ann Agric Environ Med. 2018; 25(1): 60-65. doi: 10.5604/12321966.1233573 Abstract Introduction. Growth hormone deficiency (GHD) is one of the main indications for growth hormone therapy. One characteristic of this disease is bone age delay in relation to the chronological age. Pituitary dysfunction negatively affects the growth and development of the jaws and teeth of the child. The secretion of endocrine glands regulates growth, development, and gender differentiation. It also controls the growth of bones and teeth, regulates metabolism of calcium and phosphate, proteins, lipids and carbohydrates. The primary role in the endocrine system is played by the pituitary gland which is responsible for the production of somatotropin [1]. Dysfunction of the pituitary gland has a negative effect on the growth and development of long bones in the body, and may have an adverse effect on the development of maxilla, mandible and dentition of a child. There is some information in the literature that dental age is delayed in short stature children; the replacement of deciduous teeth by permanent teeth is also delayed, and newly erupted permanent teeth often require orthodontic treatment. Applying hormonal therapy positively affects the process of replacement of dentition [2,3,4,5,6]. Objectives. The aim of the study was to assess bone and dental age, as well as analyze the state of dentition in children diagnosed with GH deficiency treated with growth hormone, depending on the duration of treatment. Materials and method. The study material consisted of 110 children (27 males, 83 females), hospitalized for somatotropin hypopituitarism in the Department of Paediatric Endocrinology and Diabetology at the Medical University of Lublin, Poland. The mean birth age was 13 years (156 months) with a standard deviation of 2 years and 6 months (30 months). 47 children (43%) started treatment with the growth hormone (group starting treatment) and 63 children (57%) whose treatment was started 2-3 years previously (group in the course of treatment). The control group consisted of 41 generally healthy children (15males, 25 females) with ENT problems, such as hypoacusis and a condition after nasal injury, hospitalized in the Department of Paediatric Otolaryngology at the Medical University of Lublin, Poland. The mean age was 11 years and 5 months (137 months) with standard deviation of 2 years and 5 months (29 months).

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Section: Discussionsupporting

confidence: 71%

“…There is some information in the literature that dental age is delayed in short stature children; the replacement of deciduous teeth by permanent teeth is also delayed, and newly erupted permanent teeth often require orthodontic treatment. Applying hormonal therapy positively affects the process of replacement of dentition [2,3,4,5,6]. Objectives.…”

mentioning

confidence: 99%

Influence of growth hormone therapy on selected dental and skeletal system parameters

Partyka¹,

Chałas²,

Dunin-Wilczyńska³

et al. 2018

Ann Agric Environ Med.

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“…16,17 In Japan, GH therapy was approved only for managing GHD in specific child chronic diseases in 1975 and for managing Turner syndrome accompanied by GHD in 1990.…”

Section: Discussionmentioning

confidence: 99%

Effects of Growth Hormone on Craniofacial Growth

Funatsu

Sato

Mitani

2006

The Angle Orthodontist

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Objective: This study determined the effects of growth hormone (GH) therapy on craniofacial growth in idiopathic growth hormone deficiency (GHD). Materials and Methods: Fifty-seven patients (33 boys and 24 girls; age range 4.5 to 16.7 years) with GHD were investigated and categorized into three groups according to the duration of GH therapy: the untreated group, the short-term therapy group, and the long-term therapy group. Their lateral cephalometric radiographs were studied, and craniofacial measurements were assessed by age and sex by using matched standard deviation scores. Results: In the untreated group, the anterior cranial base, total facial height, maxillary length, mandibular total length, mandibular body length, and ramus height were smaller than the standard values. In comparison with the untreated group, the long-term therapy group had a significantly larger upper facial height (P Ͻ .05), maxillary length (P Ͻ .01), and ramus height (P Ͻ .01) measurements. Conclusions: Children who received long-term GH replacement therapy showed increased growth of the craniofacial skeleton, especially the maxilla and ramus. These findings suggest that GH accelerates craniofacial development, which improves occlusion and the facial profile.

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“…10 It is recognized that the mechanisms that regulate craniofacial growth and development include complex interactions between genes, hormones, nutrients, and epigenetic factors that produce the final craniofacial morphology, and any disturbances in this mechanism may result in a deviating growth pattern. 11,12 However, according to the literature, it is unknown whether prematurely born children are at risk of altered craniofa- cial morphology. 8 Therefore, the aim of this study was to evaluate the craniofacial morphology in extremely and very preterm born 8-to 10-year-old children and to compare these findings with those in matched fullterm born controls.…”

Section: Introductionmentioning

confidence: 99%

Craniofacial Morphology in Prematurely Born Children

Paulsson

Bondemark

2009

The Angle Orthodontist

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Objective: To test the null hypothesis that there is no difference between the craniofacial morphology of prematurely born children and that of matched full-term born controls. Materials and Methods: White children 8 to 10 years of age, born at the University Hospitals of Lund and Malmö and living in the same part of Sweden, were included. One group consisted of 36 very preterm children, born during gestational weeks 29 to 32; the other group included 36 extremely preterm children, who were born before the 29th gestational week. Subjects were compared with a control group of 31 full-term children, who were matched for gender, age, nationality, and living area. One lateral head radiograph was taken for each child, and the cephalometric analysis included 15 angular and 11 linear variables. Also, the height, weight, and head circumference of each child were registered. Results: A significantly shorter anterior cranial base and a less convex skeletal profile were found among extremely preterm children, and significantly shorter maxillary length was noted in both extremely preterm and very preterm groups as compared with full-term children. The lower incisors were significantly more retroclined and retruded in the extremely preterm group compared with the very preterm group and the full-term control group. Extremely preterm children were significantly shorter, and both extremely preterm and very preterm children had significantly lower weight and smaller head circumference compared with full-term children. Conclusion: The null hypothesis was rejected because several craniofacial parameters differed significantly between preterm and full-term born control children. (Angle Orthod. 2009;79: 276-283.)

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Craniofacial morphology, dental occlusion, tooth eruption, and dental maturity in boys of short stature with or without growth hormone deficiency

Cited by 74 publications

References 18 publications

Influence of growth hormone therapy on selected dental and skeletal system parameters

Influence of growth hormone therapy on selected dental and skeletal system parameters

Effects of Growth Hormone on Craniofacial Growth

Craniofacial Morphology in Prematurely Born Children

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